A PGD2 blocker (GPR44 blocker) which has finished phase III trials

[noisette]

hahaha... Our dogs are cured for pattern baldness thanks to Atopix

[It's2014ComeOnAlready]

I posted this in another thread, but I'll post it here because it's worth reading....

I came across one of their studies which is pretty revealing:http://www.pubfacts.com/detail/23190...receptor-Gpr44.

Basically says that PGD2 inhibits the process of follicle neogenesis through the gpr44 receptor. Which means that in order to even get this process off the ground, one of the first things they need to do is block that receptor. This is easy to deduce since balding areas have 3x as much pgd2, and they are trying to allow new hairs to grow in balding areas. It would of course would need to be done topically, which means they already have a topical to inhibit pgd2.

My guess is that they are using a number of compounds in these trials, and also means that this compound is being trialled as well, instead of an additional trial to test it alone. It would make a lot sense, because it would save both time and money and they can get on with their wounding method, while testing a topical compound that blocks the gpr44 receptor.

The whole $2 million for a treatment, $20 million for follicular neogenesis thing also makes sense, because yes, they will need more time and money to give a bald man a full head of hair. The gpr44 blocker is part of the process, and could be released sooner as a treatment than regrowing all your hair.

I think this is great news for anyone looking for a new treatment.