Exogenous IGF-1 promotes hair growth

[noisette]

May be beneficial for the restoration of human hair loss and which may be used as an alternative to synthetic drugs.

" Local injection of IGF-1 increased hair follicle number and prolonged the growing phase during the transition from anagen to telogen. Meanwhile, immunology analyses revealed that IGF-1 also stimulated the proliferation of follicle cells in anagen of the matrix and down regulated TGF-β1 expression in hair follicles. "

source :http://www.growthhormoneigfresearch....%2900023-9/pdf

And here an other abstract published on 4 december 2014 :

http://www.ncbi.nlm.nih.gov/pubmed/25484129

[tiktok]

As someone who bought igf-lr3 and tried to inject it into his scalp... it's not easy going. Gave up after a week.
Would love to find some sort of topical igf-1 though.

[Follicle Island]

Five years ?

[Shinobi]

This is in mice however it was already confirmed to be downregulated in dp cells balding scalp in human :

http://www.ncbi.nlm.nih.gov/pubmed/24499417

Baicalin in vitro upregulate it by a 4 folds level

[Seuxin]

Interresting....but....How doing with this now ?

[kobefan234]

so why not inject human growth hormone which causes IGF-1 release from the liver? So exogenous hGH can do the same thing. Exogenous IGF-1 ( Increlex ) is brutally expensive.

[noisette]

Interresting....but....How doing with this now ?

Perhaps with Follicept, my friend

[joachim]

thanks, good job noisette! you've found a lot of nice igf1 studies during these last weeks.
the only question now is if igf1 in humans is a strong factor as in mice. if so, then follicept could hold the key.

as you're good at searching studies, here's another thought: besides IGF1 there must be other growth factors which are beneficial for hair growth.
maybe you could look for similar studies as well, where other growth factors come into play. maybe we have the chance to use them with follicept too, if the dose is low enough to be treated as cosmetic.
just an idea.

[burtandernie]

Isnt this exactly what follicept was trying to do? So if it works they are going to find out.

[noisette]

VEGF a growth factor for Follicept perhaps...

thanks, good job noisette! you've found a lot of nice igf1 studies during these last weeks.
the only question now is if igf1 in humans is a strong factor as in mice. if so, then follicept could hold the key.

as you're good at searching studies, here's another thought: besides IGF1 there must be other growth factors which are beneficial for hair growth.
maybe you could look for similar studies as well, where other growth factors come into play. maybe we have the chance to use them with follicept too, if the dose is low enough to be treated as cosmetic.
just an idea.

Thank you brother

I can give you Three interesting studies :

1. One called: Paracrine crosstalk between human hair follicle dermal papilla cells and microvascular endothelial cells. and published on 2015 Feb 18

" Accordingly, Human follicle dermal papilla cells enhance the endothelial release of VEGF and IGF-1 "

source : http://www.ncbi.nlm.nih.gov/pubmed/25690790

2. Other one called: Hematological and hepatic effects of vascular epidermal growth factor (VEGF) used to stimulate hair growth in an animal model and pubished on 10/ 2013

" VEGF increased hair follicle area, but more studies are necessary to confirm its toxicity " " The aim of this study was the evaluation of a topical gel enriched with VEGF liposomes on the hair growth stimulation "

source: http://www.biomedcentral.com/1471-5945/13/15

3. The last one called : Expression and Purification of Functional Human Vascular Endothelial Growth Factor-A 121 ; the Most Important Angiogenesis Factor

" This process is an essential component in the growth of normal cells and tissues during embryonic development, reproductive cycle and wound healing "

source: http://journals.tbzmed.ac.ir/APB/Abs...20140122141755

[NOhairNOlife]

So does this validate follicept and what they're trying to do?!

I second that, noisette, you've done some great research. I'd love to do my own research but I don't have the understanding you do on this stuff. Glad somebody out there does. Keep it up man.

[noisette]

This is a study that I found on December 2014. This stuff seems to validate Follicept. Follicept have a transdermal technology which is more effective than injections, according to Dr Hsu and some experts on research gate website. So this is exciting for me. The only thing is... IGF1 dose. And why not, if they can add VEGF.... who knows ?

[noisette]

Many thanks man... I really appreciate it...

[hellouser]

This is a study that I found on December 2014. This stuff seems to validate Follicept. Follicept have a transdermal technology which is more effective than injections, according to Dr Hsu and some experts on research gate website. So this is exciting for me. The only thing is... IGF1 dose. And why not, if they can add VEGF.... who knows ?

Doesn't mean a thing until RESULTS are made public.

[youngin]

People really need to stop misrepresenting these studies. No one is looking at the big picture. STOP MISLEADING PEOPLES HOPES. Dermal papilla's PRODUCE growth factors. READ THAT AGAIN. One factor they produce is IGF1. The smaller the DP the less IGF1 they produce. You are simply supplementing one factor to the follicle that's been miniaturized. This is not a smoking gun. Supplementing one growth factor and not the others is probably not a win. LOOK AT HISTOGEN which supplemented all growth factors and did not have great results.