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  1. #1
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    Default A traditional hair loss lotion from SouthEast Asia contains natural JAK inhibitor

    I want to share this finding. Although I don't think that the concentrations found in the herb itself or lotion (usually concentrations are too low) would produce cosmetically acceptable regrowth in most cases, it indicates that the lead of JAK inhibitors may be the key to pharmacological hair treatment.

    this traditional herbal shampoo used in Southeast Asia seems to confirm the usefulness of JAK inhibitors for MPB hair loss.

    There are several brands in Thailand, Philippines, India, e.g.:
    Jinda Hair Lotion with Litsea glutinosa extract:
    http://www.greenherbmarket.com/en/191--100-.html


    Litsea glutinosa ("shampoo tree" in Thailand, or Indian Laurel) contains Brevilin A. Researchers have recently found that this compound is a significant JAK inhibitor:

    http://www.plosone.org/article/info%...l.pone.0063697

    The roles of Brevilin A targeting on JAKs activity indicate that Brevilin A may not only be used as a STAT3 inhibitor but also a compound blocking other JAK-STAT hyperactivation...

    Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals...

  2. #2
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    Good find, bro. At this moment, I wonder if the users of the lotion have had any success. It's really tiring to keep taking punches in the dark with a new additive each time.

  3. #3
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    Quote Originally Posted by inbrugge View Post
    Good find, bro. At this moment, I wonder if the users of the lotion have had any success. It's really tiring to keep taking punches in the dark with a new additive each time.
    There are some amazing picture on the net, but probably photoshop or longer hair...http://www.ebay.com/itm/Jinda-Herb-H...-/271312421862

    What I find interesting is how science may end up confirming some herbal remedies that have been used for millennia. Centipeda, an Australian plant used by the aboriginals for hair growth also contains Brevilin A!
    http://www.hylunia.com/ingredient-di...amii-extract-2

    Brevilin A is sold pure from chemical companies, but I guess there would be unknown safety problems, like with the synthetic JAK inhibitors.

  4. #4
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    This should also be sent to christiano. Those photos look like they are the same person. I have great faith in traditional medicines, not to provide full cures, but to point the way towards what works and what doesn't. this was a great find.

  5. #5
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    Quote Originally Posted by sdsurfin View Post
    This should also be sent to christiano. Those photos look like they are the same person. I have great faith in traditional medicines, not to provide full cures, but to point the way towards what works and what doesn't. this was a great find.
    The Chinese have patented Brevilin A in its use as a JAK inhibitor. However, I understand that natural products cannot be patented in the US and EU.

    http://www.google.com/patents/CN102836151B?cl=en
    Last edited by Recidive; 09-10-2014 at 06:34 PM. Reason: Better link

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    I read somewhere that janus kinase inhibitors promote CD200 progenitor cells (tofacitinib should do this). Downregulation of CD200 cells is present in AGA, I believe Cotsarelis talked about it at one point.

    This Brevilin A could be interesting....

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    Quote Originally Posted by hellouser View Post
    I read somewhere that janus kinase inhibitors promote CD200 progenitor cells (tofacitinib should do this). Downregulation of CD200 cells is present in AGA, I believe Cotsarelis talked about it at one point.

    This Brevilin A could be interesting....
    These manufacturers sell pure Brevilin A if you are interested...
    http://www.chemicalbook.com/ProdSupp...2519594_EN.htm

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    Spam

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    Quote Originally Posted by blondetooth View Post
    Spam
    Why spam ? argues bro

  10. #10
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    Quote Originally Posted by Recidive View Post


    Litsea glutinosa ("shampoo tree" in Thailand, or Indian Laurel) contains Brevilin A. Researchers have recently found that this compound is a significant JAK inhibitor:

    http://www.plosone.org/article/info%...l.pone.0063697

    The roles of Brevilin A targeting on JAKs activity indicate that Brevilin A may not only be used as a STAT3 inhibitor but also a compound blocking other JAK-STAT hyperactivation...

    Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals...
    ... in cancer cells...

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