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World's 1st iPS cell transplant performed in Japan
KOBE (Jiji Press) — A team led by RIKEN researcher Masayo Takahashi performed a transplant of retina cells on Friday on a woman suffering from an eye disease, in the world’s first clinical study using induced pluripotent stem, or iPS, cells.
The surgery was carried out on a female resident of Hyogo Prefecture in her 70s at the Institute of Biomedical Research and Innovation Hospital in Kobe in the western Japan prefecture.
The surgeons included Yasuo Kurimoto, a doctor at the hospital.
In the study, the team led by Takahashi, a member of the RIKEN Center for Developmental Biology, also in Kobe, will confirm the safety of retina cells produced from iPS cells, which are capable of developing into almost all types of tissue.
The team will spend four years to check whether the transplanted cells take hold, whether the cells turn cancerous, and whether the treatment improves the eyesight of the subject.
The transplant was conducted to treat exudative age-related macular degeneration, which causes abnormal blood vessel formation in the retinas and could lead to total loss of vision.
The subject was chosen because she was suffering from a disease type that is hard to treat with existing drugs or treatment.
In the surgery, a damaged portion of pigment epitheliums, a type of tissue that conveys nutrition to sensory retinas, was replaced with new pigment epithelium cells produced from iPS cells that were created from skin cells of the subject.
Takahashi filed for the clinical study with a panel of the health ministry in February last year and approval was granted in July that year. The panel conducted an additional examination to see whether the transplanted cells would turn into cancer cells. On Monday, it concluded that the transplant is unlikely to cause any serious problem.
The clinical study enjoys strong support from Kyoto University Prof. Shinya Yamanaka, the inventor of iPS cells who won a Nobel prize in 2012. The Kyoto University Center for iPS Cell Research and Application supplied plasmid, a circular DNA molecule needed to produce iPS cells, to the Takahashi-led team.
The study was overshadowed by research fraud over stimulus-triggered acquisition of pluripotency, or STAP, cells by Haruko Obokata, member of the RIKEN center. Takahashi criticized RIKEN’s handling of the incident and in July this year said in a Twitter message that she may have to consider halting her iPS study.
http://the-japan-news.com/news/article/0001564776
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Senior Member
Nice find ! They started with this trial some months ago, great to hear they've now treated a patient. Great week for the iPS front !
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So when is USA going to step up it's game with stem cell USAGE as regenerative medicine? All this work on mice and rats doesn't help humans. Sigh.
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I wonder that if those christians (no offense) didn't interfere with stem cell research if we had the cure by now.
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Originally Posted by 2young2bald
I wonder that if those christians (no offense) didn't interfere with stem cell research if we had the cure by now.
LOL, religion in general has been interfering with humanity's advancement for millenniums.
Thanks to fictional characters of all sorts all around the world which have been used as an excuse to eradicate people rather than improve the quality of life, we're now centuries behind as an evolved species.
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Originally Posted by hellouser
LOL, religion in general has been interfering with humanity's advancement for millenniums.
Thanks to fictional characters of all sorts all around the world which have been used as an excuse to eradicate people rather than improve the quality of life, we're now centuries behind as an evolved species.
Totally Agree...
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so it's going to be a 4 year trial? Well, it'll probably come sooner than replicel or histogen or whatever crap is still yet to come..
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Originally Posted by hellouser
All this work on mice and rats doesn't help humans. Sigh.
Simply not true. The list of advancements first made using laboratory animals is endless.
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Originally Posted by walrus
Simply not true. The list of advancements first made using laboratory animals is endless.
Sure, but how about APPLYING the findings to humans?
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Originally Posted by hellouser
Sure, but how about APPLYING the findings to humans?
One there is sound understanding of the mechanisms, efficacy, and safety can be assured---that is exactly what happens.
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