Japan stem cell laws (fast track)

[Slam1523]

Thanks doc... So what would your prescription for this fine gentlemen be? First off go pound sand and quit telling people what they're allowed to let bother them... How can you tell someone they are pathetic for letting hairloss impact them as much as they say it does, but somehow think nothing is wrong with the fact that you let the fury of the four horseman come out in your comments because a frustrated person made a comment? We get it, it's tough, but we can't let hair loss ruin our lives like you apparebtly let community forum posts do... Now get a grip, and focus on the freaking thread title or scram!

[nameless]

+1

Not to mention researchers are not purposely trying to stall anything, everyone wants to do things as quickly as possible, but you have to do things properly and according to how much money there is available. Hellouser needs a shrink really desperately, there are other issues besides hairloss going on there, trust. He's already managed to insult dr. wesley and dr. gardner with his BS rants about researchers being "unnaceptable" in their progress etc etc. I'm not here to insult anybody but yeah, coping and acceptance of loss in general is part of life- there are much worse kinds of loss that will affect all of us, and that kind of attitude that life can't be good without hair is self-defeating, immature, and not indicative of a mature and healthy psychology. The younger forum posters should realize that, and also realize that there are more people working fast on hairloss than on many much worse and much more life damaging diseases.

Wow! You're so cool about hair loss. At least your words in this one post about hair loss are cool. But in reality you hang out at, at least one hair loss website, and perhaps others. You know a lot about hair loss so you have researched it quite a bit. You are way more heavily involved in hair loss than the people who have come to cool terms with hair loss. You're obviously obsessed with your hair loss despite your efforts to paint yourself otherwise. So basically your negative post about Hellouser in this instance is a matter of the pot calling the kettle black.

Sdsurfin, let me try to explain something to you. A person who is a tiny bit disfigured crying about it all the time is over-reacting and too whiny. But a person with a major disfigurement who is upset about it and complaining about it is merely reasonable. I was reading a story the other day about some young men who have too much hair. They have what some people call "Werewolf Syndrome." It's sad. They have hair everywhere. It's just hair but they live part time in circuses, and have for a lot of their lives. That's where they earn a living. That's their lives. And if you think that when they're away from the circuses they have normal social interactions and desirable women then you should re-think that idea. And of course their condition is worse than baldness but for the record the bald man also used to be in circuses. And the only reason the condition called "Werewolf Syndrome" is worse than baldness is because it's rare so people are shocked when they see it. But all you have to do is look at the before-and-after pics of bald men who have recovered their hair and you will learn that baldness also causes a major negative change in how a person looks. The difference in the way a man looks when he has his hair vs how he looks if he loses his hair is not a minor or mild difference. The difference is drastic. It's huge. It's like night and day. You can not tell they are the same person. And when a man loses his hair the difference in how he looks is almost always for the negative. Do you know what the definition of a disfigurement is? Here it is:

"the action of spoiling the appearance of something or someone"

Plain and simple, baldness is a disfigurement. And it's not a minor disfigurement. It's a huge disfigurement. I'm not one bit ashamed that I can't adjust to it. If I was one of those young men with what's called "Werewolf Syndrome" I would be unable to adjust to that either. And if it was you then instead of you hanging out at hair growth websites looking for a cure you would be hanging out at hair reduction sites looking for a cure.

Be real.

[JZA70]

Most men lose their hair, it's normal.

I agree with most of what you said except for this part. It's not normal to be a balding twenty something year old. According to statistics, only 2/10 (20%) men have some degree of hair loss during their twenties. That means 8 out of your 10 friends have perfect hair.

Then you go into your thirties and see that only 3/10 (30%) men have some degree of hair loss. That means that 7 out of your 10 friends have perfect hair through their thirties. It's difficult to feel normal when you look at these statistics. Like I said, I do agree with most of what you said, except for the fact that it's "normal" to lose hair. If you're in your 50's, sure, but when your 20 and balding, you're the odd man out, and no one wants to be the oddball. It's even worse when you're a balding teenager.

[JJJJrS]

Because you have ONE life. And the life many of us have been given has been total shit. Perhaps it would help not to be so ignorant of the suffering of others and wish for a quick solution for them rather than sit around and be complacent?

