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  1. #1
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    Default new method for stem cell differentiation

    New method reveals single protein interaction key to embryonic stem cell differentiation

    http://www.sciencedaily.com/releases...cienceDaily%29

    something for Dr. Xu I guess as he is trying to convert the iPS cells into dermal papilla cells.
    maybe this new method will speed up his research.

  2. #2
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    Quote Originally Posted by joachim View Post
    New method reveals single protein interaction key to embryonic stem cell differentiation

    http://www.sciencedaily.com/releases...cienceDaily%29

    something for Dr. Xu I guess as he is trying to convert the iPS cells into dermal papilla cells.
    maybe this new method will speed up his research.

    Does Dr. Xu know about this?

  3. #3
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    Quote Originally Posted by nameless View Post
    Does Dr. Xu know about this?
    hard to say. the sooner or later he will definitely hear or read about it.
    but i'm too always wondering, if all the researchers get the latest infos somehow automatically or do they also have to read the news like us? i could imagine that researchers have their own special sources, or maybe a kind of network where they get forwarded the info. but what if not? what if such news doesn't get noticed by some researchers? would be a pity. i think researchers also have to be proactive and read as much as possible about the latest medical discoveries.

    maybe sdsurfin should ask Dr. Xu about this as a general question. would be interested to hear if they have some automatism to receive the latest news.
    and we can also ask Dr. Gardner about it.

  4. #4
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    Quote Originally Posted by joachim View Post
    hard to say. the sooner or later he will definitely hear or read about it.
    but i'm too always wondering, if all the researchers get the latest infos somehow automatically or do they also have to read the news like us? i could imagine that researchers have their own special sources, or maybe a kind of network where they get forwarded the info. but what if not? what if such news doesn't get noticed by some researchers? would be a pity. i think researchers also have to be proactive and read as much as possible about the latest medical discoveries.

    maybe sdsurfin should ask Dr. Xu about this as a general question. would be interested to hear if they have some automatism to receive the latest news.
    and we can also ask Dr. Gardner about it.
    There are plenty of services that allow you to subscribe to topics and alert you whenever a paper is published in the field (Google Scholar for example). It is very unlikely that a relevant paper goes unnoticed by someone working in a closely related area (the first thing one does is embark on an extensive literature review). Often groups are in close communication (collaborating, or have contacts from conferences etc) and are ahead of the publishing curve.

  5. #5
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    Quote Originally Posted by walrus View Post
    There are plenty of services that allow you to subscribe to topics and alert you whenever a paper is published in the field (Google Scholar for example). It is very unlikely that a relevant paper goes unnoticed by someone working in a closely related area (the first thing one does is embark on an extensive literature review). Often groups are in close communication (collaborating, or have contacts from conferences etc) and are ahead of the publishing curve.
    i hope so.

    however, would be nice to verify it for some cases.

  6. #6
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    Quote Originally Posted by joachim View Post
    i hope so.

    however, would be nice to verify it for some cases.
    I agree.

    I had a friend who was dying a few years ago of a disease and I talked to his attending doctor about a new treatment that was available to the general public already. The doctor said that my friend's condition was too far advanced for that treatment to work. He said that the medicine does not work in advanced cases like my friend's. I told him that a very recent study showed that the medicine does work in a small percentage of the people who have advanced cases. He told me he would look into it. He later told me that I was right, he thanked me for bringing the information to his attention, and he put my friend on the treatment. The treatment didn't work and my friend died. But that's not the point. The point is that my friend's doctor was a teaching doctor at a big university. He worked at the University of Arizona Medical Center. He taught at the college and practiced at the hospital at the time.

    The thing is that these scientists have other lives besides their research and they can't keep up with everything. The study was out on medline for about 3months and the doctor did not know about it.

    If someone is in email contact with Dr. Xu I think that person should let Dr. Xu know about this.

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    i'm sorry for your friend. i also experienced some similar cases. many doctors don't give a shit about keeping up with the latest findings, medications, therapies, etc.
    sometimes it seems to me that once they reach a certain age they're not interested in learning new stuff anymore. they just keep doing their same work for decades. like many of you also noticed, there are only few general practitionars and even dermatologists who know about hairloss treatments at all. all they know is prescribe Fin and Minox but they even don't know about long term sides of Fin.
    however, i think the situation for researchers is a bit different. i hope they are eager enough to keep up with all the latest discoveries. but of course, there are definitely also many researchers where this isn't the case.

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    sdsurfin, if you read this:

    are you still in contact with Dr. Xu?
    is it possible to forward some questions to him?
    i'm interested in his epithelial conversion process via iPS cells and his further steps with DP cells, especially in terms of gene expression. i can't stop thinking about the crowdfunding idea. i think it would be good to have more parallel ways to get to the cure.

    what if all researchers are trying to improve DP gene expression and inductivity over the next years but nobody is able to achieve it? what if, in 3 years, we are at the same point as we are today? or what if they are able to achieve more gene expression (e.g. 70% or more) but it turns out that it's still not enough. what if all those culturing techniques doesn't lead to success? then we're really screwed and lost again some years for nothing. and if you think of it: the chance that this could happen is really there.

    so i think, the parallel approach by creating unlimited DP cells from iPS cells seems promising. i also don't see why Dr. Xu won't be able to figure out the right conversion within 2 or 3 years. basically it's trial and error with several different proteins/doses/timeframes.

