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  1. #1
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    Default Histogen – TrichoScan analysis vs. side-by-side comparison

    I had 2 questions in this Histogen thread

    Anyway, here are the answers:


    According to the inventor of the TrichoScan device (they also used this device during Histogen’s clinical trails) in this paper …

    http://trichoscan.com/media/download...trichoscan.pdf

    … the analyzed area in the pic is about 2 cm² and shows about 400 hairs. Due to the fact, that 1 so-called “follicular unit” consists of 1-4 hairs (mean = 2.5 hairs), the area in the pic shows about 160 FU’s (follicular units).

    In addition, on TrichoScan’s website they explain …

    http://trichoscan.com/pages/english/...n-research.php

    … that especially for clinical trails and research results they use, in addition, a special “Research Software” – and according to the table below on this page, the “analysed area is up to 2 cm²”.

    Conclusion
    The analyzed areas of Histogen’s “macro-photos” show an AREA of about 2 cm² - right?

    An average Caucasian has an FU-density of about 80 FU’s (+/-) per 1 cm² - at least within his occipital region - right? So if you count about twice as much FU’s within a given area (e.g. +/- 160 FU’s), we are talking about an analyzed area of about 2 cm² - right?

    All in all, you can conclude that Histogen’s TricoScan macro-photos show an AREA of about 2 cm².

    Yes, indeed …

  2. #2
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    Default

    On Thursday, May 10, 2012, Histogen presented the following during the 2012 annual SID meeting:

    http://www.histogen.com/downloads/si..._HSC_Final.pdf

    I enlarged this pdf-file and simply took a screen shot of the before/after pics of trail subject “S2018” – here it is:


    In the next step, I tried to count the follicular units (FU’s) within the analyzed area …


    And finally, I did the following:
    TrichoScan
    http://trichoscan.com/media/download...trichoscan.pdf
    However, conventional visual hair counts are still performed and although no side-by-side comparison is available, visual hair counts are defined as the most precise method of measurement.
    In our view, this might be the case when only the number of hairs in a very
    small scalp area is counted. However, a rather large scalp area (up to 2 cm²) with about 400 hairs (fig. 1) is nearly impossible to accurately count for total, terminal and vellus hairs, hair thickness and hair growth rate.
    In fact, I simply enabled least a side-by-side FU comparison in this about 2 cm² area:


    Quote Originally Posted by Dr. Craig Ziering View Post
    Histogen's HSC study showed a statistically significant increase in the number of terminal hairs and hair thickness at 12 weeks. At the five month timepoint there was a decrease in hairs in a number of patients, but a significant increase again at 12 months, with the number of new hairs again reaching statistical significance at one year. There were approximately 25 new hairs per 0.1cc injection and the treatment effect was seen within 2mm of the injection site.

    The HSC works by stimulating stem cells in the dermal papilla of the hair follicle to grow new hairs. It also seems that stem cells in the scalp can be stimulated to grow into new hair follicles. This has been shown to be possible in the mouse model using the components that are part of HSC and so Histogen's trial really substantiates in patients with male pattern baldness what has been shown to be possible in mice for the past few years.

    Doc Z
    Within 2 mm of the injection site?
    WHERE are the “approximately 25 new hairs per 0.1cc injection” in this area (S2018)?

    … because I assume that Histogen didn’t use the “worst-case-subject pics” for a SID presentation.

  3. #3
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    Are you sure you counted right?
    I see hairs that lack a green dot in the two pictures

    And what is your definition of A FU? Hairs that are together but seem to come from diferent places sometimes get two or three dots and other times just one

  4. #4
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    Default

    You have WAY too much time on your hands...

  5. #5
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    Quote Originally Posted by garethbale View Post
    You have WAY too much time on your hands...
    Instead of, I should do - what exactly?

    Reading thousand user-posts to find out whether or not something is working as claimed?

  6. #6
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    Quote Originally Posted by bigentries View Post
    Are you sure you counted right?
    I see hairs that lack a green dot in the two pictures
    Correct, I forgot to mark a few hairs/FU's - in BOTH pics (before/after) ...


    But it doesn't matter - that's the reason why I made this sign -> ~

    Anyway, load the pic above down, and cover up my green dots with another color - and count the clicks/dots during making them again. Let me know YOUR numbers ... that's actually the INTENTION of this thread - namely, to review my results.

  7. #7
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    Quote Originally Posted by 534623 View Post
    Instead of, I should do - what exactly?
    Get laid....

  8. #8
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    Quote Originally Posted by 534623 View Post
    Correct, I forgot to mark a few hairs/FU's - in BOTH pics (before/after) ...


    But it doesn't matter - that's the reason why I made this sign -> ~

    Anyway, load the pic above down, and cover up my green dots with another color - and count the clicks/dots during making them again. Let me know YOUR numbers ... that's actually the INTENTION of this thread - namely, to review my results.
    Dude chill out I'm not a scientist. I would not do it because I can't do it, I don't know what the definition of FU, I don't have the knowledge to do it right

    I just pointed out some flaws in your analysis

  9. #9
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    Quote Originally Posted by 534623 View Post
    Instead of, I should do - what exactly?

    Reading thousand user-posts to find out whether or not something is working as claimed?
    Go out for a beer...chat to girls etc

  10. #10
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    Quote Originally Posted by bigentries View Post
    Dude chill out I'm not a scientist.
    But you're able to count, you know, 1, 2, 3 ...

    Quote Originally Posted by bigentries View Post
    I don't know what the definition of FU
    Follicular Unit - Plain Speak

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