If I knew there was something I could do to get a cure out in the near future, trust me, I'd be all over it. But first there actually needs to be an effective treatment developed and that's completely out of our hands, unless you happen to be a scientist researching this subject. There is absolutely no evidence that Replicel is at all effective so harassing the company for an early release is ridiculous. It has nothing to do with complacency. The same goes for opening a clinic in the Bahamas run by Dr. Nigam (thanks jarjar, I really needed a laugh ) to offer another questionable treatment.

MPB is an extraordinarily difficult problem to solve. It's something we're genetically programmed to have and you can't just snap your fingers and expect a cure. Nobody owes you a cure. There are so many more diseases and conditions which are far more crippling than baldness and rightly deserve more attention. Like I said earlier though, if it's something you feel really strongly about, then try to solve the problem yourself instead of complaining on forums and demanding others to fix it for you.

[sdsurfin]

I agree with most of what you said except for this part. It's not normal to be a balding twenty something year old. According to statistics, only 2/10 (20%) men have some degree of hair loss during their twenties. That means 8 out of your 10 friends have perfect hair.

Then you go into your thirties and see that only 3/10 (30%) men have some degree of hair loss. That means that 7 out of your 10 friends have perfect hair through their thirties. It's difficult to feel normal when you look at these statistics. Like I said, I do agree with most of what you said, except for the fact that it's "normal" to lose hair. If you're in your 50's, sure, but when your 20 and balding, you're the odd man out, and no one wants to be the oddball. It's even worse when you're a balding teenager.

Hate to tell ya, but 2/10 people is still pretty normal. More common than being a redhead or being gay, and both of those things are pretty normal. I have friends who lost their hair in their 20s and no one ever considered them abnormal. I am genuinely sorry for anyone who can't cope with hair loss, all I am saying is that in that case, it's more a question of getting your brain right than your hair. Everybody loses something in life, no one is spared life's fury. What makes you a man/woman and a mature person is how you deal with that loss. Sure, hair looks better than no hair, but looks really don't mean very much especially as you age, and MANY people actually find baldness attractive. I'd say at least half of my female friends are into bald guys, and the other half don't really care if the guy is attractive in other ways. I mean hell, some of my friends get discriminated against by women off the bat more often for being jewish or black or not jewish or short or not rich enough. I can't even count the times I've been at a party or bar and seen the hottest girl there with a bald guy. If you don't care about women and the only thing that bothers you is how you look to yourself, then you need to learn to place your self esteem on something other than your looks and your hair. Also, I'm pretty sure your stats are off, something like 60% of guys have lost some hair by 35, and if you're just counting caucasian dudes then it's probably more.

If you're in your twenties, then I really wouldn't worry too much. By the time you're 35, which is still really young, there will probably be an all out cure.

In response to nameless- yeah I think about hair loss a bit more often than I should, but I don't go on forums and rant against researchers or say that my life is total shit (which it isn't) or make other people feel like this is all a way bigger deal than it actually is. I go on here because I can still do something about my hair, and I like to see what's happening with drugs, especially since I've been on the fence about using finasteride and rogaine etc, and I find the stem cell science to be really intriguing. As far as disfigurement goes, sorry I can't agree. I know bald guys who look great, they just look different than they used to. sure, when dudes let the sides keep growing clown style it looks pretty bad, but otherwise handsome is handsome and ugly is ugly, and either way it doesn't define who you are as a person. Whether you bald in your teens or when youre 50, it happens to almost everyone, and people are used to it. In most cultures shaved heads are very ordinary. Pick any crowd and spit and your chances of hitting a bald/ing guy are pretty damn high. Disfigurement or growing hair like a werewolf is not something you see all around, and is something that makes you look not just different, but truly damaged. Either way, it doesn't matter what your definition is, or how much it means to you- what's important is how you deal with it, because you only have one life. I know people who are truly disfigured- like it's hard to look at them, or crippled or in wheelchairs and they dont complain that society isnt doing things fast enough for them or that their lives are shit. My most handsome friend just learned that his mom has alzheimers, so he might look like a model, but one day he might not even know who the hell he is. everyone suffers, your only choice is how to be as happy as possible and be uselful to others and to yourself.

