Fgf9

[rdawg]

What do we know about it?

What is the harm in injecting it?(or at least potential harm)

is this a huge piece of the puzzle that we were missing? Should this be combined with PGD2?

been alot of talk about this stuff, just wanted a specific thread for it.

http://en.wikipedia.org/wiki/FGF9

http://www.uphs.upenn.edu/news/News_Releases/2013/06/cotsarelis/

[Desmond84]

There is TWO ways to approach this:

1) FGF-9 analogues: these mimic our own FGF-9. AFAIK, there are no analogues currently approved on the market.

2) FGF-9 inducers: these increase the amount of FGF-9 produced by the body! Doxycycline was one of these inducers mentioned in the study which significantly increased the levels of FGF-9!

[rdawg]

There is TWO ways to approach this:

1) FGF-9 analogues: these mimic our own FGF-9. AFAIK, there are no analogues currently approved on the market.

2) FGF-9 inducers: these increase the amount of FGF-9 produced by the body! Doxycycline was one of these inducers mentioned in the study which significantly increased the levels of FGF-9!

Im iffy on this but how would we induce more FGF-9 in our general hair area when its not there in the first place?

From what i've read we'd have to inject it(so the analogue way as you put it) but obviously that's mostly untested right?

has this stuff been tested for anything else?

[Desmond84]

I'm sure our bodies produce FGF-9 but not as much as mice! So at least in theory FGF-9 inducers should make a difference...

On the other hand, there is no such thing as a FGF-9 injection...I really don't know how Follica is planning on doing this trial without doing a safety study on FGF-9 first!

[clandestine]

There is TWO ways to approach this:

1) FGF-9 analogues: these mimic our own FGF-9. AFAIK, there are no analogues currently approved on the market.

2) FGF-9 inducers: these increase the amount of FGF-9 produced by the body! Doxycycline was one of these inducers mentioned in the study which significantly increased the levels of FGF-9!

Yet Doxycycline taken orally causes hair loss!

[rdawg]

Yet Doxycycline taken orally causes hair loss!

even with wounding?

[clandestine]

even with wounding?

In would imagine wounding wouldn't matter, concerning doxy taken orally.

Honestly, doxy causes hair loss, look it up.

[beetee133]

I thought this was interesting and although I've seen a few people post about this connection on other forums it seems like it might still be kind of under the radar:

"Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase Cdelta and Elk-1 signaling."

http://www.ncbi.nlm.nih.gov/pubmed/16982695

Whether PGE2 will induce FGF9 production is this context (i.e., the scalp and in service of the production of new hair follicles) I of course have no idea as the pathways involved are so complex and the effects of these chemicals so varied, but the connection seems at least potentially interesting and significant.

[rdawg]

In would imagine wounding wouldn't matter, concerning doxy taken orally.

Honestly, doxy causes hair loss, look it up.

I know this is a late bump, but would doxy work differently if used topically?

How else can we get FGF-9 stimulators/producers guys? what is Follicle planning on using to test this theory?