Anyone had success with PRP?

[35YrsAfter]

Good, so we have established then that your PGD2 'theory' is unsupported by actual science. Anyone can say they have a theory that there are fairies on the moon, but that doesn't make it creditable.

Nope, that wasn't established. Multiple articles on the PubMed.gov Website (US National Library of Medicine National Institutes of Health) state that PGD2 inhibits platelet aggregation. One example, read the last paragraph here.

Studies indicate that miniaturizing follicles are saturated with high concentrations of PGD2 whereas follicles in the "safe" zone on the same guy do not have those concentrations of PGD2. Platelet rich plasma increases the hair shaft diameter of miniaturized hair. To me, this observation is worthy of further investigation:

"We show a close temporal relationship between elevations in both Ptgds mRNA and PGD2 levels in mice with hair follicle regression during normal hair follicle cycling. We further provide functional data indicating that PGD2 and its nonenzymatic metabolite, 15-deoxy-Δ12,14-prostaglandin J2 (15-dPGJ2), inhibit hair growth in both mouse and human hair follicles. In mice and humans, the PGD2-mediated inhibition of hair growth required the G protein (heterotrimeric guanine nucleotide–binding protein)–coupled receptor 44 (GPR44), but not the prostaglandin D2 receptor 1 (PTGDR). Finally, we describe a mouse model (K14-Ptgs2) with elevated PGD2 levels in the skin that phenocopies human AGA (14). These results implicate PGD2 in the pathogenesis of AGA and suggest new receptor targets for its treatment."

Dr. Cole began using PRP during hair transplant surgeries, because it speeds and improves healing. Every patient who comes in for hair transplant surgery with adequate hair length gets cross section trichometry. Cross section trichometry is validated as a legitimate method of determining hair mass here on the US National Library of Medicine National Institutes of Health Website.

We keep every patient's hair mass index saved in a spread sheet. In about 90% of all cases where PRP/ACell was administered during their hair transplant surgery, we later see some increase in the hair mass index.

From the US National Library of Medicine National Institutes of Health:

http://www.ncbi.nlm.nih.gov/pubmed/22455565

"BACKGROUND:
Recently, autologous platelet-rich plasma (PRP) has attracted attention in various medical fields, including plastic and orthopedic surgery and dermatology, for its ability to promote wound healing. PRP has been tested during facelift and hair transplantation to reduce swelling and pain and to increase hair density.
OBJECTIVE:
To investigate the effects of PRP on hair growth using in vivo and in vitro models.
METHODS:
PRP was prepared using the double-spin method and applied to dermal papilla (DP) cells. The proliferative effect of activated PRP on DP cells was measured. To understand the mechanisms of activated PRP on hair growth, we evaluated signaling pathways. In an in vivo study, mice received subcutaneous injections of activated PRP, and their results were compared with control mice.
RESULTS:
Activated PRP increased the proliferation of DP cells and stimulated extracellular signal-regulated kinase (ERK) and Akt signaling. Fibroblast growth factor 7 (FGF-7) and beta-catenin, which are potent stimuli for hair growth, were upregulated in DP cells. The injection of mice with activated PRP induced faster telogen-to-anagen transition than was seen on control mice.
CONCLUSIONS:
Although few studies tested the effects of activated PRP on hair growth, this research provides support for possible clinical application of autologous PRP and its secretory factors for promotion of hair growth."

Another from the US National Library of Medicine National Institutes of Health:
Quote:
"The beneficial effects of PRP in AGA can thus be attributed to various platelet-derived growth factors causing improvement in the function of hair follicle and promotion of hair growth. It is safe, cheap, and non-allergic and it appears to be a useful adjuvant in the management of AGA."

My theory... Perhaps PGD2 plays a role leading to a deficiency in platelet growth factors necessary for healthy hair growth. In the better cases where PRP is administered, we see miniaturizing hair shaft diameter improve significantly.


35YrsAfter also posts as CITNews and works at Dr. Cole's office - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011
The contents of my posts are my opinions and not medical advice