[Jasari]

If you're in your twenties, then I really wouldn't worry too much. By the time you're 35, which is still really young, there will probably be an all out cure.

This is the crux of the dilemma that will make any argument towards maturity [Re:Overcoming Hair loss] null and void. Hair loss in your twenties [I.E Norwood 3 or greater] is the end of your 20s. Irrespective of what a birth certificate may say; the loss of your hair at such a young age [Unfortunately] wipes 10 years of your life that will never come back, especially in a world predicated on timelines & deadlines.

Of course you're correct in saying that it's relatively common & nowhere near the worst affliction to have. The big 'BUT' however is that mental aspect of the issue runs far deeper than the physical. As an example: Consider the fact that hair loss is one of the primary triggers for a mid 40s male entering a mid life crisis. It has for a long time been seen a contributing factor for the consideration of ones own mortality. To have this at the start of your adult life will no doubt cause psychological issues which are far tougher to overcome than a simple 'Chin up, move on' mentality.

[James7]

Topic resumed: Japan stem cell laws

Hellouser, please read:

It's been discussed before and I've mentioned it before in other Replicel threads that they would NOT necessarily need Phase II completion in order to roll out a treatment. Japan's regulations (or now deregulation) allows stem cell therapies to make it for consumer use DURING phase II trials but conditionally.

Hi, do you have a source that explicitly states, that they can get conditional approval during phase 2?
A link would be good thanks

All the links I have read state that they definately don't need a phase 3.
Even being able to skip phase 3 alone, would be a game changer.
So I'm interested to find out more about the new stem cell laws in general, and the possibilty of conditional approval during phase 2.

Back on topic though... seeing how Shiseido is funding Replicel and is based out of Japan, and *might* have their own labs, we really should badger the shit out of Replicel asking them (forcing) to take advantage of the new regulations. They're starting Phase II this year, and David Hall mentioned results in 2016 in a recent interview (press releases indicated 2017 via a 39 month Phase II trial). Imagine, if halfway through that they could give us treatment? Essentially, in less than 2 years?

And yet.... everyone prefers to be a naysayer?

please see the link below:

http://www.replicel.com/replicel-life-sciences-licensing-partner-shiseido-opens-cell-processing-and-expansion-facility-in-japan-to-advance-rch-01-a-treatment-for-pattern-baldness/

Shiseido opened their lab on May 18th 2014

Also, I understand you're keen to see them move forward quickly, like we all are, and you are probably just venting your concern (when you mention badgering or something lol). You really don't have to worry about that. They already have all the incentive they need.

Remember, they already have a huge incentive to move forward:
Shiseido will pay them $30M in milestone payments.

[sdsurfin]

This is the crux of the dilemma that will make any argument towards maturity [Re:Overcoming Hair loss] null and void. Hair loss in your twenties [I.E Norwood 3 or greater] is the end of your 20s. Irrespective of what a birth certificate may say; the loss of your hair at such a young age [Unfortunately] wipes 10 years of your life that will never come back, especially in a world predicated on timelines & deadlines.

Of course you're correct in saying that it's relatively common & nowhere near the worst affliction to have. The big 'BUT' however is that mental aspect of the issue runs far deeper than the physical. As an example: Consider the fact that hair loss is one of the primary triggers for a mid 40s male entering a mid life crisis. It has for a long time been seen a contributing factor for the consideration of ones own mortality. To have this at the start of your adult life will no doubt cause psychological issues which are far tougher to overcome than a simple 'Chin up, move on' mentality.

First off- you don't lose ten years of life if you go bald. I have friends who went bald in their early twenties and still had a great time. that is not a lie or a sugarcoating. People who can accept and embrace loss don't let it ruin their lives. I am not saying it isn't a tough card to get. My point is very well highlighted by what you said, it's a tough psychological experience that affects many men, and people who can't handle it need psychological help, not more hair. It very may well need more than just a chin up mentality, and if it does, then you need to seek help. Sure , you might be happy with hair, but if your psychology is such that you let something like this take away ten years of your life then even with hair you would be truly f-ed down the road when something really bad happens to you, which it does to most. My friend died when she was 21. that is losing your twenties. don't whine to me about losing ten years because your hair is leaving, if you are alive and thriving and not in poverty or in an abusive situation then you are luckier than a great percentage of the population. you haven't really lost anything except something nice but not totally necessary (if at all) for existence. Patrick stewart lost his hair at 15 and it didn't phase him, he dealt with the initial shock, had a productive and happy 20s and beyond. I know a lot of people like that, most of whom are not movie stars. You gotta just be happy no matter what, because everyone gets dealt bad cards at some point- you cant let physical or outside circumstances predicate your happiness, it's a decision that you make.

