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yes I am sure I read it. actually I found it in one of his patents, and I qoute:
"FSCs generate new hair follicles that preserve the type of hair follicle that is typical for each location of skin or scalp. For example, FSCs from the coronal scalp of a male with MPHL typically generate atrophic follicles with vellus or club hairs. In contrast, FSCs from the occipital scalp of the same male typically generate follicles with terminal hair that are not subject to involution in response to DHT.
However, if external signals are provided that interfere with this “default” program, the FSCs responsible for follicle formation may be reprogrammed. FSCs in the process of asymmetric division and subsequent differentiation are susceptible to signals (such as estrogen or testosterone) that alter their differentiation program. For example, FSCs from the coronal scalp of a male with MPHL, under the influence of estrogen, can generate follicles with terminal hair that are not subject to involution in response to DHT. Such follicles have characteristics usually associated with: (i) pre-alopecia folliclcs in the coronal scalp; (ii) female-type follicles on the coronal scalp; or (iii) occipital scalp type follicles. Alternatively, by antagonizing estrogen or testosterone, the assumption of the default hair pattern in a particular skin area may be prevented. For example, a female's unwanted moustache hair may be reduced by perturbing the skin of the upper lip and administering a testosterone antagonist."
Link: https://www.google.com/patents/US201...ed=0CBwQ6AEwAA
FSC means follicle stem cells
topical estrogen is used in europe for hair loss for both men and women according to this link:
http://www.****************/hair-los...article340.phpComment
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We've been having a lot of great posts on the scientific progress on hair loss. Desmond's trip has certainly paid off. Unfortunately, a true cure looks to be some time off but it's coming--there are enough very smart people working hard on it. Unless something comes out of left field, we are stuck with the current treatments for the next few years. The best hope for the next two years is pilofocus. At least you could get a hair transplant without a scar and maybe there's regeneration. In many ways, it's the perfect stopgap until a cure.Comment
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Any updates regarding piloscopy? That seemed promising when I went to ISHRS conference in 2013.AfterHair is a patient advocate for Dr. Parsa Mohebi
AfterHair's regimen includes:
HT #1 2710 grafts by Dr Parsa Mohebi in Los Angeles, CA in 2012
Rogaine foam 2xdaily, since 2012
Finasteride 1.25mg daily, since 2012
sigpicComment
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CB and Histogen are the only new treatments that can come out within the next five years. I don't believe CB will break new ground in terms of results, since I don't see how it can be any more effective than something like Dutasteride. We already know the limits of DHT inhibitors. It will be good for people who can't take the pill, but that's it. Not to mention we're talking about a potentially messy topical that has to be applied who knows how many times and left on for who knows how long. I think Histogen will be a game changer in hair restoration. It won't restore hair to a NW7, but from I've seen I'm confident that with enough treatment sessions it can restore hair to a NW3 or NW2 who has minimal to no crown thinning. And it will maintain all your hair with routine injections every year or so. That's a big improvement over Fin/Minox which have to be taken daily and most likely won't touch the results that injected growth factors can produce.
Replicel in theory might be even better than Histogen, but it is a decade away at least. God knows what Follica is doing. One day they say their wounding protocol produces substantial new hairs, then the next day they say they are barely better than current treatments. Seems like a contradiction to me. And all the other research right now is aimed towards implanting lab grown hair, which is NOT a freaking cure. Might as well get a HT now if you want hair that doesn't look like what you used to have.Comment
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none.Comment
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Yeah, Cots said the same back in 2007/8.
Nothing on the horizon for the next 10 yrs. Maybe pilofocus will be an advancement but it's not much more than scarless HT. Replicel is working with cells that are genetically compromised, the results are in the 5-15% range at best. That's IF they even make it to market which is highly unlikely. Histogen is dead in the water, haven't advanced one inch in the past two years. This can only lead one to the conclusion that their results were not that great; otherwise money would be floating in and new trials would've begun. Follica is finished... they released all of their staff including the ceo and have now turned management back over to puretech, which is a very bad sign. Maybe CB will come through but we all are well aware of the limitations of DHT based treatments.
Feels like science has failed us.I've been around boards like this for a long time. A very long time - over ten years. And i've never felt as bad about the prospect of a good treatment or cure as i do now.
It's over johnny, it's over.Comment
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what a tough crowd
What reason do you have to doubt Cotsarelis?
Look, he said it right here:
"Cotsarelis says the for-profit venture is now only doing preclinical experiments, but if all goes perfectly, there could be a product on the market in two to three years."
Hmmm, he said that in a Scientific American article in May of 2007.
Soooooo, the way I see it there's a good chance we should have a product available by the Spring of 2009 or 2010. Ok, I will give him another two years just to play it safe. It will be available by the spring for 2012. Count on it.
Wait, what year is right now? I'm terrible with dates and time.Comment
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Hellouser was clearly being sarcastic people.Comment
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