Clinical trial starting using Jahoda's method !

[Arashi]

In this article:

http://www.dailymail.co.uk/health/article-2551177/Bald-Now-theres-jab-make-hair-grow-back.html

They mention Jahoda's method but more interesting, they mention that a clinical trial is starting in Taiwan, using his breakthrough finding from last year:

Now the first human study is underway in Taiwan with around 400 men and women. Patients who are undergoing cosmetic surgery at the National Taiwan University Hospital are providing samples of dermal papillae cells from their scalps. These will then be cultured in the lab and implanted into bald patients.

Not sure who's behind the trial and if they even are going to try to improve Jahoda's method, cause the hair he has grown wasn't cosmetically usuable yet. However, it's good news to see they're going to try it on 400 persons.

[hellouser]

Those 400 people should be 400 of us here in the forums. Lord knows we've made more of an effort to warrant a treatment than many others.

[Arashi]

Those 400 people should be 400 of us here in the forums. Lord knows we've made more of an effort to warrant a treatment than many others.

Well, unless they're going to try some new idea's, they're not going to get something aesthetically pleasing anyway (jahoda's generated hair lacked colour, thickness and correct angle). So those people are not getting really anything out of it. But from a research perspective this is a nice development. Of course it would be even (way) more interesting if they'd try some new idea's to retain more gene expression (and thus generate correct hair properties)

[Hicks]

Those 400 people should be 400 of us here in the forums. Lord knows we've made more of an effort to warrant a treatment than many others.

They'll give us the Placebo!

[youngin]

That quote makes it sound like they are taking DP's from 1 persons scalp and implanting them in another. Like Jahoda did with his wife. Not really a viable solution unless we are taking DP's off dying people head lol.

[Arashi]

That quote makes it sound like they are taking DP's from 1 persons scalp and implanting them in another. Like Jahoda did with his wife. Not really a viable solution unless we are taking DP's off dying people head lol.

No, what Jahoda did is take DP's and then culture them. I'm 100% sure they won't implant them in other people cause that will cause autoimmune reactions, so doesn't make any sense.

Take DP from person A, culture and implant it back in person A and hair grows.

[Imalmostbald]

http://clinicaltrials.gov/ct2/show/study/NCT00506636

Guess it takes long to get participants.. LOL.

[Thinning87]

Pardon me Arashi, but Jahoda's method was published relatively recently. This study was first initiated in 2007 (at least the beaurocratic procedures) so how is it possible that they would be using Jahoda's method if when they started they weren't even aware of his technology?

[Arashi]

Pardon me Arashi, but Jahoda's method was published relatively recently. This study was first initiated in 2007 (at least the beaurocratic procedures) so how is it possible that they would be using Jahoda's method if when they started they weren't even aware of his technology?

Well they ARE using Jahoda's technology, since until Jahoda's finding last year nobody could succesfully culture DP cells and the text states that's that what they are going to do in the trial. So it has to be Jahoda's finding, no way around it.

So, 2 explanations, either they are modifying that existing trial (not sure if that's even possible ?) or more likely, this is going to be an other trial than that current ongoing trial at that university.

[Thinning87]

Well they ARE using Jahoda's technology, since until Jahoda's finding last year nobody could succesfully culture DP cells and the text states that's that what they are going to do in the trial. So it has to be Jahoda's finding, no way around it.

So, 2 explanations, either they are modifying that existing trial (not sure if that's even possible ?) or more likely, this is going to be an other trial than that current ongoing trial at that university.

I see the second one would make sense. Well this is great news I didn't think they'd give it a try this early!

[Arashi]

I see the second one would make sense. Well this is great news I didn't think they'd give it a try this early!

Nope, me neither, although Jahoda said he thought they'd start 'soon' with trials, this is indeed a positive surprise for once

[Thinning87]

Well let's hope this is happening for real!

[Thinning87]

I read the article again, it does mention dp cells but it's not like a clear announcement that they will be using Jahodas method.

Frankly, I find it more likely that the journalist threw the term dp cells in there at random, and they are just referring to the old trial from 2007.

Dr. Christiano told in her interview that more work needed to be done to increase hair growth.

[Arashi]

I read the article again, it does mention dp cells but it's not like a clear announcement that they will be using Jahodas method.

Frankly, I find it more likely that the journalist threw the term dp cells in there at random, and they are just referring to the old trial from 2007.

Dr. Christiano told in her interview that more work needed to be done to increase hair growth.

Well, again, the only group of researchers who succeeded at culturing DP cells was Jahoda's group, so if the article is right, then they'll indeed use Jahoda's method. Of course the journalist could be wrong though, who knows ..

[southern]

Sung-Jan Lin, MD PhD

Sung-Jan Lin is the Clinical Trial principal Investigator

This is a patent under his name from 2013:

http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8492112.PN.&OS=PN/8492112&RS=PN/8492112

"Disclosed is a method for the manufacture of microtissues, comprising the steps of: providing a biomaterial substrate; simultaneously seeding a plurality of dermal papilla (DP) cells and keratinocytes on the substrate surface with a predetermined ratio and cellular density; co-culturing for a predetermined period; and carrying the keratinocytes to the substrate surface by the dermal papilla cells, aggregating and finally form a plurality of keratinocyte-dermal papilla cell microtissues, wherein the dermal papilla cells are located in a center of the microtissue and the keratinocytes are sorted to a surface of the microtissue, and the keratinocytes are adult keratinocytes. The method can help to simply and economize the procedures for production of folliculoid microtissues with high-throughput. Once microtissues are transplanted to skin of subject, hair follicles can be regenerated."

"The inventor of the present invention has previously reported that EVAL, containing both hydrophilic and hydrophobic domains, is a unique polymer that is able to enhance the self-assembly for DP cells into spheroidal microtissues that are able to induce HF morphogenesis"