Homemade PGD2 Inhibitor

[ngallagher]

Quercetin

Applying quercetin topically seems like a lot of work. I personally am interested in minimizing hair loss, can't speak to and am not interested in new hair growth too hard to track/tackle.

Quercetin- is fat soluble when taken with meals.

Dihydroquercetin - is water soluble.

I've noticed a decrease in hair loss from say 10-15 hairs daily to 1 - 2 hairs since starting recent supplement protocol including quercetin/bromelain 400mg 3 times daily with meals.

Bumped up calcium/magnesium intake to 450mg 3 times daily with meals. Calcium is anti-stress lowering PTH and balances high phosphorous intake with my high protein diet.

Limit polyunsaturated fat intake and high iron intake as much as possible - both implicated in oxidation/inflammation.

Calcium lowers iron absorption when taken with meals. Magnesium lowers insulin resistance and both are generally anti-stress ( good for hair loss)...Ray Peat/Danny Roddy.

Hoping I can rock the "chrome dome" like Telly Savalas or Mr. Clean.

[TO YOUNG TO RETIRE]

PDG2 blocker plus wounding and corect time window=full regrowth

[optimisticyouth]

Applying quercetin topically seems like a lot of work. I personally am interested in minimizing hair loss, can't speak to and am not interested in new hair growth too hard to track/tackle.

Quercetin- is fat soluble when taken with meals.

Dihydroquercetin - is water soluble.

I've noticed a decrease in hair loss from say 10-15 hairs daily to 1 - 2 hairs since starting recent supplement protocol including quercetin/bromelain 400mg 3 times daily with meals.

Bumped up calcium/magnesium intake to 450mg 3 times daily with meals. Calcium is anti-stress lowering PTH and balances high phosphorous intake with my high protein diet.

Limit polyunsaturated fat intake and high iron intake as much as possible - both implicated in oxidation/inflammation.

Calcium lowers iron absorption when taken with meals. Magnesium lowers insulin resistance and both are generally anti-stress ( good for hair loss)...Ray Peat/Danny Roddy.

Hoping I can rock the "chrome dome" like Telly Savalas or Mr. Clean.

You only shed a couple of hairs per day? Is that even possible?? I've heard the "shedding 100 hairs per day is normal" claim, and even though I don't know how accurate that is, only shedding 2 hairs per day seems unlikely.

[greatjob!]

You only shed a couple of hairs per day? Is that even possible?? I've heard the "shedding 100 hairs per day is normal" claim, and even though I don't know how accurate that is, only shedding 2 hairs per day seems unlikely.

I've always laughed when people think they know how many hairs they shed per day. It's not possible to quantify the number of hairs you shed per day unless you confine yourself to a bubble for 24 hours. You may be able to tell if you are shedding more or less hair, but there is no way you can tell with any accuracy how many hairs you shed per day.

[lucrio]

So I looked up Quercetin and on wikipedia it says only 4% retention in the body when taken orally with most of it being excreted in urine. I'm assuming this means that it would be nearly useless to take this orally? I wonder if you could still apply it topically without the yellow staining problem. It seems unlikely though because it says on Wikipedia as well that qeurcetin is a pigment in plants, meaning it will be very colored wherever it is applied.

[bananana]

Applying quercetin topically seems like a lot of work. I personally am interested in minimizing hair loss, can't speak to and am not interested in new hair growth too hard to track/tackle.

Quercetin- is fat soluble when taken with meals.

Dihydroquercetin - is water soluble.

I've noticed a decrease in hair loss from say 10-15 hairs daily to 1 - 2 hairs since starting recent supplement protocol including quercetin/bromelain 400mg 3 times daily with meals.

Bumped up calcium/magnesium intake to 450mg 3 times daily with meals. Calcium is anti-stress lowering PTH and balances high phosphorous intake with my high protein diet.

Limit polyunsaturated fat intake and high iron intake as much as possible - both implicated in oxidation/inflammation.

Calcium lowers iron absorption when taken with meals. Magnesium lowers insulin resistance and both are generally anti-stress ( good for hair loss)...Ray Peat/Danny Roddy.

Hoping I can rock the "chrome dome" like Telly Savalas or Mr. Clean.

any update on this regimen?

