Bulge Cells!!!!

[hellouser]

Sorry but I think Iron_Man is right here - if you look into the work of Jerry Cooley and plucked hair follicles the dermal papilla only respond well when they are transplanted into areas of thinning hair and not slick bald regions. This is (according to Cooley) because the stem cells in thinning regions are still actively sending out some 'growth' signals to the DP, when in slick bald regions there are no 'masters' so to speak or they have become entirely deactivated.


The stem cells are key to it all, I personally believe that Costeralis was right in that slick bald regions do have deactivated stem cells (you cant really refute those biopsies he took) however I do still believe in the theory of a point of no return after a very long time after going bald.

This is an interesting point when looking at the results of peptides, specifically BNP-32 with the small study. If you look at the results the patients got, they reversed hair loss but UP to a point. Which leads me to believe that early users of BNP-32 can benefit GREATLY from peptides (assuming BNP-32 will work for others as it did in the study).

Now... I wonder how BNP-32 affects the follicle and why it worked so damn well in the study.

[Boldy]

Sorry but I think Iron_Man is right here - if you look into the work of Jerry Cooley and plucked hair follicles the dermal papilla only respond well when they are transplanted into areas of thinning hair and not slick bald regions. This is (according to Cooley) because the stem cells in thinning regions are still actively sending out some 'growth' signals to the DP, when in slick bald regions there are no 'masters' so to speak or they have become entirely deactivated.


The stem cells are key to it all, I personally believe that Costeralis was right in that slick bald regions do have deactivated stem cells (you cant really refute those biopsies he took) however I do still believe in the theory of a point of no return after a very long time after going bald.

Cots work showed bald scalp retain as much stam cells as non balding scalp!, but it missed progenitor cells. (cd43,cd200). if you look to his next pgd2 study, you will see why this is.

regarding the dermal papilla, it needs Epithelial cells, to form a new hair follicle, or to reactivate the old.

the problem with aga scalp is that its genetic that the DP cells have over exprsion of Androgen receptors, (the DP is the master control of the hair folicle), and there starts all the drama. for more info check my other topics on HLH.


@ironman your previous post proofs yet again what kind of person you are., I don't see why you are so negative on this one, it has nothing to do with dr Gho .

the inductive properties of dp's after culture (trichonic) are solved.

"
cell culture
system involving three-dimensional matrices, perhaps
embedded with appropriate growth factors, to allow both
dermal and epidermal cells to differentiate towards a
normal hair follicle.

"

here are some studies for the interested. they all show DP is the main control of the hair filicle. But DS cells retain the same abilities. they can regenerate a whole new DP in vivo. also Bulge cells are trichonic and are able to reproduce a new hF.

http://www.hairlosshelp.com/forums/messageview.cfm?catid=7&threadid=103913

now ontopic,

nice study of the Brg1 signal in Bulge. It makes sense, but is definitely temporary, as long the Dermal papilla is Androgen sensitive.

http://www.sciencedirect.com/science/article/pii/S153458071300186X

[youngin]

Finally a man that makes some damn sense!!!

[534623]

(the DP is the master control of the hair folicle)

pffffft...

Can you explain me ...

http://www.ncbi.nlm.nih.gov/pubmed/7728481

... what exactly regenerated "the master control" again in this study, in case, if you simply remove the "master control" from the follicle??

Let me guess: "The master of the master control"??

[Boldy]

pffffft...

Can you explain me ...

http://www.ncbi.nlm.nih.gov/pubmed/7728481

... what exactly regenerated "the master control" again in this study, in case, if you simply remove the "master control" from the follicle??

Let me guess: "The master of the master control"??

ofcourse, like said before, the HF (that retains Bulge, SKP cells
dermal sheeth cells) can regenerate a total new Dermal papilla to continuew growing. The dermal sheeth and dermal papilla both showed to have almost same properties, and they both can regenerate eachother and the exchange during each phase. Explained very well in the studies in my earlier post.


