List of Future Treatments Being Trialled Part 3!(June 2013 edition)
Hell everyone, I started doing this in June 2012 roughly a year ago! Just to keep real track of how we were progressing in terms of hairloss products and just how much movement is being made over the course of 6 months. I choose 6 months or so because it's a slow industry that doesnt exactly do weekly updates!
Please correct me on any mistakes as some of these products are fairly complicated, but I'd figure i'll try and put them all in one thread
here are the original threads!- Part 1(June 2012): http://www.baldtruthtalk.com/showthread.php?t=8971
Part 2(December 2012):
http://www.baldtruthtalk.com/showthread.php?t=10575
Current FDA Approved Treatments:
1. Minoxidil- Approved in the late 1980's, topical solution for hairloss.
What to expect from it- it should at least slow your loss a bit, a lucky few may gain a bit as well, do not expect major growth or maintanence however. very few if any sides occur however. At best it usually described as capable of giving 10% hair regrowth.
2. Finasteride/Propecia/Proscar- Proscar was approved in 1992, propecia(specifically for hairloss) was approved in 1997. A pill to be taken daily.
What it does- works by acting as a potent and specific, competitive inhibitor of one of the two subtypes of 5α-reductase, specifically the type II isoenzyme. In other words, it binds to the enzyme and prevents endogenous substrates such as testosterone from being metabolized. 5α-reductase type I and type II are responsible for approximately one-third and two-thirds of systemic DHT production, respectively. In easier to understand words, it lowers your DHT systematically(roughly 60%) to help maintain your hair.
What to expect from it- Currently the best product that has been approved, at the least it should maintain most of your hair, on average, people keep roughly the same hair for years, a small percentage(around 30% i believe) will see moderate regrowth. A lucky few may even go up a norwood(dont expect this though).
-Expect some shedding, also the potential for side effects is there, such as sexual sides, so get to know the product thoroughly before taking it.
Nizoral/Keto: Not approved specifically for hairloss but constantly used in conjunction with these two products, it has been shown to cause some kind of benefit to hairloss by many.
Using these three combined are often referred to as the big 3 on these forums.
List of Treatments being trialed as of June 15th, 2013:
1.Histogen- Injection based treatment, probably the most hyped up treatment coming out in the future.
Phase IIa is complete, final results here:
http://www.histogen.com/downloads/ii..._hsc_final.pdf
Expected release: still On track for late 2015-early 2016 asia, 2016-2017 North America
My Pov: The final results, while somewhat dissapointing, were still nothing to balk at, growth was experienced by almost everyone to varying extents, and it should also be noted that this was only the safety trial!
However there is a concern for how much of the stuff they can inject at one time, that may hinder what bigger gains they may hope to acheive in IIb.
Next step: Phase IIb, hopefully by the end of 2013, they should be injecting a wider area or at least raising the dose somewhat, hold off judgement until the end of this phase.
2.Bitmatoprost(Allergan): Essentially an alternative to minoxidil, this topical product seems to be more powerful than minoxidil. Phase II was completed, however they believe they can get higher results by upping the dose and therefore will go back to phase II for another year.
Expected release: 2016-2017 NA due to phase II being restarted.
My Pov: An interesting alternative, but definitely far away! The next results will be interesting because the product definitely works, however the potential side affects such as pigmentation are worrisome.
Next step: Phase IIb, should begin within a few months.
Side Note- This product IS available to the public for eye-lash extension, however, this is at a much lower dosage than what is being tested/getting results in the trials for hair so dont assume you'll get the same results using that stuff. Some have used it off-label and have had noticeable gains, but nothing life changing.
Examples of off-label 0.03% use: http://www.*****************/interact...lergan-Lumigan
http://www.bernsteinmedical.com/rese...ss-medication/
3.Replicel- This product just came back to life! Recently gained funding in May to continue work! Also an injection product, with dissapointing early results, but there may be a bright light at the end of this tunnel if they just got that funding!
http://www.replicel.com/replicel-and...ology-license/
Expected release- probably 2017-2018 at current pace.
my POV: Not sure how to feel on this, the early results were dissapointing, but i'd still give them another phase before tossing this one out the window.
Next Step: Phase IIb, hopefully the results get better!
4. Aderans- Also an injection based solution that's been trialled for years now. They call it "Follicle neogenesis" Currently heading to Phase III from what I understand.
Video of latest results(nov 2012) here: http://https://www.youtube.com/watch?v=l_JHbtXJ0a8
Expected release: Potentially 2015-2016, but struggling to get big results.
My Pov: Latest results were very dissapointing, it seems to maintain to some degree, but the gains were not noticeable, HOWEVER that doesnt mean it doesnt work, it just may be better used as a complimentary product with say histogen, wouldnt get my hopes too high up though.
June2013 update: These guys have disappeared, oddly enough no news has come since I last wrote about them!
Next step: From what I understand, Phase III.
5. OC000459- Inhibits PGD2, a theory thats popped up alot recently which apparently has alot to do with hairloss. Could only be a piece of the puzzle though. Currently being trialled for Asthma: http://www.news-medical.net/news/200...or-asthma.aspx
Expected release- In Phase IIb for asthma, for hairloss could be quickly put to Phase II so 2015-2016 is possible.
my POV: The theory sounds great, and more products need to be tested.
Side Note: A: Many companies are also testing PGD2 inhibitors, but this is usually in pill form, a solution may come through topical form only for baldness, pill form may do nothing for it.
Notable recent Theories:
1. PGD2 Inhibition- other than OC000459, this theory has gained alot of popularity recently:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/
Some see it as a piece to the puzzle and at the very least a near future alternative to Fin as it is more direct to the problem. It is believed that something which causes more PGE2(Minoxidil is a weak inducer for this) in the scalp should be taken alongside it. It's also believed this will essentially only stop the loss, as the follicles that had shrunk may not come back to life.
2. FGF9: http://medicalxpress.com/news/2013-0...ring-hair.html
The theory here, is that some kind of wounding process, alongside an injection of FGF9 may be necessary in order to regrow our hair. This was tested on mice and brought great results, it's a very new theory but hopefully something comes out of it! This somewhat builds on the PGD2 theory.
3. BNP-32:
http://www.google.com/patents/US20120238498
I am unfamiliar with this product but a patent came out a few months ago stating this peptide could cause terminal hair growth! Some people have gotten their hands on the stuff but it is quite early to say if it does anything.
Other notable products:
i. CB-03-01- potential alternative to Fin, about to/just started clinical trials. Constantly mentioned however the vehicle to get through the scalp still needs to be figured out! Still, this is a very interesting product that should be kept in mind. It's also fairly easy to get a hold of.
ii. Equol- Potential alternative to fin, not being trialled
iii. RU- Potential alternative to fin, not being trialled, constant threads made about it, usually seen as a decent alternative.
iv. TB4- already released, havent seen amazing results but check it out for yourself.
Again correct me if I missed anything big or made any glaring mistakes, i'll make another update around christmas!
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