Why Azelaic Acid should work in theory

[AnteUp]

DHT causes an increase in p53 and p21 expression, which leads to DKK1 apoptosis of the hair follicle. Azelaic acid represses p53 and p21.

http://www.ncbi.nlm.nih.gov/pubmed/22859066
http://www.ncbi.nlm.nih.gov/pubmed/23278893

Also, apparently Azelaic acid competes with the NADPH sites of 5 alpha reductase. No clear proof, but sure explains why some articles and people on the forums with acedotal evidence claim that Azelaic acid works as a 5 alpha reductase inhibitor.

[AnteUp]

This is how azelaic acid may hinder hair growth.

http://www.ncbi.nlm.nih.gov/pubmed/11012661
http://www.ncbi.nlm.nih.gov/pubmed/11012661
http://www.nature.com/jid/journal/v1...id201482a.html

Azelaic acid inhibits thioredoxin reductase. Thioredoxin reductase is required for NF-kappaB DNA binding. NF-kappaB is needed for the anagen cycle in human hair follicles.

Any thoughts?

[Jazz1]

I use this combination past 2 years and this formula works wonders for me:

15% minoxidil
1.5% azelaic acid
0.1% finesteride
0.25% progesterone
0.025% tretinoin.

[Paul73]

I use this combination past 2 years and this formula works wonders for me:

15% minoxidil
1.5% azelaic acid
0.1% finesteride
0.25% progesterone
0.025% tretinoin.

Good to know, Jazz. Could you please tell where do you order this topical?

Also, are you using oral finasteride?

Thanks!

[Jazz1]

See here or check my threads:

https://www.baldtruthtalk.com/showth...240&highlight=

The products by compounding pharmacist:

https://www.baldtruthtalk.com/showth...446&highlight=

My regrowth thread:

https://www.baldtruthtalk.com/showth...582&highlight=

[Jorans42]

tretinoin for hair loss? thats news to me

[Paul73]

See here or check my threads:

https://www.baldtruthtalk.com/showth...240&highlight=

The products by compounding pharmacist:

https://www.baldtruthtalk.com/showth...446&highlight=

My regrowth thread:

https://www.baldtruthtalk.com/showth...582&highlight=

Thanks for the links, Jazz!

Could Azelaic Acid inhibit hair regrowth in your opinion? I got a little worried after reading those studies posted by AnteUp.