Im not sure what you are trying to do. In my eyes you are A Toll. which is very unfortunate, for the quality of this forum, and the time people spend on you.


http://en.wikipedia.org/wiki/Troll_(Internet)

[534623]

ofcourse, like said before, the HF (that retains Bulge, SKP cells
dermal sheeth cells) can regenerate a total new Dermal papilla to continuew growing. The dermal sheeth and dermal papilla both showed to have almost same properties, and they both can regenerate eachother and the exchange during each phase. Explained very well in the studies in my earlier post.

No, that's NOT what you said before. Here is what you said BEFORE ...

(the DP is the master control of the hair folicle)

They "both can regenerate each other"?
hmmm, perhaps in mice and rats, but one thing is absolutlely certain ...

"...our finding endorses the assumption that stem cells are located in the bulge area of the hair follicle, as we did not find them in or near the dermal papilla."
Source

... the human DP can't have "almost the same properties" as there are no STEM CELLS in or near the dermal papilla. And that's also the reason why the DP doesn't have the power to control something.

[Boldy]

You seem to have trouble reading as well Troll

the Dermal sheeth cells, and SKps Can regenerate dermal papilla. its in my both 2 posts.

Post 1:

But DS (dermal sheeth)cells retain the same abilities. they can regenerate a whole new DP in vivo. also Bulge cells are trichonic and are able to reproduce a new hF.

Post2:

ofcourse, like said before, the HF (that retains Bulge, SKP cells
dermal sheeth cells) can regenerate a total new Dermal papilla to continuew growing. The dermal sheeth and dermal papilla both showed to have almost same properties, and they both can regenerate eachother and the exchange during each phase. Explained very well in the studies in my earlier post.

I will not spend more time in your troll actions.. Total waste of time.

You are the only person on this forum, that makes this forum unattractive and so damn negative.
Congratulations for destroying this forum.

http://en.wikipedia.org/wiki/Troll_(Internet)

[youngin]

... the human DP can't have "almost the same properties" as there are no STEM CELLS in or near the dermal papilla. And that's also the reason why the DP doesn't have the power to control something.

Yes there are. They are referred to as matrix stem cells:

http://www.ncbi.nlm.nih.gov/pubmed/16107474

Challenging the prevailing hypothesis, we found that the matrix contains restricted self-renewing stem cells for each inner structure. These cells are located around the dermal papilla forming a germinative layer

http://jcs.biologists.org/content/124/8/1179.full.pdf

The DP then instructs the surrounding epithelial cells, now called matrix cells, to proliferate, move upward and differentiate into the multiple layers of the outgrowing hair shaft

Surprisingly, the therapeutic potential of DP cells extends far beyond inducing new hair follicles. To study, or eventually correct, a wide variety of degenerative disorders, induced pluripotent stem (iPS) cells are being generated from patient biopsies

Now what DICKHEAD? So smart arent you.

[youngin]

Iron_Man need pictures to help? Iron_Man can't read real good?

[534623]

I like this part most:

"Surprisingly, the therapeutic potential of DP cells extends far beyond inducing new hair follicles."

Sure, because of the surprising therapeutic potential of DP cells (which extends far beyond inducing new hair follicles, of course) - you losers are still bald!!

[Thinning87]

I like this part most:


Sure, because of the surprising therapeutic potential of DP cells (which extends far beyond inducing new hair follicles, of course) - you losers are still bald!!

really this is all you have? You are going so low now, it's like you're drilling underground and it's hard to even insult you again...

just because you consider yourself irreversible and are depressed, you shouldn't be here trolling others around, especially those of us who report serious research and findings.

[Pentarou]

Boldy, serious real question: have you considered starting a Kickstarter fund to get your DP culturing/Asian lab hiring plan into action? I mean that genuinely.

[Thinning87]

Boldy, serious real question: have you considered starting a Kickstarter fund to get your DP culturing/Asian lab hiring plan into action? I mean that genuinely.

I'd be happy to chip in, but this is a serious effort which requires serious budgeting and serious efforts... I don't think you just start a lab like that, although I'd be happy to see this take off

[Pentarou]

I'd chip in too, if Boldy too it that far. I'm 100% serious.

Oh, and Iron Man is an appalling waste of carbon.

[UK_]

I'd chip in too, if Boldy too it that far. I'm 100% serious.

Oh, and Iron Man is an appalling waste of carbon.

No offence, but he probably knows more about hair loss than you. Just saying.