Dr Lauster's Team (Berlin University of Technology)

[Desmond84]

Thanks Desmond, that was a well written, well thought out, and informative post. Also thanks for your hard work. Either way we all live in an era where medical progress is probably going to help every one of us in some way, whether it is hair related or not. I'm happy to know that if I have a son, he won't have many worries as far as hair nonsense is concerned, and I think there are much bigger things to worry about, like the state of the world and the environment in general.

I am really curious to know whether the hair seeds that they have already made would grow into hair on someone's head as they are, but I guess the want to get them even more perfected before they try that. It's curious to think what exactly is holding the seeds back from becoming full hairs. I wrote an email to Gardner a few months ago where I asked him why they aren't growing DP cells in tiny chambers coated with epithelial cells, and then watched that Beren Atac video to see that she is doing precisely that Made me smile.

Yeah...I can't believe either the luck we have! Out of all the cell lines, DP cells are the most difficult ones to culture. At least each team is taking a different approach, we'll see who is right soon enough co-culturing endothelial cells vs. specific growth factors!

Btw, how awesome are the german team...they're doing everything right so far...I had a smile on my face watching the presentation as well

hey desmond,

you mentioned that their bioengineered follicles are currently not terminal yet, only vellus-like hairs. so i assume they never tried to implant those follicles into human scalp yet, what do you think?

but what if this micro follicle is already enough to trigger further mechanisms after implantation? what if the follicle starts to grow, or if it triggers the surrounding cells to strengthen the follicle? did they ever tested it to see the outcome? or do they need official trials for that, which is not going to happen before they create terminal hairs.

implanting those vellus-like hair would also show some other aspects, e.g. does the hair stay in vellus condition or does it fall out immediately? or what happens to that implanted follicle in general? see some reactions etc. would be interesting. it's completely different than playing the in-vitro game only...

hahahha, oh if only we could have some guinea pigs to test that! wouldn't that be wonderful! LOL

I personally think it's worth a shot...you can even use Histogens HSC on them afterwards. We know HSC is capable of turning vellus hairs to terminal. But I guess they don;t wanna rush it and instead have a solid product especially if the vellus hairs were incapable of turning terminal! imagine the millions of dollars that would have been wasted on human trials! We'd have another Aderans on our hands

[joachim]

Yeah...I can't believe either the luck we have! Out of all the cell lines, DP cells are the most difficult ones to culture. At least each team is taking a different approach, we'll see who is right soon enough co-culturing endothelial cells vs. specific growth factors!

Btw, how awesome are the german team...they're doing everything right so far...I had a smile on my face watching the presentation as well




hahahha, oh if only we could have some guinea pigs to test that! wouldn't that be wonderful! LOL

I personally think it's worth a shot...you can even use Histogens HSC on them afterwards. We know HSC is capable of turning vellus hairs to terminal. But I guess they don;t wanna rush it and instead have a solid product especially if the vellus hairs were incapable of turning terminal! imagine the millions of dollars that would have been wasted on human trials! We'd have another Aderans on our hands

i wonder if they test some of those created follicles internally on the staff themselves, or would that be illegal already? of course, it shouldn't be a huge trial to test that, only a handful volunteers to see what the implanted follicles do.

however, even if they manage to create terminal hairs in vitro there is no guarantee that those will grow in the scalp. would be interesting to hear from them what they think about the sebaceus gland dilemma? do they also hope that the implanted follicle triggers some neogenesis and that the seb. gland is formed naturally?

man, what if those terminal hairs don't work at all when they implant them? so many untested and unknown scenarios. they really should get some guinea pigs for some first tests...

[nameless]

hey desmond,

you mentioned that their bioengineered follicles are currently not terminal yet, only vellus-like hairs. so i assume they never tried to implant those follicles into human scalp yet, what do you think?

but what if this micro follicle is already enough to trigger further mechanisms after implantation? what if the follicle starts to grow, or if it triggers the surrounding cells to strengthen the follicle? did they ever tested it to see the outcome? or do they need official trials for that, which is not going to happen before they create terminal hairs.

implanting those vellus-like hair would also show some other aspects, e.g. does the hair stay in vellus condition or does it fall out immediately? or what happens to that implanted follicle in general? see some reactions etc. would be interesting. it's completely different than playing the in-vitro game only...

I think you have a good point. I think they should implant the follicles now as they are to see what happens. They could add growth factors by way of adding the AAPE extract mentioned in the adipose stem cell study. They don't need histogen.