'S-equol Topical made buy chemist thread

[lilpauly]

Jazz price might be s problem , we might need to contact the supplier that is selling the pills and see if they can sell her piwder

[PinotQ]

Again, I thought S-equol worked by binding to free DHT in the bloodstream, making it chemically inert at least vis-a-vis the androgen receptors. Seems to me this would make a topical near worthless! What am I missing?

Thanks.

Saltynuts,

The lead researcher for the past 20 years has suggested that equol for hair loss might be much more efficient and effective as a topical. If you read the research article: http://onlinelibrary.wiley.com/doi/1...87B557F.f03t03 (You have to rent or buy the full research article), you will see see that a 1.2 % concentration of equol in DMSO completely neutralized DHT in the skin in vitro. I don't think they are suggesting that equol binds to the androgen receptor when applied topically but more so that the concentration of equol brought to bear by application directly at the source of the problem (the scalp) may be able to neutralize scalp DHT by overwhelming and attaching to the DHT in the scalp. This of course doesn't mean that the results will translate in vivo or that a 1.2% solution will be potent enough in vivo but it does create an interesting possibility. FYI Equol is soluble in both DMSO and ethyly alcohol at the same concentration.

[inbrugge]

Has anyone used this? I'm guessing because it deals with DHT there are same potential side effects as RU and Fin?

[lilpauly]

Has anyone used this? I'm guessing because it deals with DHT there are same potential side effects as RU and Fin?

the profile is actually quite nice , it should have a lower chance of sides then fin or RU

[NeedHairASAP]

did we find a source yet?

https://www.caymanchem.com/app/templ...talog/10010173

http://www.enzolifesciences.com/ALX-385-032/r-s-equol/

[Saltynuts]

Saltynuts,

The lead researcher for the past 20 years has suggested that equol for hair loss might be much more efficient and effective as a topical. If you read the research article: http://onlinelibrary.wiley.com/doi/1...87B557F.f03t03 (You have to rent or buy the full research article), you will see see that a 1.2 % concentration of equol in DMSO completely neutralized DHT in the skin in vitro. I don't think they are suggesting that equol binds to the androgen receptor when applied topically but more so that the concentration of equol brought to bear by application directly at the source of the problem (the scalp) may be able to neutralize scalp DHT by overwhelming and attaching to the DHT in the scalp. This of course doesn't mean that the results will translate in vivo or that a 1.2% solution will be potent enough in vivo but it does create an interesting possibility. FYI Equol is soluble in both DMSO and ethyly alcohol at the same concentration.

Thanks PinotQ! So, won't these tablets work - just dissolve them in ethanol (and maybe some DMSO) at a 1.2% solution?

http://www.amazon.com/Natures-Sunshi...keywords=equol

Wait a second. These tablets are 6 freaking MG a piece? It would take 200 freaking tablets, or over $100 for a 1.2% solution?

[PinotQ]

Thanks PinotQ! So, won't these tablets work - just dissolve them in ethanol (and maybe some DMSO) at a 1.2% solution?

http://www.amazon.com/Natures-Sunshi...keywords=equol

Wait a second. These tablets are 6 freaking MG a piece? It would take 200 freaking tablets, or over $100 for a 1.2% solution?

I have experimented with this somewhat. A 1% concentration would take 887.205 mg dissolved in 3 oz. of alcohol (see this calculator http://www.physiologyweb.com/calcula...alculator.html (2.5735 ml per oz)). That's about 148 capsules or just shy of 2.5 bottles. Feel free to double check my math. However, if you try to dissolve this many capsules, you will end up with a lot of paste and less than 1 oz of alcohol. So I tried it at 1/2% concentration (74 capsules or about 1.25 bottles) and you get about 2 oz of alcohol after straining. To that you would add propylene glycol and water for 3 oz of product. I believe the minoxidil formula is 60% alcohol, 20% PG and 20% water. Again, nobody knows if this will absorb into the scalp enough to be effective but it's a possibility. If you were able to get a 1.2% solution absorbed down to the follicle, the research article suggests almost complete neutralization of DHT. I will be very surprised if somebody doesn't come out with a topical in the near future. There are several companies that use equol in products such as for the prostate (Nature's Sunshine & DesBio - Prostizine ), for weight loss (DesBio - EquolSlim), for skin maintenance and repair (NuSkin - AgeLoc) and for symptoms of menopause (Nature Made - S-Equol....not yet released)

[PinotQ]

Thanks PinotQ! So, won't these tablets work - just dissolve them in ethanol (and maybe some DMSO) at a 1.2% solution?

http://www.amazon.com/Natures-Sunshi...keywords=equol

Wait a second. These tablets are 6 freaking MG a piece? It would take 200 freaking tablets, or over $100 for a 1.2% solution?

FYI Here is a PDF on a DESBIO product for skin that cites some of the research. I believe this sells for about $50 an oz so not practical but it just points out that a topical can't be far behind from someone.

[PinotQ]

FYI Here is a PDF on a DESBIO product for skin that cites some of the research. I believe this sells for about $50 an oz so not practical but it just points out that a topical can't be far behind from someone.

Sorry.....forgot the pdf link: http://desbio.com/download/flyers/yu...actitioner.pdf

[Saltynuts]

Thanks PinotQ. I'll give it a go. Are those tablets I linked the cheapest ones you are aware of? Gonna be a pricey trial, but what the hey.

Thanks.