[Jasari]

First off- you don't lose ten years of life if you go bald. I have friends who went bald in their early twenties and still had a great time. that is not a lie or a sugarcoating. People who can accept and embrace loss don't let it ruin their lives. I am not saying it isn't a tough card to get. My point is very well highlighted by what you said, it's a tough psychological experience that affects many men, and people who can't handle it need psychological help, not more hair. It very may well need more than just a chin up mentality, and if it does, then you need to seek help. Sure , you might be happy with hair, but if your psychology is such that you let something like this take away ten years of your life then even with hair you would be truly f-ed down the road when something really bad happens to you, which it does to most. My friend died when she was 21. that is losing your twenties. don't whine to me about losing ten years because your hair is leaving, if you are alive and thriving and not in poverty or in an abusive situation then you are luckier than a great percentage of the population. you haven't really lost anything except something nice but not totally necessary (if at all) for existence. Patrick stewart lost his hair at 15 and it didn't phase him, he dealt with the initial shock, had a productive and happy 20s and beyond. I know a lot of people like that, most of whom are not movie stars. You gotta just be happy no matter what, because everyone gets dealt bad cards at some point- you cant let physical or outside circumstances predicate your happiness, it's a decision that you make.

It's not taking 10 years away in the sense that you have perceived my comments. I.E: You don't live life for those 10 years. Of course you do.

Where you lose the 10 years is through image. The 20 year old male with a Norwood 4 whilst being 20 on his drivers license is [For all intents & purposes] no longer 20. In a crowd of similar aged 'young adults' that tag of 'young' has disappeared.

For myself personally I've learn that there isn't any value to 'grading' how bad one might have it. At the age of 19 I developed a serious skin cancer on my leg which had spread to lymph nodes. It was one of the toughest pills to swallow for the next 12 months. I was however; very fortunate. At 21 my hair loss reached the stage of a Norwood 4a. This hit me just as hard as the cancer. It re-creates that very same sense of mortality awareness - You're no longer young. This is especially hard when you haven't had you're chance to be young. Whilst it's easy to say xyz has it worse than you - Human nature doesn't work that way. People adapt & the psychological trauma one will have with a large visible deformity will be similar to the trauma hair loss will bring.

Now for myself personally; I was able to get on with things & haven't missed out on anything as a result of hair loss. Of course I'm just as obsessed as you re: visiting this site, but relatively content none the less. This doesn't mean however that other people can move on.

[sdsurfin]

It's not taking 10 years away in the sense that you have perceived my comments. I.E: You don't live life for those 10 years. Of course you do.

Where you lose the 10 years is through image. The 20 year old male with a Norwood 4 whilst being 20 on his drivers license is [For all intents & purposes] no longer 20. In a crowd of similar aged 'young adults' that tag of 'young' has disappeared.

For myself personally I've learn that there isn't any value to 'grading' how bad one might have it. At the age of 19 I developed a serious skin cancer on my leg which had spread to lymph nodes. It was one of the toughest pills to swallow for the next 12 months. I was however; very fortunate. At 21 my hair loss reached the stage of a Norwood 4a. This hit me just as hard as the cancer. It re-creates that very same sense of mortality awareness - You're no longer young. This is especially hard when you haven't had you're chance to be young. Whilst it's easy to say xyz has it worse than you - Human nature doesn't work that way. People adapt & the psychological trauma one will have with a large visible deformity will be similar to the trauma hair loss will bring.

