Link to Topical Finasteride

[clandestine]

Better than a lack of options..

[zephyrprime]

I made my own topical dutasteride solution by crushing some pills into a premade rogaine solution. It had no effect. However, finasteride has a lower molecular weight than dutasteride (372.55 vs 528.53 g/mol) so maybe it would work better .

[HARIRI]

Topical Finasteride is very interesting indeed, however I still need to see it to be sold officially in pharmacies and drugstores. By then I will give it a try as oral Finasteride gave me great results but a lot of sexual sides. I hope the topical formula will solve the libidio issue somehow.

[Arashi]

This was presented at the 7th world congress of hair research:


P040
Pharmacodynamic of P-3074 (finasteride 0.25% topical solution) in subjects with
androgenetic alopecia

M Caserini1, R Palmieri1, M Radicioni2 and E Terragni2 1Polichem S.A., Lugano, Switzerland and
2Cross Research S.A., Arzo, Switzerland

A new proprietary topical formulation, P-3074, containing finasteride 0.25% as active ingredient
and hydroxypropyl-chitosan (HPCH) as film-forming agent, was developed for androgenetic
alopecia. The present study was aimed at investigating the pharmacodynamic profile of
finasteride in terms of dihydrotestosterone (DHT) concentrations in the scalp and in serum after
multiple topical application of P-3074 or oral finasteride intake in subjects with androgenetic
alopecia. Eighteen healthy men were randomly allocated to P-3074 or oral treatment after
providing written informed consent. Twelve volunteers applied P-3074 topical solution for 7
days: six subjects once daily (o.d.) in the morning and the others twice daily (b.i.d.) in the morning
and in the evening. The third group of six volunteers was administered 1mg oral finasteride once
daily in the morning for 1 week. Scalp (vertex) biopsies were collected at baseline and 6 hours
after last dose administration, while serum samples were collected at baseline, before last
administration, and 6 and 12 hours after the last multiple dose.

A marked decrease in scalp DHT levels was observed:

by 47.22% with P-3074 b.i.d., from 1.91 (±0.54) to 1.01 ng ml1 (±0.39),
by 71.20% with P-3074 o.d., from 1.52 (±0.41) to 0.44 ng ml1 (±0.0, and
by 51.11% with the oral formulation, from 1.39 (±0.25) to 0.68 ng ml1 (±0.34).

Serum DHT was reduced by
69.3–74.0% with P-3074 b.i.d., 67.6–80.4% with P-3074 o.d., and
69.7–76.1% with the oral formulation.

These results showed a similar inhibition of serum DHT after 1 week of finasteride
administration with the three dose regimens and were consistent with the results obtained in a
previous P-3074 PK study. These findings show that DHT concentration in the scalp, after 7-day
treatment course of P-3074 o.d., was more reduced (about 40%) than after 1mg oral finasteride
administration for the same treatment period

[Pentarou]

Topical Finasteride is very interesting indeed, however I still need to see it to be sold officially in pharmacies and drugstores.

Same. I'd jump at the chance to switch to topical fin, for the additional effect on scalp DHT, but I'm not willing to try the DIY approach.

[Arashi]

Here you can buy HPCH:

http://vitivia.com/ecoformula.php

And here is a patent that contains info on how to mix it up yourself: http://www.google.com/patents/EP2153836A1?cl=en

[Arashi]

but I'm not willing to try the DIY approach.

yeah me neither, I'd rather wait 2 years till everything has been well tested and FDA approved. But for the people who do want to experiment, the above might be useful.

[Ginkosama]

I just don't get it, lack of oxygen in the scalp is one of the causes of MPB. Wearing a film on the scalp for the whole day isn't gonna make things worse ?

[TO YOUNG TO RETIRE]

the clinic cant send to europe the topical finasteride. just received an email

[doke]

i already just started using topical minoxidil+finas and its made by a company got one bottle for under £7 uk which is not bad and its in a lipid formula