[thechamp]

This has been tried before http://www.hairlosshelp.com/forums/m...threadid=36873

[35YrsAfter]

This has been tried before http://www.hairlosshelp.com/forums/m...threadid=36873

Tried ten years ago. The poster was kill.norwood. Would be nice if people followed up to let us know how their experimental treatment went. Medications like aspirin condition us to expect quick results. MPB can take years to run its course. A PGD2 inhibitor may only slow miniaturization or it could take years of persistent use to see any new growth. Since DHT has more than one detrimental effect on genetically predetermined follicles, an effective future treatment may require a combination of topicals and oral medication and could possibly include derma rolling for improved targeted absorption.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - Cole Hair Transplant Atlanta
The contents of my posts are my opinions and not medical advice

[idontwannagobald]

Did it work since its past a year now? I'm praying you still use this forum.

[doke]

When you mention Quercetin i notice that hair again gel has that in it i still have a new jar of that left i may start using it along with my other treatments.

[Vityok]

Hi there,

I was curious did the quercetin help you with your hair regrowth? Can you send me before and after pics.

Thanks

[maddy17]

Rutin is another phytochemical, your body can absorb it orally, and guess what? it converts it to quercetin. Also there is a product called Neuroprotek on Amazon from a major research doc on mast cells of Greek name from Tufts University. Which has Q, Rutin and Luteolin which is also a mast cell stabilizer and thus an inhibitor of PGD2. Nasty masties...so many problems with mast cells being over active.

[Just me]

How often

Hi Everyone,

I've been reading the forum for a few months now and suffer from some mild hair loss which got me to thinking...

Based on the studies associating PGD2 to MPB (and their binding effect upon the hair follicle which causes the follicle to shrink and become "dormant"), I believe (along with the University of Pennsylvania) that PGD2 is a likely culprit and when stopped can effectively regrow hair extensively.


Based on this I came up with the idea of designing a safe inhibitor of PGD2 at home.

Introducing... Quercetin. Quercetin is a natural supplement that is specifically known for its inhibition of PGD2. The problem is that when ingested orally, it doesn't absorb into the bloodstream, let alone reach the target area (scalp). Most of it is released from your body in your urine.

However, I believe that there is a way around this roadblock, and that way is to apply it directly to the scalp and allow it to absorb, resulting in the blocking of prostaglandin D2 and regrowing your hair.

Because Quercetin is highly water soluble, one may simply take a Quercetin tablet and put it in 1/4-1/3 cup of water till it mostly dissolves. There will be a little bit of particulate matter left if you buy the GNC variety (the variety that I used) because there are a couple other harmless compounds in there.

Now that you have Quercetin bonded with water molecules, you're ready to modify it to be absorb-able by the scalp. This doesn't happens with water molecules because the outer layer of your skin is very thick, but it does happen with oils. Any human friendly oil works, the most effective are jojoba and coconut oil.

So you take your Quercetin/Water mixture and add in an equal amount of oil as water you used to dissolve the Quercetin. It should not mix just yet, so it is time to add an emulsifier. This emulsifier would best be Lecithin (also available at GNC). Add Lecithin slowly until you have a completely homogeneous mixture, and you have now successfully created your very own PGD2 blocker that can be applied to and absorbed by your scalp.

I'm not sure if this has been proposed before, but I have designed this and have just started trying it on myself. If you decide to try it, please post photos and lets see if we can design a solution for MPB on our own!!

So to summarize the steps:

1. Place 1 Quercetin tablet in filtered water and stir till it dissolves
2. Add jojoba (or your favorite) oil to the mixture
3. Add Lecithin slowly until the oil and water mixture becomes homogeneous

At this point there should be VERY few solid particles in the mixture if you're using GNC brand product (Quercetin and Lecithin are both available there).

4. Apply the mixture to your scalp and allow it to soak in for at least an hour (thats how long I keep it in).

5. Keep posting and updating this thread to let me know if it works.

Hope this could possibly help!!!
-sksingh91




Because I absolutely have to post this below, please review the disclaimer:

As a disclaimer, I take no responsibility for your actions. Please be warned that by making this you are creating an otherwise untested substance. What you do is at your own risk. User sksingh91 makes no claims, promises, or guarantees about the accuracy, completeness, or adequacy of the contents of this thread, and expressly disclaims liability for errors and omissions in the contents of this thread. No warranty or liability of any kind, implied, expressed, or statutory, including but not limited to the warranties of non-infringement of third party rights, title, merchantability, fitness for a particular purpose or freedom from computer virus, is given with respect to the contents of this thread or its links to other Internet resources.

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Is this method done once or twice a day?

[Just me]

Is this method done once or twice daily?

[slimdog]

Did it work and how good?