    however, there is still a hurdle: Xu mentioned he created the iPS stemcells by gene editing, which is no applicable solution. in the meantime, someone has also to work on a method to create iPS cells. the recently popped up method (converting blood with some kind of acid) was officially retracted, thus proven to be fake.
    so, someone has to find a method for this (or does anybody know if there is a legal method of creating iPS cells already?).
    however, this is a generel problem on which many scientists all over the world are working already (as it is not only hairloss releated). creating iPS cells is the crucial basis for every future stem cell therapy.

    would be good if we can forward some questions to him or maybe he is willing to answer some questions directly here in the forum, like Dr. Gardner.

    at first i thought it's not that interesting anymore in crowdfunding Dr. Xu's method but the more i think about it i get to the conclusion that this is a very good backup plan if all other researchers fail.
    however, if in the next months it turns out that the chinese or some other labs are already able to culture DP cells with 100% expression then, of course, the crowdfunding step wouldn't make that much sense anymore, or would lose priority respectivelly. on the other hand, it should be the ultimate goal for science to be able of creating EVERY specific cell type somewhen in future anyway.

  9. #9
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    Quote Originally Posted by joachim View Post
    sdsurfin, if you read this:

    are you still in contact with Dr. Xu?
    is it possible to forward some questions to him?
    i'm interested in his epithelial conversion process via iPS cells and his further steps with DP cells, especially in terms of gene expression. i can't stop thinking about the crowdfunding idea. i think it would be good to have more parallel ways to get to the cure.

    what if all researchers are trying to improve DP gene expression and inductivity over the next years but nobody is able to achieve it? what if, in 3 years, we are at the same point as we are today? or what if they are able to achieve more gene expression (e.g. 70% or more) but it turns out that it's still not enough. what if all those culturing techniques doesn't lead to success? then we're really screwed and lost again some years for nothing. and if you think of it: the chance that this could happen is really there.

    so i think, the parallel approach by creating unlimited DP cells from iPS cells seems promising. i also don't see why Dr. Xu won't be able to figure out the right conversion within 2 or 3 years. basically it's trial and error with several different proteins/doses/timeframes.

    however, there is still a hurdle: Xu mentioned he created the iPS stemcells by gene editing, which is no applicable solution. in the meantime, someone has also to work on a method to create iPS cells. the recently popped up method (converting blood with some kind of acid) was officially retracted, thus proven to be fake.
    so, someone has to find a method for this (or does anybody know if there is a legal method of creating iPS cells already?).
    however, this is a generel problem on which many scientists all over the world are working already (as it is not only hairloss releated). creating iPS cells is the crucial basis for every future stem cell therapy.

    would be good if we can forward some questions to him or maybe he is willing to answer some questions directly here in the forum, like Dr. Gardner.

    at first i thought it's not that interesting anymore in crowdfunding Dr. Xu's method but the more i think about it i get to the conclusion that this is a very good backup plan if all other researchers fail.
    however, if in the next months it turns out that the chinese or some other labs are already able to culture DP cells with 100% expression then, of course, the crowdfunding step wouldn't make that much sense anymore, or would lose priority respectivelly. on the other hand, it should be the ultimate goal for science to be able of creating EVERY specific cell type somewhen in future anyway.
    There's no way in hell I'm suggesting to Dr. Xu that he should go on this forum. most of the questions on here are borderline braindead, and people keep asking the same stuff over and over seemingly without reading (or maybe understanding) what dr. gardner said. I'm not surprised he hasn't been on here in a while. As far as what Xu is doing, I think it will be more effective that trying to expand DP cells in culture and then re-instating their gene expression. O bviously he thinks the same, but we could both be wrong.

    I think crowdfunding just about anyone would be a doable and useful thing for this forum to do. I just read an article that said that 1 out of 5 people in britain said they would want to see a baldness cure if they could choose one thing for future experimentation to bring (out of any possible future device, tech, etc)!!! a ton of people want this to happen, which is why it's absolute bollocks when someone on here say that society is trying to keep a cure away, researchers dont want it etc etc. Humans are vain and people hate losing their hair, it's just a very hard thing to fix. lots of things involved as we've seen.

    I'm keeping Dr. Xu posted with those videos, and I'm sure he's aware of all the stem cell news and techniques coming to fruition. I saw an article yesterday about how they figured out how to make liver cells turn back into stem cells (the liver is a very regenerative organ). I will ask Dr. Gardner and dr xu whether they read this and if they think it has any correlation. These guys are pros though, we're not gonna blow their minds with our knowledge, the best we can do is try to raise money and support. I don't spend a ton of time on here cause i have a life to live, but there are some guys on here who, if they spent a fraction of the time that they spend on here instead setting up a charity for hair loss or fundraising effort etc, would accomplish so much. Dr. Gardner outlined some very useful ways to garner support and money.

    I'm still waiting on Xu to hear back about crowdfunding from his university. I honestly think that the germans and the japanese are the most advanced, with perhaps dr gardner and dr xu in second. it doesnt seem like the germans or japanese are lacking funding. I think getting money to one of the american or british university teams would be hugely useful. depending on the amount raised, it could be split between the two. Crowdfunding a project like follica is stupid. that is a company that is in charge of securing their own funding, and if they cant do it, it means there's a good reason. you dont throw more money behind bad money. basic business. the goal is to get people enthused about the road to a real and permanent cure, which right now seems to be very realistically taking shape in the form of lab grown follicles.

  10. #10
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    Quote Originally Posted by joachim View Post
    like many of you also noticed, there are only few general practitionars and even dermatologists who know about hairloss treatments at all. all they know is prescribe Fin and Minox but they even don't know about long term sides of Fin.
    however, i think the situation for researchers is a bit different. i hope they are eager enough to keep up with all the latest discoveries.
    Yes, a clinical doctor has a very different role to a researcher with a PhD.

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