Topical Cannabis sativa? -
+ Reply to Thread
Results 1 to 4 of 4
  1. #1
    Junior Member
    Join Date
    Jun 2014

    Default Topical Cannabis sativa?

    The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling. Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.

  2. #2
    Senior Member
    Join Date
    Nov 2013


    Well if smokin some bud helped hair loss, I wouldn't even be on the forum...

  3. #3
    Join Date
    Jun 2014


    just another petri dish study folks, keep walking

  4. #4
    Junior Member
    Join Date
    Mar 2021


    In the future, many researchers predict the legalization of hemp throughout America. After all, scientific experiments that prove the healing effect of the plant provoke the appearance of fashionable trends. This is a useful thing, you can buy it here cbc oil. So cannabidiol began to be added to pet foods, alcoholic ****tails, and hemp oil is actively used as a dressing for salads.

Similar Threads

  1. Topical Fin or Dut
    By NeedHairASAP in forum Hair Loss Treatments
    Replies: 1
    Last Post: 09-28-2013, 05:56 PM
  2. topical fin?
    By swingline747 in forum Hair Loss Treatments
    Replies: 10
    Last Post: 09-23-2013, 12:25 AM
  3. RU=Topical Fin?
    By Hairismylife in forum Hair Loss Treatments
    Replies: 0
    Last Post: 08-24-2012, 12:39 AM
  4. Synthetic Cannabis
    By Samiam in forum Men's Hair Loss: Start Your Own Topic
    Replies: 0
    Last Post: 05-21-2011, 03:00 PM
  5. topical fin???
    By thejdizzle in forum Hair Loss Treatments
    Replies: 0
    Last Post: 04-28-2010, 02:06 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts


hair transplant surgeons

» The Bald Truth

» Recent Threads

LIVE Q&A with Spex via Instagram 12pm noon GMT | 22nd April
04-22-2020 12:19 AM
by Spex
Last Post By Beris
Today 11:35 AM
What makes a good candidate for Hair Transplant surgery?
09-09-2015 01:59 AM
by Spex
Last Post By Grace
Today 08:15 AM
7 year fine hairline results by Dr Lindsey
Today 07:15 AM
Last Post By Dr. Lindsey
Today 07:15 AM
No Shave Fue
07-03-2022 08:11 PM
by TexEx89
Last Post By TexEx89
07-03-2022 08:11 PM
Two consultations, two opposing opinions?
07-03-2022 10:55 AM
by JFR
Last Post By JFR
07-03-2022 10:55 AM