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Thread: Sm04554

  1. #11
    Senior Member Desmond84's Avatar
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    Quote Originally Posted by Jens1986 View Post
    PSK 3841, a nonsteroidal
    antiandrogen, has completed phase IIa
    trials for the treatment of androgenetic
    alopecia and a clinical proof-of-concept
    study to reduce sebum flow and
    secretion in patients with acne. Six
    months of treatment with PSK 3481
    demonstrated equivalent or better net
    hair growth compared with finasteride.

    Source: «Drug News» Vol. 13, No. 13 March 2004
    Wow 2004! How depressing :'( All our problems would have been solved if this came out...sigh

    Let's just hope we don't add Histogen to this list. They've now been silent for 15 months after completion of Phase 2a

  2. #12
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    Interesting, its a shame I'm only a nw 2/3 otherwise I would apply as I am close to the area.

    Isn't Desmond from Australia or the oceanic region? Or was another forum regular

    Edit: Here's another one...RK-023. There is not much info on it but its currently being trialed on eye lashes with the intended effect to turn velus hairs into something more so it seems.

  3. #13
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    Quote Originally Posted by huawei View Post
    Interesting, its a shame I'm only a nw 2/3 otherwise I would apply as I am close to the area.

    Isn't Desmond from Australia or the oceanic region? Or was another forum regular

    Edit: Here's another one...RK-023. There is not much info on it but its currently being trialed on eye lashes with the intended effect to turn velus hairs into something more so it seems.
    Seems phase IIa was complete in januari 2011:
    The completion of the Phase 2a clinical study of RK-023 for the treatment of androgenetic alopecia has been announced in January 24th, 2011.
    http://www.businesswire.com/news/hom...3#.UvuptfldW1s

    Although it seems they made a new formula of Rk-023, as they started Phase I in February 2011.

    Don't know why, but it's automatically changed to dutch.
    http://www.news-medical.net/news/201...096/Dutch.aspx

  4. #14
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    Quote Originally Posted by Desmond84 View Post
    Wow 2004! How depressing :'( All our problems would have been solved if this came out...sigh

    Let's just hope we don't add Histogen to this list. They've now been silent for 15 months after completion of Phase 2a

    PSK 3841 = RU 58841, got renamed after Roussel Uclaf sold it to ProStrakan.

    It was just to show hellouser that RU made it past Phase I

  5. #15
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    Quote Originally Posted by Jens1986 View Post
    PSK 3841 = RU 58841, got renamed after Roussel Uclaf sold it to ProStrakan.

    It was just to show hellouser that RU made it past Phase I
    It still got shelved in the end. Nothing to be happy about.

  6. #16
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    Quote Originally Posted by hellouser View Post
    It still got shelved in the end. Nothing to be happy about.
    You are always so negative. It got shelved cus its not stable enough and/or they didnt think it was good enough for production, fin was allready on the marked and its easier to just take a pill. Its easy to get RU, and if it wasnt for Roussel Uclaf/ProStrakan we would not have RU as an option. Researhers/scientists are helping a lot of us, stop complaining about everything pls it just makes u look like a whiner. "omgomgomg if we were women this would have been fixed a long time ago, the world dont give a shit about men"

  7. #17
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    Phase 2 for Samumed SM04554 now posted on clinicaltrials.gov. Multiple US sites listed, not yet recruiting, androgenetic alopecia.

    http://www.clinicaltrials.gov/ct2/show/NCT02275351

  8. #18
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    Quote Originally Posted by thinning44 View Post
    Phase 2 for Samumed SM04554 now posted on clinicaltrials.gov. Multiple US sites listed, not yet recruiting, androgenetic alopecia.

    http://www.clinicaltrials.gov/ct2/show/NCT02275351
    I'm very curious. We know the WNT/b-catenin pathway plays a immense role in hairloss. Hopefully this direct agonist of the WNT pathway will do a better job than minox for example as a growth agent.

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    Quote Originally Posted by Swooping View Post
    I'm very curious. We know the WNT/b-catenin pathway plays a immense role in hairloss. Hopefully this direct agonist of the WNT pathway will do a better job than minox for example as a growth agent.
    it also play a role in the adipose cells differentiation: http://www.pnas.org/content/111/15/E1501.abstract

    and we know that the fatty tissue ;required also for hair growth; on our scalps is thinning as we lose our hair.

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    If i'm correct : wnt agonist works the same way as wnt's, they need the LRP5/6 + frizzled receptor to phosphorylze GSK3b, so that B-cetanin can be trans located to the nuclies, and genes such as tcf(important for hair growth), can be activated.

    Now in aga we many inhibitors one of the is DKK1 which block the above mentioned receptor where wnt does its work. GSk3b inhibitors like vpa or more selective 6BIO , don't need the frizzeled + lrp5-6 receptors, it enters the cell, and immediately starts gsk3b phosphorylation of GSK3 that leads to b-cetanin accumulation and translocation to the nuclies(what we need). so it is a shortcut and it overrules the inhibitory effect of dkk1. it is why i believe that gsk3b inhibitors have more potential in vivo.

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