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Originally Posted by Boldy
If i stand correct: wnt agonist works the same way as wnt's, they need the LRP5/6 + frizzled receptor to phosphorylze GSK3b, so that B-cetanin can be trans located to the nuclies, and genes such as tcf(important for hair growth), can be activated.
now in aga we many inhibitors one of the is DKK1 which block the above mentioned receptor where wnt does its work. GSk3b inhibitors like vpa or more selective 6BIO , don't need the frizzeled + lrp5-6 receptors, it enters the cell, and immediately starts gsk3b phosphorylation of GSK3 that leads to b-cetanin accumulation and translocation to the nuclies(what we need). so it is a shortcut and it overrules the inhibitory effect of dkk1. it is why i believe that gsk3b inhibitors have more potential in vivo.
Block DKK1 anyway along with DHT. I doubt full regrowth is possible but should be good for SOME reversal and at least long term maintenance.
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Guys they will start having Phase 2 clinical trials. Let's get the word out so members of the community can participate. Maybe Spencer Kobren can look into giving this publicity.
http://www.clinicaltrials.gov/ct2/sh...75351#contacts
Remember, you cannot be on any HL meds if you want to be part of the trial.
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When will those clinical trials start? Would be great if someone from the board will sign up to it .
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This is great news! So now we have CB and SM in phase 2 trials. Replicel and Histogen still going at it. Good things on the way guys!
Hopefully SM keeps us up to date with the trials.
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Study is starting next month! Move fast!
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any promising results from their phase 1?
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Not much interest for this huh. Odd, given all the hate finasteride gets on this forum.
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Originally Posted by KO1
Not much interest for this huh. Odd, given all the hate finasteride gets on this forum.
I was thinking the same. This stuff seems to be our only chance to have a more than decent regrowth agent in the coming years.
Also the Phase II trial is recruiting 300 participants, which shows how well funded they are.
I recall reading somewhere they had some sort of agreement with Pfizer.
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What's the agent/chemical thats the WNT agonist???
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Originally Posted by inbrugge
any promising results from their phase 1?
+1, where are the phase I results?
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