Histogen show "cosmetic" results oct 2012 update

[Kirby_]

Desmond84, I think you've identified why old-timers are so negative! They've seen so many bloody worthless things come and go. I did similar to you a while back and trawled back through hairloss forum posts to 2002, it's depressing. Still, I hope that we see light at the end of the tunnel soon, whther through expensive 'super treatments' or the Prostaglandin model, hopefully both.

[Desmond84]

Desmond84, I think you've identified why old-timers are so negative! They've seen so many bloody worthless things come and go. I did similar to you a while back and trawled back through hairloss forum posts to 2002, it's depressing. Still, I hope that we see light at the end of the tunnel soon, whther through expensive 'super treatments' or the Prostaglandin model, hopefully both.

You know Kirby, right now we have TWO therapies in Phase 2 trials (Histogen & Aderans) BOTH showing very positive results, with solid financial backing and a great pool of cutting edge scientists.

On top of that we have a product called Replicel in Phase I, which showed to be even more effective than Aderans in pre-clinical trials. Now, they're lagging behind, they wont release a 12 month update, their 6 month update wasn't that great. I know all that, trust me! But, they're still moving forward, and who knows what they're seeing right now as we speak at the 12 month follow-up.

We have a great future ahead of us that looks very promising.

I mean I look back at 90's and all Merck scientists could think of was: "well this race of men in Dominican republic can't produce DHT and don't go bald! So, we should just knock this major hormone out of men to stop baldness" - I mean seriously...

Guys, we are so close to the light! be happy! go to parties! find a gf, live a happy life...science will bring you the answers you've been seeking all this time patience is a virtue.

And to all the old timers, I respect you all guys and your wise words should always be heard. But maybe this time, science has found the answer and it doesnt involve a natrual alternative!

- Peace

[gmonasco]

I mean I look back at 90's and all Merck scientists could think of was: "well this race of men in Dominican republic can't produce DHT and don't go bald! So, we should just knock this major hormone out of men to stop baldness" - I mean seriously...

Errr, no. Finasteride was developed by Merck as a treatment for enlarged prostates, not hair loss. That it also produced slight hair regrowth in some men with MPB was an unexpected and unintended side effect.

[Desmond84]

Errr, no. Finasteride was developed by Merck as a treatment for enlarged prostates, not hair loss. That it also produced slight hair regrowth in some men with MPB was an unexpected and unintended side effect.

Hey GMONASCO,

here's a bit of history I dug out of my Pharmacology book:

"In 1974, Julianne Imperato-McGinley of Cornell Medical College in New York attended a conference on birth defects. She reported on a group of hermaphroditic children in the Caribbean who appeared sexually ambiguous at birth, and were initially raised as girls, but then grew external male genitalia and other masculine characteristic post-onset of puberty. Her research group found that these children shared a genetic mutation, causing deficiency of the 5α-reductase enzyme and male hormone dihydrotestosterone (DHT), which was found to have been the aetiology behind abnormalities in male sexual development. Upon maturation, these individuals were observed to have smaller prostates which were underdeveloped, and were also observed to lack incidence of male pattern baldness.

In 1975, copies of Imperato-McGinley's presentation were seen by P. Roy Vagelos, who was then serving as Merck's basic-research chief. He was intrigued by the notion that decreased levels of DHT led to the development of smaller prostates who lacked androgenetic alopecia. This led to development of the first Type 5 alpha-reductase inhibitor known as Finasteride".

- True story

[Conpecia]

Pwned

10char

[NotBelievingIt]

I'm fairly certain they didn't come out with finasteride to help hair loss. They thought it might have an affect, but it was secondary to the reason they came out with it in the first place.

The power it had was likely the unexpected part.

[yeahyeahyeah]

Hey GMONASCO,

here's a bit of history I dug out of my Pharmacology book:

"In 1974, Julianne Imperato-McGinley of Cornell Medical College in New York attended a conference on birth defects. She reported on a group of hermaphroditic children in the Caribbean who appeared sexually ambiguous at birth, and were initially raised as girls, but then grew external male genitalia and other masculine characteristic post-onset of puberty. Her research group found that these children shared a genetic mutation, causing deficiency of the 5α-reductase enzyme and male hormone dihydrotestosterone (DHT), which was found to have been the aetiology behind abnormalities in male sexual development. Upon maturation, these individuals were observed to have smaller prostates which were underdeveloped, and were also observed to lack incidence of male pattern baldness.

In 1975, copies of Imperato-McGinley's presentation were seen by P. Roy Vagelos, who was then serving as Merck's basic-research chief. He was intrigued by the notion that decreased levels of DHT led to the development of smaller prostates who lacked androgenetic alopecia. This led to development of the first Type 5 alpha-reductase inhibitor known as Finasteride".

- True story

So in other words fin will chemically castrate you.

[Pate]

The point is, the role of 5AR in both BPH and MPB was known before the first 5AR inhibitor was developed. So it wasn't altogether unexpected when fin had an effect on hair loss. However, it was developed for prostate first.

Kind of like how the new generation of antiandrogens all seem to be targeted at acne first. It's incredible but pharma companies really don't seem to be interested in MPB treatments.

[Losing_It]

Any news if Spencer will have an interview with either Gail or Ziering? I also see that the ReGenica line of skincare products cost between $150 to $175. I wonder what that means for HSC since both products contains fibroblasts.

[Desmond84]

I'm fairly certain they didn't come out with finasteride to help hair loss. They thought it might have an affect, but it was secondary to the reason they came out with it in the first place.

The power it had was likely the unexpected part.

That's exactly right!

In the 80's, the scientific community had so many diseases to deal with that AGA was really not on their priority list.

I mean if you flip through the pharmacopoeia books from 1970s and early 80s, they were hundreds of times smaller, with far less drugs listed in them. From the pharmaceutical industry's point of view, there was simply far bigger fish to fry. There were still no real treatments available for major diseases like: Diabetes, Hypertension, High cholesterol, Angina, Heart attacks, Stroke, and Cancer!

Luckily today, a lot of these major medical burdens have been resolved or at least kept under control which has shifted the pharma companies attention towards untapped markets that were not explored in the past like hair loss.

To make things even better, we are lucky enough to live in an era where the "Human genome project" is completed, the medical world is being flooded with state of the art "biological" therapies, and the regenerative medicine is booming!

Now, these TWO important factors happening coincidentally at the same time has created a perfect environment for developing a permanent solution for hair loss. One that would involve a biological approach

These are exciting times indeed. Just flipping through some TED talks would simply make you gawk at the things in the pipeline and are coming out in just a few years.

Being involved in trials myself and a great admirer of science in general, I can promise you all this much. Things are looking incredibly bright for every human being walking this earth right now. So there's no reason to feel down or upset about a receded hairline or a thinning crown. The solutions are closer than you think and will be here b4 you know it. Just hang in there and enjoy everyday like its your last. Otherwise whats the point of living? right?

Peace out to all my balding brothers and sisters. Love you all

- Des