ruxolitinib and/or tofacitinib?

[johnsmith]

Does anyone have any comments or thoughts regarding ruxolitinib and/or tofacitinib as a potential medicinal treatment for male pattern hair loss?

There was an announcement today about both drugs [1]. Please discuss.

1. http://time.com/3136230/alopecia-dru...0Top%20Stories)

[joachim]

Does anyone have any comments or thoughts regarding ruxolitinib and/or tofacitinib as a potential medicinal treatment for male pattern hair loss?

There was an announcement today about both drugs [1]. Please discuss.

1. http://time.com/3136230/alopecia-dru...0Top%20Stories)

it's being discussed on other forums, too.

i think it will not help for MPB because the cause of hairloss is simply totally different in AA. (although nobody knows exactly).
but i'm also curios if it could have some minor positive effect for MPB too.
the drug is also FDA approved already, so the question is, how to get the drug and what side effects it can cause. if a use of 5 months or so doesn't cause serious side effects then i'm sure some of us would be willing to try it. but there's no doctor which would prescribe it off-label, i guess.

however, for AA sufferers this could be indeed a breakthrough. i'm feeling happy for those people.

[hgs1989]

I think alopecia areata is officially cured now. it would be a disappointment if someone with alopecia areata is treated to find that he MPB.

[hellouser]

I think alopecia areata is officially cured now. it would be a disappointment if someone with alopecia areata is treated to find that he MPB.

How about a cure for the people that make up 99% of the ****ing bald community?

[hgs1989]

How about a cure for the people that make up 99% of the ****ing bald community?

molecular biology holds the answer to this. I don't wanna deviate from the subject,but I am tempted. we know almost every piece of the puzzle on a molecular level of how dht makes your hair fall.it is a matter of when will biologists be comfortable with these chemicals. and for completely bald people, I also believe that all they need is a signal to tell their stem cells to start making follicles.

[hgs1989]

angela christiano patented this stuff for hair loss. androgentic alopecia is included in the patent. I wonder if this inclusion just to cover a possibility of effectiveness or she actually thinks it works for MPB, given that inflamation is somehow involved in MPB.

http://www.google.com/patents/WO2013149194A1?cl=en

[bigentries]

angela christiano patented this stuff for hair loss. androgentic alopecia is included in the patent. I wonder if this inclusion just to cover a possibility of effectiveness or she actually thinks it works for MPB, given that inflamation is somehow involved in MPB.
http://www.google.com/patents/WO2013149194A1?cl=en

That's promising, but in one interview, she admits AGA is a different beast and her approach will most likely not work at all

Her story is really interesting, she has AA and the diagnosis made her become involved in the field. She found the genetic basis of AA and deduced that it was linked to some diseases like psoriasis in less than two years people started trialling these kind of drugs that are very effective at treating psoriasis, and we already some cases of complete reversal of the condition

[Jonathan]

How about a cure for the people that make up 99% of the ****ing bald community?

Its amazing how you can turn good news to something negative. Let us at least be happy for all that suffers from AA.

(The SNL clip is very funny, but as the designer you are, do you really think it works good as an Avatar? I find it extremaly annoying

[hellouser]

Its amazing how you can turn good news to something negative. Let us at least be happy for all that suffers from AA.

(The SNL clip is very funny, but as the designer you are, do you really think it works good as an Avatar? I find it extremaly annoying

It's shitty news for us because while a small minority get a (much needed) break, the rest of us, in vastly larger numbers, STILL get overlooked. What life has taught me is that no matter how much great shit happens for others, people in general still don't give a damn about you (or me). So while I recognize their needs for treatment, it still doesn't help the fact that researchers, doctors and society as a whole have done shit all for us except for demonizing our condition to the point where it's become socially ACCEPTED to mock us for it.

So... am I happy? No, I'm still screwed. You won't see a smile on my face when I see this effing curse be wiped off the planet for myself and all other bald men that deserve MUCH BETTER.

[Jonathan]

I am also frustrated and would do almost anything for a cure. But I am also certain that the researchers and investors out there don't overlook the billions of value there is in finding a cure, even if they don't care about you and I as persons.

I cant see how a cure for AA could make my life worse or how it could slow down the MBP research. Therefor I am happy for those suffering from AA if it now shows there is a cure.

[CAlex]

WOW the bubble some people live in. A real cure which will change these guys lives doesnt make you happy because the cause is different than ours. How F'dup are you.

Seem like one of those twisted people that if they could cure themselves today but would be condemning the rest of us would do it. I saw the thread earlier on this and am ridiculously happy for all these guys.
Anyone on here who isnt happy for these guys NEVER deserve to be cured. This treatment wont likely yield any treatment for us but who cares. seems like a lot of guys have lost a lot more than their hair.

All this guy ever does is whine. No one cares about us..No one cures us. What have you done to cure yourself?

you should have gone into the field, or become wealthy and fund research. No breakthrough or article is ever good enough for you. Pretty sure I could list 50 worst situations to have/be experiencing than hairloss off the top of me head.

[hellouser]

WOW the bubble some people live in. A real cure which will change these guys lives doesnt make you happy because the cause is different than ours. How F'dup are you.

Seem like one of those twisted people that if they could cure themselves today but would be condemning the rest of us would do it. I saw the thread earlier on this and am ridiculously happy for all these guys.
Anyone on here who isnt happy for these guys NEVER deserve to be cured. This treatment wont likely yield any treatment for us but who cares. seems like a lot of guys have lost a lot more than their hair.

All this guy ever does is whine. No one cares about us..No one cures us. What have you done to cure yourself?

you should have gone into the field, or become wealthy and fund research. No breakthrough or article is ever good enough for you. Pretty sure I could list 50 worst situations to have/be experiencing than hairloss off the top of me head.

Wow, the lack of relativity some people have.

[Auld Reekie]

It's shitty news for us because while a small minority get a (much needed) break, the rest of us, in vastly larger numbers, STILL get overlooked. What life has taught me is that no matter how much great shit happens for others, people in general still don't give a damn about you (or me). So while I recognize their needs for treatment, it still doesn't help the fact that researchers, doctors and society as a whole have done shit all for us except for demonizing our condition to the point where it's become socially ACCEPTED to mock us for it.

So... am I happy? No, I'm still screwed. You won't see a smile on my face when I see this effing curse be wiped off the planet for myself and all other bald men that deserve MUCH BETTER.

In the UK we have this tabloid newspaper called 'The Sun'. They like to put certain words in capital letters, too, to help the reader know what they're supposed to think, it's basically a comic book for grown ups and free-thinking people with ONE brain cell tend to avoid it. It would be nice if you could do us the courtesy of letting us form our own opinions without being spoon fed in capital letters, it's pretty demeaning.

[NeedHairASAP]

I thought after the PGD2 connection we realized that AA and MPB were actually more similar than previously thought?

They are obviously both inflammation/immune system issues. While not the same, I'm pretty sure they are not vastly different to the point we should ignore AA solutions completely.