Dr. Cotsarelis New Discovery that may finally cure Baldness (June 3rd, 2013)
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I think some of you are jumping the gun here.
If new follicles are created, they will most likely form in the same way that their neighbouring follicles were formed, which leaves them just as vulnerable to all the same hair loss problems.
We don't need more follicles, we need to get existing follicles working for good.Comment
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I think some of you are jumping the gun here.
If new follicles are created, they will most likely form in the same way that their neighbouring follicles were formed, which leaves them just as vulnerable to all the same hair loss problems.
We don't need more follicles, we need to get existing follicles working for good.
By researching the cascade of events that takes place during the wound healing process, they may have just done so.
I think it will have to be a case of mild to medium scalp pertubation and timing an injection of FGF9 appropriately to nudge the immune response into the creation of a new hair follicle, this is true regenerative medicine here, instead of the body going down the route of creating a scar, we're finding the key compounds from nature to induce regeneration of organs (hair follicles).
It's exciting yes, and we have to all understand something, that if researchers can't figure out ways to regenerate hair follicles, then they're going to have an equal amount of difficulty in regenerating larger more complex organs. Do you believe that will happen? I dont, especially when I look at the work coming out of Wake Forest (WFIRM); It's more a question of time now.Comment
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I think some of you are jumping the gun here.
If new follicles are created, they will most likely form in the same way that their neighbouring follicles were formed, which leaves them just as vulnerable to all the same hair loss problems.
We don't need more follicles, we need to get existing follicles working for good.
Thank you now they will realize they are all idiots!Comment
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Guys,
If you read the threads from 2007-2010 regarding Follica, you see a lot of talking about being cured by 2010-2012! Dr. Cotsarelis himself was found quoting that "IF everything pans out...we will have this available by 2010!" Back in 2007 though, all they had were mice data.
The problem is Proof of Concept studies start off with mouse and then move onto Human tissue...
So far, all of these recent breakthroughs have been in rats and such theories have not been tested on actual human grafts!
So, we shouldn't jump the gun and start yelling out "cure", when Dr Cotsarelis has NOT shown any increase in number of hair follicles on a HUMAN skin graft! For some evolutionary reasons, mice are meant to be incredibly hairy and triggering hair growth in them is far easier than humans!
Let's keep a watchful eye on Follica...as they may be onto something! But until we have HUMAN data be critical to all media releases.Comment
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Its a possible thing in the future that could turn out to be something, but I mean we have no concrete studies or results in humans yet. Until that happens its still theorycrafting so hopefully they have some results already, but until we see them who knows how they spin this. Growing 100 new hairs is new hair growth, but its not going to mean a whole lot for men that are bald so it also has to compound results to add up to some significant amount of hair.Comment
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Guys,
If you read the threads from 2007-2010 regarding Follica, you see a lot of talking about being cured by 2010-2012! Dr. Cotsarelis himself was found quoting that "IF everything pans out...we will have this available by 2010!" Back in 2007 though, all they had were mice data.
The problem is Proof of Concept studies start off with mouse and then move onto Human tissue...
So far, all of these recent breakthroughs have been in rats and such theories have not been tested on actual human grafts!
So, we shouldn't jump the gun and start yelling out "cure", when Dr Cotsarelis has NOT shown any increase in number of hair follicles on a HUMAN skin graft! For some evolutionary reasons, mice are meant to be incredibly hairy and triggering hair growth in them is far easier than humans!
Let's keep a watchful eye on Follica...as they may be onto something! But until we have HUMAN data be critical to all media releases.Comment
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Guys,
So far, all of these recent breakthroughs have been in rats and such theories have not been tested on actual human grafts!
So, we shouldn't jump the gun and start yelling out "cure", when Dr Cotsarelis has NOT shown any increase in number of hair follicles on a HUMAN skin graft! For some evolutionary reasons, mice are meant to be incredibly hairy and triggering hair growth in them is far easier than humans!
Let's keep a watchful eye on Follica...as they may be onto something! But until we have HUMAN data be critical to all media releases.
