Dr. Cotsarelis New Discovery that may finally cure Baldness (June 3rd, 2013)

[imom]

I think some of you are jumping the gun here.

If new follicles are created, they will most likely form in the same way that their neighbouring follicles were formed, which leaves them just as vulnerable to all the same hair loss problems.

We don't need more follicles, we need to get existing follicles working for good.

[UK_]

I think some of you are jumping the gun here.

If new follicles are created, they will most likely form in the same way that their neighbouring follicles were formed, which leaves them just as vulnerable to all the same hair loss problems.

We don't need more follicles, we need to get existing follicles working for good.

In 2011, Follica released research that showed the bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. Due to this problem, the hair follicles are producing microscopic hairs beneath the surface of the skin, their research therefore is aimed at bringing to the market a solution that will enable said stem cells/hair follicles to 'reactive' by producing the necessary CD-200 and CD34-positive hair follicle progenitor cells.

By researching the cascade of events that takes place during the wound healing process, they may have just done so.

I think it will have to be a case of mild to medium scalp pertubation and timing an injection of FGF9 appropriately to nudge the immune response into the creation of a new hair follicle, this is true regenerative medicine here, instead of the body going down the route of creating a scar, we're finding the key compounds from nature to induce regeneration of organs (hair follicles).

It's exciting yes, and we have to all understand something, that if researchers can't figure out ways to regenerate hair follicles, then they're going to have an equal amount of difficulty in regenerating larger more complex organs. Do you believe that will happen? I dont, especially when I look at the work coming out of Wake Forest (WFIRM); It's more a question of time now.

[Thinning87]

I think some of you are jumping the gun here.

If new follicles are created, they will most likely form in the same way that their neighbouring follicles were formed, which leaves them just as vulnerable to all the same hair loss problems.

We don't need more follicles, we need to get existing follicles working for good.

Another genius schooling UCSF and the UPenn med schools.

Thank you now they will realize they are all idiots!

[Desmond84]

Guys,

If you read the threads from 2007-2010 regarding Follica, you see a lot of talking about being cured by 2010-2012! Dr. Cotsarelis himself was found quoting that "IF everything pans out...we will have this available by 2010!" Back in 2007 though, all they had were mice data.

The problem is Proof of Concept studies start off with mouse and then move onto Human tissue...

So far, all of these recent breakthroughs have been in rats and such theories have not been tested on actual human grafts!

So, we shouldn't jump the gun and start yelling out "cure", when Dr Cotsarelis has NOT shown any increase in number of hair follicles on a HUMAN skin graft! For some evolutionary reasons, mice are meant to be incredibly hairy and triggering hair growth in them is far easier than humans!

Let's keep a watchful eye on Follica...as they may be onto something! But until we have HUMAN data be critical to all media releases.

[burtandernie]

Its a possible thing in the future that could turn out to be something, but I mean we have no concrete studies or results in humans yet. Until that happens its still theorycrafting so hopefully they have some results already, but until we see them who knows how they spin this. Growing 100 new hairs is new hair growth, but its not going to mean a whole lot for men that are bald so it also has to compound results to add up to some significant amount of hair.

[Thinning87]

Guys,

If you read the threads from 2007-2010 regarding Follica, you see a lot of talking about being cured by 2010-2012! Dr. Cotsarelis himself was found quoting that "IF everything pans out...we will have this available by 2010!" Back in 2007 though, all they had were mice data.

The problem is Proof of Concept studies start off with mouse and then move onto Human tissue...

So far, all of these recent breakthroughs have been in rats and such theories have not been tested on actual human grafts!

So, we shouldn't jump the gun and start yelling out "cure", when Dr Cotsarelis has NOT shown any increase in number of hair follicles on a HUMAN skin graft! For some evolutionary reasons, mice are meant to be incredibly hairy and triggering hair growth in them is far easier than humans!

Let's keep a watchful eye on Follica...as they may be onto something! But until we have HUMAN data be critical to all media releases.

That is true but keep in mind they are not just doing tests on mice, they are comparing between us and mice and looking at what can work for us. This is the same type of thing Histogen is doing so there is no way these growth factors do not work. It's just a matter of figuring out what can be used in the best way. I definitely have a lot of faith in them and I don't understand why wouldn't you after having been really excited about things as blurry as team tokyo

[hairandthere]

Guys,

So far, all of these recent breakthroughs have been in rats and such theories have not been tested on actual human grafts!

So, we shouldn't jump the gun and start yelling out "cure", when Dr Cotsarelis has NOT shown any increase in number of hair follicles on a HUMAN skin graft! For some evolutionary reasons, mice are meant to be incredibly hairy and triggering hair growth in them is far easier than humans!

Let's keep a watchful eye on Follica...as they may be onto something! But until we have HUMAN data be critical to all media releases.

First post here. Hi Desmond. I'm definitely not here to antagonize. I appreciate very much the information that you bring to light on this forum.

Are you saying that the media releases and statements made by one of the Follica co-founders are fabricated? Or did you just miss the information that they have grown a new hair follicle in a human for the first time in history?

http://www.xconomy.com/boston/2013/0...dness-therapy/

Follica said in its statement that it has already done preclinical tests that combine devices it has created to disrupt the skin with several unspecified “known and novel drugs.” It also claims to have run “a series” of human clinical trials, including a mid-stage study that has caused new hair follicles to be produced in humans. Unfortunately for our rabid readers, however, Olle and Follica aren’t offering many details from these studies, other than to indicate that the platform is proving to work so far and that the research has paved the way for the company’s next step: to try a specific device configuration with a specific, well-known and studied drug (meaning it wouldn’t have to be as extensively tested as a new chemical) in a group of human patients.

[Pentarou]

The Fgf9 aspect was patented in 2010.

http://www.freepatentsonline.com/WO2010056759A1.html

[Desmond84]

First post here. Hi Desmond. I'm definitely not here to antagonize. I appreciate very much the information that you bring to light on this forum.

Are you saying that the media releases and statements made by one of the Follica co-founders are fabricated? Or did you just miss the information that they have grown a new hair follicle in a human for the first time in history?

http://www.xconomy.com/boston/2013/0...dness-therapy/

Hey brother

Welcome to BTT...so this study that was published was conducted in humans! That is definitely worth a read!!!

Guys is anyone able to access this article and either post it on this site or email it to me or anyone you like...let's see if it is really as ground breaking as everyone thinks it is...here's the link:

http://www.nature.com/nm/journal/vao...l/nm.3181.html

Thanks in advance btw

[UK_]

Hey brother

Welcome to BTT...so this study that was published was conducted in humans! That is definitely worth a read!!!

Guys is anyone able to access this article and either post it on this site or email it to me or anyone you like...let's see if it is really as ground breaking as everyone thinks it is...here's the link:

http://www.nature.com/nm/journal/vao...l/nm.3181.html

Thanks in advance btw

That article you linked us to isnt what they're talking about in the following segment:

Follica has conducted preclinical testing of proprietary device configurations for skin disruption in combination with a number of known and novel drugs. The company has run a series of human clinical trials, including a Phase IIa trial, which have demonstrated follicular neogenesis in humans for the first time. These trials pave the way for the development of a breakthrough combination of a device to produce targeted skin perturbation coupled with a well-studied drug compound.

Follica have run a number of human trials based upon the theoretical work associated with mouse studies and FGF9 including a human preclinical trial, that particular work is not related to the link you posted. Follica are immensely secretive, it's very difficult to know exactly what they're up to, however I have never seen them come out and state in a news release they have shown human hair follicle regeneration, that is important to note.