+ Reply to Thread
Page 10 of 10 FirstFirst ... 8 9 10
Results 91 to 91 of 91
  1. #91
    Junior Member
    Join Date
    Jan 2014
    Posts
    10

    Default OC459 not PGD2 inhibitor

    Quote Originally Posted by bradpitthair View Post
    OC459 is a PGD2 inhibitor

    High levels of PGD2 present in asthma patients, so a plausible solution here is to inhibit PGD2, which is what Atopix therapeutics has done with OC459. The results are here:

    http://www.atopixtherapeutics.co.uk/...aai-poster.pdf

    High levels of PGD2 present in MPB on the scalp

    Atopix site does not say it is specifically a PGD2 inhibitor. It is a CRTH2 receptor blocker, and PGD2 does bind to that receptor but it isn't the receptor in the hair follicle, the presentation says they tested 3 receptors and it is GPR44 receptor in the hair follicle which responds to PGD2 by inhibiting hair growth. They either need a GPR44 receptor antagonist, or something which blocks the COX2 enzyme from making the prostaglandin. But that might have wide ranging biological affects unless it is topical and doesn't become to systemic from absorption.

Similar Threads

  1. Dr. Cotsarelis interview about PGD2.
    By Sogeking in forum Cutting Edge / Future Treatments
    Replies: 11
    Last Post: 04-15-2017, 02:37 PM
  2. Mercks developing PGD2 Blocker!
    By Desmond84 in forum Cutting Edge / Future Treatments
    Replies: 21
    Last Post: 07-22-2015, 06:38 AM
  3. Has anybody stopped there hairloss with pgd2 blocker
    By thechamp in forum Cutting Edge / Future Treatments
    Replies: 11
    Last Post: 08-27-2013, 11:46 AM
  4. PGD2 Blocker is now available on mpbtreatments
    By HARIRI in forum Cutting Edge / Future Treatments
    Replies: 8
    Last Post: 06-01-2013, 03:47 AM
  5. Theoretically, would PGE2 stimulation+ PGD2 inhibition+ DHT inhibition= growth?
    By rdawg in forum Cutting Edge / Future Treatments
    Replies: 2
    Last Post: 12-07-2012, 08:29 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

» IAHRS

hair transplant surgeons

» The Bald Truth

» Recent Threads

On fin/ 17 yrs old
Yesterday 08:26 PM
by connor
Last Post By GroughBack
Today 01:23 PM
Does Rogaine (Minoxidil 5%) really work?
02-12-2012 09:43 PM
Last Post By GroughBack
Today 01:01 PM
I Hated My Hairline, So I Got a New One
Today 08:43 AM
Last Post By rbernstein
Today 08:43 AM
Cutting Edge Update Suggestion.
09-19-2017 11:48 PM
by Brianf
Last Post By keepyourhair
Today 06:52 AM
Hair today, gone tomorrow. Starting the war on hair loss!
08-11-2014 11:13 AM
Last Post By sabercbm
Today 05:17 AM