Are you saying that the media releases and statements made by one of the Follica co-founders are fabricated? Or did you just miss the information that they have grown a new hair follicle in a human for the first time in history?
http://www.xconomy.com/boston/2013/06/03/hair-raising-follica-study-could-point-to-baldness-therapy/Creativity can be learned, and everyone can develop good copy. One Led Inc's Lead Copywriter Brianne Dromey showed us a complete framework on how to ace the process and write unique headlines.
Follica said in its statement that it has already done preclinical tests that combine devices it has created to disrupt the skin with several unspecified “known and novel drugs.” It also claims to have run “a series” of human clinical trials, including a mid-stage study that has caused new hair follicles to be produced in humans. Unfortunately for our rabid readers, however, Olle and Follica aren’t offering many details from these studies, other than to indicate that the platform is proving to work so far and that the research has paved the way for the company’s next step: to try a specific device configuration with a specific, well-known and studied drug (meaning it wouldn’t have to be as extensively tested as a new chemical) in a group of human patients.Comment
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Guys,
If you read the threads from 2007-2010 regarding Follica, you see a lot of talking about being cured by 2010-2012! Dr. Cotsarelis himself was found quoting that "IF everything pans out...we will have this available by 2010!" Back in 2007 though, all they had were mice data.
The problem is Proof of Concept studies start off with mouse and then move onto Human tissue...
So far, all of these recent breakthroughs have been in rats and such theories have not been tested on actual human grafts!
So, we shouldn't jump the gun and start yelling out "cure", when Dr Cotsarelis has NOT shown any increase in number of hair follicles on a HUMAN skin graft! For some evolutionary reasons, mice are meant to be incredibly hairy and triggering hair growth in them is far easier than humans!
Let's keep a watchful eye on Follica...as they may be onto something! But until we have HUMAN data be critical to all media releases.
Follica has conducted preclinical testing of proprietary device configurations for skin disruption in combination with a number of known and novel drugs. The company has run a series of human clinical trials, including a Phase IIa trial, which have demonstrated follicular neogenesis in humans for the first time. These trials pave the way for the development of a breakthrough combination of a device to produce targeted skin perturbation coupled with a well-studied drug compound.
http://www.marketwatch.com/story/new...ess-2013-06-03
I have to also add that this is very important news, they have updated their 'news' section on the Follica website, even when they made the PGD2 discovery, they did not add it to the 'news' section of the website.
Maybe this will make Aderans/Replicel and Histogen speed up, because Follica seem to be racing ahead to Phase III.Comment
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As far as FgF-9 goes i dont think they have actually tested this on humans. The phase trials they are talking about are their old "wounding" + lithium trials.
If FgF-9 is Key would they need to start trials again or could they bounce off their earlier "wounding" + lithium trials?Comment
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As far as FgF-9 goes i dont think they have actually tested this on humans. The phase trials they are talking about are their old "wounding" + lithium trials.
If FgF-9 is Key would they need to start trials again or could they bounce off their earlier "wounding" + lithium trials?Comment
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After doing some research on FgF-9 looks like this was known in 2010.
http://www.hair site.com/hair-loss/board_entry-id-68219-page-0-order-time-category-0.html
(just remove the space in-between hair and site)
The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (H
his FgF-9 patent filed in 2009Comment
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Not from what i read.
After doing some research on FgF-9 looks like this was known in 2010.
http://www.hair site.com/hair-loss/board_entry-id-68219-page-0-order-time-category-0.html
(just remove the space in-between hair and site)
The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (H
his FgF-9 patent filed in 2009
I dont see how you can say they havent been working with FGF9 in humans:
The authors first showed that Fgf9 is up-regulated in the dermis immediately before new hair follicle structures start to appear. Reducing Fgf9 expression decreased hair follicle formation, while overexpressing Fgf9 led to two to three-fold increase in the number of new hair follicles. The study supports the notion that disruption of the skin produces a window of opportunity during which the cells in the regenerating epidermis can be pushed towards becoming a hair follicle, and highlights the potential for using Fgf9 therapeutically to boost the formation of new hair follicles during this window.Follica has conducted preclinical testing of proprietary device configurations for skin disruption in combination with a number of known and novel drugs (lithium?). The company has run a series of human clinical trials, including a Phase IIa trial, which have demonstrated follicular neogenesis in humans for the first time. These trials pave the way for the development of a breakthrough combination of a device to produce targeted skin perturbation coupled with a well-studied drug compound (???).Comment
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