Spencer Kobren Interviews Replicel's CEO Concerning Latest Clinical Trial Results

[UK_]

The trials results are nothing spectacular actually they are kind of disappointing.
Especially when we know they injected high dosage of DSC cells into the test area.
However if they go back to the drawing board, research this some more than who knows. We will see what time brings us. I hope they succeed.
But our knowledge of hair follicles is still too meager, there are perhaps some crucial growth factors or fillcle parts missing for this to work even better.

Intercytex phase 1: "Although it is too early to determine fully the differences between the sub-groups, the preliminary data are encouraging. In the first sub-group 2 patients out of 5 showed substantial increases in hair count (21 & 55%) at 24 weeks. In the second sub-group (5 patients in total) injected more recently, all patients showed substantial and visible increased hair counts at 6 and/or 12 weeks (13-105%). We believe this increased hair production is attributable to the interaction between the injected DP cells and the stimulated resident hair producing cells."

Intercytex release results that clearly beat that of Replicel - but where are they now? People are telling me Replicel have a better chance with worse results? lmfao.

[PvH]

tbt community trying to interpret and figure out the meaning of clinical results is amusing at best. how is it that the actual scientists that somewhat know what the hell they're doing doesn't disclose shit but the 'experts' on tbt talk about it as if they actually know what they're talking about? i guess it's satisfying to correct fellow idiots and feel good about themselves.

[DallasTreado]

MPB does not affect children.

Unfortunately, yes it does ... (children below 18 can be and are affected)

[PvH]

Unfortunately, yes it does ... (children below 18 can be and are affected)

calling late teens children is really stretching it hahahaha but yeah some get it earlier than others.

[DallasTreado]

calling late teens children is really stretching it hahahaha but yeah some get it earlier than others.

It isnt a stretch. It is a distinction between pediatric and adult patients. For example, when propecia says it isnt for children, they mean it is not for pediatric patients (below 18)

[Follicle Death Row]

Regrown hair from Histogen's treatment is expected to last as long as the patients original hair lasted. So if you started balding at 20 years old, the regrown hair from Histogen's treatment could reasonably be expected to last almost 20 years.

Hope that's the case but I'm not convinced it will be for us men anyway. I think the problem if you start the process at 20 is you've actually only been subjected to high DHT for about 6 or 7 years. So us men in that scenario presumably would only levels get 6 or 7 years before it started again. It would still be fantastic though.

[Follicle Death Row]

Intercytex phase 1: "Although it is too early to determine fully the differences between the sub-groups, the preliminary data are encouraging. In the first sub-group 2 patients out of 5 showed substantial increases in hair count (21 & 55%) at 24 weeks. In the second sub-group (5 patients in total) injected more recently, all patients showed substantial and visible increased hair counts at 6 and/or 12 weeks (13-105%). We believe this increased hair production is attributable to the interaction between the injected DP cells and the stimulated resident hair producing cells."

Intercytex release results that clearly beat that of Replicel - but where are they now? People are telling me Replicel have a better chance with worse results? lmfao.

Aderans own that intellectual property now I think. We hardly ever mention Aderans because of the Bosley connection but seems like they're going to wrap up phase 2 late this year or early next year. They're miles ahead of the chasing pack and have massive money behind them.

[UK_]

Aderans own that intellectual property now I think. We hardly ever mention Aderans because of the Bosley connection but seems like they're going to wrap up phase 2 late this year or early next year. They're miles ahead of the chasing pack and have massive money behind them.

We dont mention Aderans because:

https://www.youtube.com/watch?v=C7SwA1ENqxI

[UK_]

tbt community trying to interpret and figure out the meaning of clinical results is amusing at best. how is it that the actual scientists that somewhat know what the hell they're doing doesn't disclose shit but the 'experts' on tbt talk about it as if they actually know what they're talking about? i guess it's satisfying to correct fellow idiots and feel good about themselves.

Yes, hilarious, especially when you retrive all the old posts back from 2007 when people were talking about how the Intercytex phase 1 result is absolute proof that new hair can be grown by injecting cells into the scalp, it's like injecting the smallest cellular component of a bladder & expecting a bladder to appear on your skin.

Also funny how even when Intercytex was opened for research again, the hair loss (DP cell) treatment wasnt even on their agenda (http://www.intercytex.com/index.php?...&id=3&Itemid=4) - - -<<<And still isnt LOL, and can anyone name me another company/scientist/researcher/investor since the closure of Intercytex that has decided to attempt the trial once again? (bar the two obvious Aderans/Replicel). You'd think people would be jumping in, especially a with market potential in the billions.

Excuses excuses, face facts... it just doesnt work.

P.S. Anyone holding in any results from Aderans other than the scetchy couple of pictures of a few hairs released back in 2010? Didnt think so.

[Tracy C]

So us men in that scenario presumably would only levels get 6 or 7 years before it started again.

Does that help you see the importance that others are missing about being able to immunize hair follicles from the damaging effects of DHT?

[Follicle Death Row]

Does that help you see the importance that others are missing about being able to immunize hair follicles from the damaging effects of DHT?

Oh yeah of course. I mean if Replicel could achieve that (though I still consider he results thus far poor) it would be great for those in the early stages but we just can't know that now; I have feeling though that it won't unless it's done periodically based on some other cellular therapies that exist.

As for Histogen, well let's wait and see.

[Tracy C]

If Replicel's treatment does in fact immunize hair follicles from the damaging effects of DHT, which it is reasonable to expect that it would, this would be helpful to everyone with hereditary hair loss. Not just those in the early stages. You need to look at the big picture. Not just a small part of it. Addressing the cause of hereditary hair loss is the most important part of the resolving the problem. Once that is achieved, the rest will follow.

The final outcome of Replicel's treatment this round is not yet known - and won't be for another six to 12 months. Sure it would have been great if they had achieved better results this early on - but the results they do have thus far are still significant.

[jman91]

If Replicel's treatment does in fact immunize hair follicles from the damaging effects of DHT, which it is reasonable to expect that it would, this would be helpful to everyone with hereditary hair loss. Not just those in the early stages. You need to look at the big picture. Not just a small part of it. Addressing the cause of hereditary hair loss is the most important part of the resolving the problem. Once that is achieved, the rest will follow.

The final outcome of Replicel's treatment this round is not yet known - and won't be for another six to 12 months. Sure it would have been great if they had achieved better results this early on - but the results they do have thus far are still significant.

surely then if you had lost your hair already the treatment would not be an option?

[Tracy C]

There is absolutely no valid reason to make that assumption.

[jman91]

There is absolutely no valid reason to make that assumption.

well actually i think its a very reasonable concern.

I have always thought that researchers and big pharma will only find a way/ be bothered to help people by preventing them losing hair, i don't think reversing hair loss is a realistic target, both scientifically and commercially in the long run so they wont bother.