I tried calling them, and they asked about my account password blah blah blah. Why do they make answering a simple question so difficult.
S-equol again
Collapse
X
-
Comment
-
Natures made realise date not looking promising
Michael,
Currently S-equol supplements are only available through the Sampling Trial and a launch date has not been announced. If you like to get more information please visit our website at www.naturalequol.com.Comment
-
Too early to make any assessments. I have never really noticed much shedding so I wouldn't see any change in that respect anyway. 10 weeks in on Monday at 48mg, 3 times per day. No idea on quantity if you are mixing with minoxidil. I did email Nature's Sunshine regarding the S vs R equol issue and got a quick reply stating that they would forward my question to the health science department.Comment
-
The product page for Nature's Sunshine Equolibrium states that "equol is a naturally occurring flavonoid found in some plants, including beans, cabbage and lettuce. It is a powerful antioxidant. Nature’s Sunshine’s Equolibrium uses a nature-identical source of equol derived from non-GMO daidzein."
I'm guessing that this is probably a racemic mixture since they are non-specific about it:
A "racemic mixture" is an equal mixture of two enantiomers - like 100 left shoes and 100 right shoes, or an equal collection of left & right gloves
It appears that it is possible to synthesize an R/S equol mixture from daidzein:
"Racemic (±)-equol can be synthesized from daidzein and formonetin, which
are readily available in sufficient quantities from plants or can be prepared by chemical synthesis."
You can produce pure s-equol using a certain bacteria (on daidzein, I believe):
"The pure S-equol enantiomer can be produced by microbiological methods"
They may be doing either, and they may be isolating the s-equol from the racemic equol. It's hard to say which, but I'm thinking it's a mix of R and S equol.Comment
-
The product page for Nature's Sunshine Equolibrium states that "equol is a naturally occurring flavonoid found in some plants, including beans, cabbage and lettuce. It is a powerful antioxidant. Nature’s Sunshine’s Equolibrium uses a nature-identical source of equol derived from non-GMO daidzein."
I'm guessing that this is probably a racemic mixture since they are non-specific about it:
A "racemic mixture" is an equal mixture of two enantiomers - like 100 left shoes and 100 right shoes, or an equal collection of left & right gloves
It appears that it is possible to synthesize an R/S equol mixture from daidzein:
"Racemic (±)-equol can be synthesized from daidzein and formonetin, which
are readily available in sufficient quantities from plants or can be prepared by chemical synthesis."
You can produce pure s-equol using a certain bacteria (on daidzein, I believe):
"The pure S-equol enantiomer can be produced by microbiological methods"
They may be doing either, and they may be isolating the s-equol from the racemic equol. It's hard to say which, but I'm thinking it's a mix of R and S equol.Comment
-
Not necessarily, it could be, but I think it's more likely something closer to 50% R-equol and 50% S-equol. That may or may not be terribly significant. R-equol binds dht as well, as far as I could tell. I am not sure if the two are metabolized the same, however, which may affect the dosage. I plan to look into that when I get a chance.
I've been taking about 36 mg / day (12mg every ~8 hours) of Nature's Sunshine Equolibrium for 2 months now. Not long enough for any changes. In retrospect, I do think a blood test would've been a good idea before and after starting it.Comment
-
Not necessarily, it could be, but I think it's more likely something closer to 50% R-equol and 50% S-equol. That may or may not be terribly significant. R-equol binds dht as well, as far as I could tell. I am not sure if the two are metabolized the same, however, which may affect the dosage. I plan to look into that when I get a chance.
I've been taking about 36 mg / day (12mg every ~8 hours) of Nature's Sunshine Equolibrium for 2 months now. Not long enough for any changes. In retrospect, I do think a blood test would've been a good idea before and after starting it.Comment
-
And are you getting any side effects (limp dick, etc...)?Comment
-
I still think we are going to have to wait for natures made s equol because it doesn't look like natures sunshine is 100 percent s equol , and a user has already been on natures sunshine product for two months with no changes not looking goodComment
Comment