Hey guys,
I thought it was really odd how Cetirizine had shown no effect on PGD2, particularly since Cetirizine is far more effective than Loratadine (Claratyne) & Fexofenadine (Telfast) when it comes to
SKIN allergies.
So I did a lot of digging and found that within 5 hours of its oral use it inhibits PGD2 production in the skin by at least 50%!
I think the previous study was looking at PGD2 levels in nasal mucosa. I guess it makes sense. For example, antihistamines don't seem to work when you have a runny nose due to a cold (minimum effect on PGD2 in the nose) so we have to resort to Sudafed (Pseudoephedrine) to dry up and unblock our nose
Here's a study for you guys to look at. This was conducted during its approval process
http://www.ncbi.nlm.nih.gov/pubmed/2469708
So, stick to Cetirizine for now, until I dig up more info on Cromolyns.
P.S. If Cromolyns are more effective, there's a product called INTAL SPINCAPS, which are Cromolyn based capsules that go into a inhaler device. We can just open one capsule everynight, mix it with Emu oil & Propylene Glycol & voila
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