Now for myself personally; I was able to get on with things & haven't missed out on anything as a result of hair loss. Of course I'm just as obsessed as you re: visiting this site, but relatively content none the less. This doesn't mean however that other people can move on.

well that's good to hear. there are many reasons for people maturing and realizing their mortality. It happens to all of us regardless of hair loss. Young innocence doesn't last, so maybe be grateful that you mature early and learn what's truly important. up until a century ago 20 was not particularly young. my grandparents got married at 20 and had 5 kids by the time they were 26 or so. which was pretty standard. life is a bitch anyway you slice it and no one escapes, just gotta deal with the bad with a good attitude, especially when it comes to image stuff. girls are taught to be self conscious about pretty much every part of their bodies from a young age, which is why a lot of my girl friends have told me that they like bald guys, cause they are attracted to maturity and confidence in imperfection. pretty boys are a liability, and often wrapped up in vanity, which no real or interesting woman is into. cancer is a much bigger deal, that shit will kill you, and im glad you recovered.

[hellouser]

Topic resumed: Japan stem cell laws

Hellouser, please read:



Hi, do you have a source that explicitly states, that they can get conditional approval during phase 2?
A link would be good thanks

All the links I have read state that they definately don't need a phase 3.
Even being able to skip phase 3 alone, would be a game changer.
So I'm interested to find out more about the new stem cell laws in general, and the possibilty of conditional approval during phase 2.




please see the link below:

http://www.replicel.com/replicel-life-sciences-licensing-partner-shiseido-opens-cell-processing-and-expansion-facility-in-japan-to-advance-rch-01-a-treatment-for-pattern-baldness/

Shiseido opened their lab on May 18th 2014

Also, I understand you're keen to see them move forward quickly, like we all are, and you are probably just venting your concern (when you mention badgering or something lol). You really don't have to worry about that. They already have all the incentive they need.

Remember, they already have a huge incentive to move forward:
Shiseido will pay them $30M in milestone payments.

All the information I've posted can be found in BTT's Replicel forum:

https://www.baldtruthtalk.com/forums/42-Replicel

In regards to the fast tracked approval, it's in this thread:

https://www.baldtruthtalk.com/threads/15036-RepliCel-Reports-Progress-on-Shiseido-Technology/page9

Specifically, Replicel mentioned the fast tracked approval in a press release on May 20th, 2014:

http://www.replicel.com/replicel-life-sciences-licensing-partner-shiseido-opens-cell-processing-and-expansion-facility-in-japan-to-advance-rch-01-a-treatment-for-pattern-baldness/

Desmond I believe mentioned the new Japanese legislation a number of times, I think he's mostly been looking out for the potential of Tsuji Labs with the new de-regulation, which is good but it also affects Replicel and Shiseido's work in Japan as well.

All in all, this is very positive news for us... the only thing that remains to be seen is how well Replicel's treatment will work and if they're culturing in 3D versus the old 2D methods. David Hall made a recent interview stating results from Phase II trials will be made available in 2016. Check out the video below.

https://www.youtube.com/watch?v=zeW652S_zT8

He mentions this at the 2:45 minute mark.

[sascha]

Does anyone of you know of a treatment or drug, that already was released since the new legislation being active in Japan?

I hope they release it soon, we need some fresh air.
I ain't gonna try it myself, but god knows some of us need it, even if it's just 15% regrowth.
Shiseido will make a fortune regardingless of it's initial efficiency.

[hellouser]

Does anyone of you know of a treatment or drug, that already was released since the new legislation being active in Japan?

I hope they release it soon, we need some fresh air.
I ain't gonna try it myself, but god knows some of us need it, even if it's just 15% regrowth.
Shiseido will make a fortune regardingless of it's initial efficiency.

If it permanently halts hair loss, that in itself will be a gigantic leap forward as it would allow guys like myself to go in for a hair transplant and never worry about further loss or deal with effing finasteride/minox or other crap.

[sascha]

If it permanently halts hair loss, that in itself will be a gigantic leap forward as it would allow guys like myself to go in for a hair transplant and never worry about further loss or deal with effing finasteride/minox or other crap.

Same here.
I think they achieve great results already. Even Histogens results became better with time and Replicel just presented their 6 month results, it is possible that their results are far better than 6.1% or whatever it was.

Do you know any other treatments, does not have to be something regarding hair loss, that was already partially released during this period?
Does anyone know where to search for this kind of things in the internet?

Release it already Replicel/Shiseido for ***** sake !! I wanna see an end to all this bull