An interesting possibility

[HairlossAt15]

Hey guys,

Cotsarelis has previously stated in this interview:

http://dermatologyfoundation.org/pdf/pubs/DF_Winter_2012.pdf

"The technology does not yet exist for
determining whether this pathological in-
crease in PGD 2 is responsible for inhibiting
stem cell activation in the bulge. Hair folli-
cle stem cells are finicky, and the culture
conditionsthatwouldenablethemtomain-
tain their stemness and induce growth of a
hair are unknown. Thus there is no way to
culturefunctionalhairfolliclestemcellsso
thatPGD 2 canbeaddedtoobservetheirim-
pact. When attempts are made to culture
hair follicle stem cells, they start to behave
likeinterfollicularkeratinocytes.Progenitor
cells haven’t even gotten that far—they re-
mainsteadfastlyresistanttoculture."
(sorry for bad format)
i.e. they could not add pgd2 to hair follicle stem cells as they did not act as they should outside of their natural environment.

Do you think with the recent hair follicle model developed this may now be possible?

http://www.asianscientist.com/in-the-lab/hair-follicle-model-accelerate-cure-baldness-2013/

It even says that it could be used to screen for novel drug compounds.

Could pgd2 be added its effects studied and then a GPR44 blocker added to see its effect as well? Also pge2 and other things i discussed here:http://www.baldtruthtalk.com/showthread.php?p=128172

[hellouser]

Do you think with the recent hair follicle model developed this may now be possible?
http://www.asianscientist.com/in-the...baldness-2013/

The miserably embarrassing part about that research is that health ministries (such as the FDA) would do everything in their power to make a commercial treatment jump through so many hoops (clinical trials) that it basically renders the finding and excitement completely useless for the next 5 or MORE years (its never been 'within 5 years'). It really is only exciting to low norwoods who can tolerate their current hair loss status OR to future bald men who are unaware of their balding condition but will surely benefit from future treatments that are bound to be superior than that piss poor piece of shit pill known as finasteride.

I would demand the treatment becomes available NOW rather than having us get SCREWED waiting for ages and having our condition only worsen and have ourselves live a life far less meaningful than those privileged with hair.

[clandestine]

I would demand the treatment becomes available NOW rather than having us get SCREWED waiting for ages and having our condition only worsen and have ourselves live a life far less meaningful than those privileged with hair.

Could not agree more.

[Conpecia]

The miserably embarrassing part about that research is that health ministries (such as the FDA) would do everything in their power to make a commercial treatment jump through so many hoops (clinical trials) that it basically renders the finding and excitement completely useless for the next 5 or MORE years (its never been 'within 5 years'). It really is only exciting to low norwoods who can tolerate their current hair loss status OR to future bald men who are unaware of their balding condition but will surely benefit from future treatments that are bound to be superior than that piss poor piece of shit pill known as finasteride.

I would demand the treatment becomes available NOW rather than having us get SCREWED waiting for ages and having our condition only worsen and have ourselves live a life far less meaningful than those privileged with hair.

dude, you might want to consider one day getting a system if it is this important to you. i will consider it if i reach nw4 territory or if people start regularly commenting on my hair loss.

if you legitimately believe you will live a less meaningful life because you are going bald, if it's that overwhelming and makes your life that awful, i'd get a badass, undetectable system in a heartbeat rather than stay on these forums and obsess about it. obviously it's not "the cure" but it sure as hell beats a) being a tortured nw7 and dealing with the social bullshit, and b) putting god knows what into your system with these experimentals that fail time and time again. and when the cure is finally here you can just shave your head and jump ship. seriously, consider it. it's a legitimate option that is becoming more and more common and less taboo.

check this shit out. pretty ****ing solid and i'd risk getting noticed rather than walk around like a bald bastard:

https://www.youtube.com/watch?v=yZ6WqdwHJb0

https://www.youtube.com/watch?v=oyBMGtgqtmk

https://www.youtube.com/watch?v=SEv0ZUya4jI

https://www.youtube.com/watch?v=c0-ekPdGUho

https://www.youtube.com/watch?v=pgecBxOS6CU

[hellouser]

dude, you might want to consider one day getting a system if it is this important to you. i will consider it if i reach nw4 territory or if people start regularly commenting on my hair loss.

