Local Antiandrogen Therapy for the Treatment of Male Pattern Baldness

[beetee]

This does seem interesting. Tenma, I haven't seen the part talking about developing a formula with estrogen. Can you tell me where that's coming from? And could someone let me know where the 50% regrowth number is coming from?

[Tenma]

http://www.hygeiatherapeutics.com/portfolio.html

The name of the compound is HYG-102440.

This company was recently acquired by Stratus Media:

http://www.businesswire.com/news/rxt...ical-Companies

Unlike Histogen, they move forward with the merger.

Also, here you have the CB study showing amazing numbers:

http://www.cosmopharmaceuticals.com/...010-10-06.aspx

[LMS]

nice so we have 3 companies developing topical antiandrogens.

sucks tho that by the time you can buy them ill be bald as a cueball.

[hellouser]

nice so we have 3 companies developing topical antiandrogens.

sucks tho that by the time you can buy them ill be bald as a cueball.

Mash up Finasteride pills into a vehicle of your own then.

[kobefan234]

I really doubt that. There are so many existing treatments for acne its disgusting.

How many treatments are there for hair loss?

A WHOPPING TWO!

isotretinoin = cure for acne.

most dermatologists refrain from prescribing it.

[youngin]

isotretinoin = cure for acne.

most dermatologists refrain from prescribing it.

Good for them, because taken orally it can screw you up pretty good!

[hellouser]

isotretinoin = cure for acne.

most dermatologists refrain from prescribing it.

Reading about the side effects, isotretinoin looks pretty scary

[kobefan234]

Good for them, because taken orally it can screw you up pretty good!

yes, most dermatologists will have you believe that, giving 80 mg to a 150lb teen kid for sure "screw you up pretty good!". LOL

Reading about the side effects, isotretinoin looks pretty scary

when given in high amounts yes. The dose is dependent on body-weight. isotretinoin used at 20 mg per day for 5-6 months is a cure for acne for 95 % + people.

Low-dose isotretinoin in the treatment of acne vulgaris.
Amichai B, Shemer A, Grunwald MH.
Source
Huzot Clinic of Clalit Health Services, Ashkelon, Israel.
Abstract
BACKGROUND:
The efficacy of isotretinoin at 0.5 to 1.0 mg/kg per day in the treatment of acne is well established and considered safe, although it is sometimes not easily tolerated because of its cutaneous side effects.
OBJECTIVE:
The purpose of this study was to determine the efficacy of low-dose isotretinoin in the treatment of acne.
METHODS:
In this prospective, noncomparative, open-label study, 638 patients, both male and female, with moderate acne were enrolled and treated with isotretinoin at 20 mg/d (approximately 0.3-0.4 mg/kg per day) for 6 months. The patients were divided into two age groups: 12 to 20 and 21 to 35 years old. Patients were evaluated at 2-month intervals by means of clinical and laboratory examinations. A 4-year follow-up was also carried out.
RESULTS:
At the end of the treatment phase, good results were observed in 94.8% of the patients aged 12 to 20 years, and in 92.6% of the patients aged 21 to 35 years. Failure of the treatment occurred in 5.2% and 7.4% of the two groups, respectively. Twenty-one patients dropped out of the study because of lack of compliance, and another patient discontinued participation because of a laboratory side effect. During the 4-year follow-up period, relapses of the acne occurred in 3.9% of the patients aged 12 to 20 years and in 5.9% of the patients aged 21 to 35 years. Elevated serum lipid levels (up to 20% higher than the upper limit of normal value) were found in 4.2% of the patients and abnormal (<twice the upper limit of normal values) liver tests were observed in 4.8%.
LIMITATIONS:
This was a noncomparative, open-label study.
CONCLUSION:
Six months of treatment with low-dose isotretinoin (20 mg/d) was found to be effective in the treatment of moderate acne, with a low incidence of severe side effects and at a lower cost than higher doses.

[burtandernie]

It could act differently then a normal AA like propecia if you read the article. We only need one good safe topical AA whether this or CB to basically make MPB a preventable problem. Why its taken 20 years to get something like this since propecia I really dont know but better late then never

page 3 bright green letters
"By inhibiting androgen and PGD2 synthesis nitric
oxide may have multiple mechanisms that can be exploited to treat male pattern baldness."

[Tenma]

We only need one good safe topical AA whether this or CB to basically make MPB a preventable problem. Why its taken 20 years to get something like this since propecia I really dont know but better late then never

Its unbelievable the slow pace of AGA treatments. Apparently 2016/2020 its going to be this new "era" of topical antiandrogens. RU studies are from the early-mid 90s! Which means scientist and biotechs companies were both aware of how to prevent this ****in' problem.

Hell, since Hamilton studies we know the impact of androgen suppression on hair mantainance.

SB-204 will come sooner than CB, hopefully. They plan to present phase 2 results early next year. I'm a little angry with cosmo, though. they restarted trials with cb despite their phase two success in europe.

If we use this stuff together and maybe add finasteride we can certainly lower the androgen stimulus sufficient enough for a very long time.