Histogen's FINAL Phase I/IIa Results (2013)

[StinkySmurf]

Thanks Des!

I always thought Histogen's HSC was the most like Botox, and I don't think that changed with this news.

The longevity is less than I hoped for, but I wonder what is the toxicity of a Botox injection by comparison?

How many injections of each can you get at one time?

[Arashi]

This is really disappointing

[garethbale]

Why doesn't someone contact Histogen to quiz them about the results and implications for further trials. Can these be improved with a new trial?

They seem to think the results were exciting (yes I'm aware they are bound to say that)

[534623]

Hey guys,

Histogen has finally published the results of their 12 month Phase I/IIa results. Here's the link:

http://www.histogen.com/downloads/ii..._hsc_final.pdf

Should I analyze subject's S2011 48-weeks result ...


... as I did it with the other subjects?

http://www.baldtruthtalk.com/showthread.php?t=10051

In advance: I can only see a completely normal circulating (anagen-catagen-telogen) test area.
There is absolutely nothing unusual to see.

[iH8d0ugh]

I can't see any difference between the baseline and 48 week pictures

[UK_]

Same ere lol.

WAIT A MINUTE!!!

...oh no thats just a shedded hair on my screen.

[Thinning87]

Hey guys,

Histogen has finally published the results of their 12 month Phase I/IIa results. Here's the link:

http://www.histogen.com/downloads/ii..._hsc_final.pdf

There's a lot of information which is provided and requires extensive discussion.

1) Duration of Efficacy: Although the patients remained above baseline at the 48 week follow-up, the effects started to wear off by that point: % Change from baseline: 19% (Week 12) compared to 12% (Week 36). This means that patients will need booster shots at least ONCE A YEAR.

Also, isn't it odd how they haven't provided data on % change from baseline for the 48th week even though they did measure it! (Food for thought)

2) Total Hair count in the Temporal Region (temples) increased only by 2.5% at the 48 week follow-up.

3) Therapeutic Window: They found a direct relationship between dose and possible toxicity (Haemoglobin count). Therefore, only so many mL of HSC can be injected at a given session. Otherwise, your Haemoglobin levels may drop and lead to anaemia and other related conditions. This is very important, as it means you cannot get Histogen injected all over your scalp in a single session... HSC will be simply used in your most problematic areas to give you that extra boost in hair density.

4) Safety: using only 8 shots of HSC lead to no abnormal parameters in trial subjects. Furthermore, all reported side effects were mild and transient, which is a big plus.

1 and 2) The benefits decay overtime, we all knew that....

3 and 4) We don't know yet how often and how much can be injected. Assuming your deduction of an upper limit is correct, I wouldn't conclude the maximum level than can be injected is insufficient for significant growth and results. I think this is where phase 2B comes in, but we don't know that this is a major problem. They could figure out strategies to inject larger amounts in such ways not to increase significantly the risk of dangerous side effects.