Cotsarelis/Garza Genetic analysis

[KO1]

They've grown hair follicles in wounding tests without any treatment on humans in 2007. It's not a big deal to get a few hairs, but getting cosmetically significant results.

So far we know
Wnt - critical signal
FGF - agonist of this pathway
PGD2 - antagonist of this pathway

Thus far it seems that their goal is to use the core treatment of Wnt (lithium) and strengthen it with other chemicals that upregulate or remove inhibition of this process. Whether the results are cosmetically significant is unknown. They also need to figure out at which point in time which factors to upregulate/downregulate....

The wound has to be deep enough to remove the epidermis, and a reasonably large area, so that it doesn't close on itself, so no pinpricks. In their clinical trials they did two depths 1) Remove epidermis or 2) Cut down to subcutaneous fat.

If people want to try this they can, all the treatments are available. Wnt is mimicked by lithium, PGD2 is inhibited by Ramatroban (on my desk), FGF appears to be elevated by doxycycline....and wounding can be done by sandpaper. Don't try to use it on your head, try it on an arm or a leg. You can also add immunosuppressant cream (Tacrolimus) or topical estrogen if you'd like.

[Thinning87]

ehm thanks for the explanation but you can try it first

[clandestine]

Alright, listen.

What is this business about Doxycycline upregulating FHF or whatever? I swear they tried to give me Doxy for acne as an anti-bacterial.

I did research, and of causes hair loss. I literally have the pills, never taken for this reason, right here.



Look it up. Doxy causes hair loss. I don't understand.

[HairlossAt15]

More on deactivated bulge/stem cells:
Cotsarelis Interview:
" After a variety of confir-
matory tests,they were able to conclude that
“loss of this CD200hiITGA6hi population in
AGA represents a loss of activated bulge
cells.” These were not the quiescent stem
cells,but the progenitor cells responsible for
the immediate growth of new hair."

So these cells are needed for activation of the bulge(stem cells). Transfer of these cells is mentioned in his patent, as well as analogues of these cells. Perhaps pdg2 targets these cells as pdg2 is found at high levels at the secondary germ which i believe is were the CD200hiITGA6hiare located.

Now I am beginning to understand why Cotsarelis focuses so much on pdg2 when there were other genes involved as well. Either way more reason to be excited.

[Pentarou]

Alright, listen.

What is this business about Doxycycline upregulating FHF or whatever? I swear they tried to give me Doxy for acne as an anti-bacterial.

I did research, and of causes hair loss. I literally have the pills, never taken for this reason, right here.



Look it up. Doxy causes hair loss. I don't understand.

A drug applied topically may have completely different effects to the same drug being rconsumed orally.

[KO1]

Lithium causes hair loss , but Follica used it in P2 trials. Point is, let's not generalize.

[KO1]

ehm thanks for the explanation but you can try it first

I would, I'm just tired and lazy at this point.

[ar50]

Hey guys.

I wondered if one of us know how to contact dr. Cotsarelis, or his colleagues?
Maybe if we can get a hold and this guy ans his colleagus, we could get more info.

Greetings

AR

[HairlossAt15]

Hey guys.

I wondered if one of us know how to contact dr. Cotsarelis, or his colleagues?
Maybe if we can get a hold and this guy ans his colleagus, we could get more info.

Greetings

AR

Here is his email: cotsarel@mail.med.upenn.edu

He has replied to me before but no guarantees.

[ar50]

Here is his email: cotsarel@mail.med.upenn.edu

He has replied to me before but no guarantees.

Thanks bro!