Topical Cannabis sativa? - BaldTruthTalk.com
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  1. #1
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    Default Topical Cannabis sativa?

    http://www.ncbi.nlm.nih.gov/pubmed/25061872

    The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling. Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris.

  2. #2
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    Well if smokin some bud helped hair loss, I wouldn't even be on the forum...

  3. #3
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    just another petri dish study folks, keep walking

  4. #4
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    In the future, many researchers predict the legalization of hemp throughout America. After all, scientific experiments that prove the healing effect of the plant provoke the appearance of fashionable trends. This is a useful thing, you can buy it here cbc oil. So cannabidiol began to be added to pet foods, alcoholic ****tails, and hemp oil is actively used as a dressing for salads.

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