if you legitimately believe you will live a less meaningful life because you are going bald, if it's that overwhelming and makes your life that awful, i'd get a badass, undetectable system in a heartbeat rather than stay on these forums and obsess about it. obviously it's not "the cure" but it sure as hell beats a) being a tortured nw7 and dealing with the social bullshit, and b) putting god knows what into your system with these experimentals that fail time and time again. and when the cure is finally here you can just shave your head and jump ship. seriously, consider it. it's a legitimate option that is becoming more and more common and less taboo.

check this shit out. pretty ****ing solid and i'd risk getting noticed rather than walk around like a bald bastard:

https://www.youtube.com/watch?v=yZ6WqdwHJb0

https://www.youtube.com/watch?v=oyBMGtgqtmk

https://www.youtube.com/watch?v=SEv0ZUya4jI

https://www.youtube.com/watch?v=c0-ekPdGUho

https://www.youtube.com/watch?v=pgecBxOS6CU

NEVER.

I will NOT give in to that, I won't ever accept a hair system. I want my own hair in full density. I'd rather be bald than lower myself to that fake stuff. I watched a hair system video the other day and it made me extremely depressed.

[Conpecia]

that makes zero sense from every perspective other than the cliche "it's a toupee" point of view. it's real human hair that has the exact same texture and color as your own hair. i bet you go in once a month to get your hair cut anyways. in this scenario you just replace your hair system and cut the hair that's grown. it's undetectable, literally nobody could ever know unless you tell them. you can swim, play bball, sweat, do whatever you ****ing want and that's not coming off. i would gladly do this before i walk around with a huge bald spot and a hairline behind my ears. it looks completely natural. period. it looks exactly like you are an nw0.

[locke999]

that makes zero sense from every perspective other than the cliche "it's a toupee" point of view. it's real human hair that has the exact same texture and color as your own hair. i bet you go in once a month to get your hair cut anyways. in this scenario you just replace your hair system and cut the hair that's grown. it's undetectable, literally nobody could ever know unless you tell them. you can swim, play bball, sweat, do whatever you ****ing want and that's not coming off. i would gladly do this before i walk around with a huge bald spot and a hairline behind my ears. it looks completely natural. period. it looks exactly like you are an nw0.

That is great but what happens when you find a mate and then you have to tell them that all that stuff on your head is not your hair and when you take it off, they will see your bald head. It will be a shock and a lie unless you plan on hiding it forever.

I would rather be bald (and that is something I would really rather not be).

[Thinning87]

Hey guys,

Cotsarelis has previously stated in this interview:

http://dermatologyfoundation.org/pdf/pubs/DF_Winter_2012.pdf

"The technology does not yet exist for
determining whether this pathological in-
crease in PGD 2 is responsible for inhibiting
stem cell activation in the bulge. Hair folli-
cle stem cells are finicky, and the culture
conditionsthatwouldenablethemtomain-
tain their stemness and induce growth of a
hair are unknown. Thus there is no way to
culturefunctionalhairfolliclestemcellsso
thatPGD 2 canbeaddedtoobservetheirim-
pact. When attempts are made to culture
hair follicle stem cells, they start to behave
likeinterfollicularkeratinocytes.Progenitor
cells haven’t even gotten that far—they re-
mainsteadfastlyresistanttoculture."
(sorry for bad format)
i.e. they could not add pgd2 to hair follicle stem cells as they did not act as they should outside of their natural environment.

Do you think with the recent hair follicle model developed this may now be possible?

http://www.asianscientist.com/in-the-lab/hair-follicle-model-accelerate-cure-baldness-2013/

It even says that it could be used to screen for novel drug compounds.

Could pgd2 be added its effects studied and then a GPR44 blocker added to see its effect as well? Also pge2 and other things i discussed here:http://www.baldtruthtalk.com/showthread.php?p=128172

I'm sure Follica already had planned ways to test their fgf9 research in humans. But maybe this new finding might help... There is no easy way to know

[HairlossAt15]

If PDG2 inhibited follicles showed regrowth after application of a GPR44 inhibitor then that would be very exciting. Also if pdg2 was applied and a loss of progenitor cells was found then that would be very promising as well.