Measuring DHT levels to minimize chance of side effects?

[mathmoose]

Hi guys,

It's possible to get blood tests that reveal your levels of DHT.

Apparently a healthy ratio of testosterone to DHT is about 10:1. See here: http://www.androbalance.co.uk/malehormones-dht.htm

I'm guessing that those of us with MPB and thus higher levels of DHT, obviously have a different ratio... say, 10:4.

Taking finasteride obviously lowers DHT levels.

Do you think it's conceivable that if you take finasteride but monitor your DHT levels to ensure it stays in a healthy ratio, that the chances of side effects would be reduced?

Perhaps the 1mg dose or whatever it is, is a bit of a generic solution and some people need more while some need less.

If you noticed your DHT levels getting too low (i.e. the ratio becoming less than 10:1) then you could lower your dosage of fin until the ratio is corrected?

Does this seem conceivable or is it too obvious?

In my opinion, to prescribe the same dosage of anything to everyone is wrong. We're different sizes with different hormonal balances so while 1mg might be enough for 1 person, it's completely possible that it could be too high a dose for someone else and cause problems.

Thoughts?

[CurlyBird]

First off, higher levels of DHT do not cause balding. Genetic predisposition to going bald in the presence of DHT causes it. Now if you have higher than normal DHT then yes it will speed things up. But if that gene is there, you are going to go bald no matter what.

Also, the dose response is basically the same from .05-5mg. So adjusting the dose isn't going to do anything. What you're suggesting isn't really doable, especially as the total amount of the drug in your system accumulates over time. You would be talking measuring doses in the hundredths of milligrams or possibly thousandths.

Also, how do you intend to monitor your DHT levels anyway? You can't get a blood test done every day.

I'm not sure why you're worried about the ratio of T : DHT unless you are concerned with extra estradiol being produced from the excess T, which is more of an issue, as is the DHT:Estradiol ratio. But suppressing estradiol will require either high doses of zinc or an aromatase inhibitor.

[mathmoose]

Hey man,

As I say, I was just throwing the idea out there. I don't know how realistic it is, but it kind of made sense. Did you read the article at the link I posted?

It kind of alluded to what I was saying.

[CurlyBird]

I looked at it. I just don't see how you are going to control the T to DHT ratio to that degree. Or why it matters?

[mathmoose]

Well seeing as finasteride simply lowers DHT levels and can reverse hair loss, surely it's the higher DHT level causing hair loss in the first place?

[CurlyBird]

Well seeing as finasteride simply lowers DHT levels and can reverse hair loss, surely it's the higher DHT level causing hair loss in the first place?

No, it is the androgen sensitivity of the hair determined genetically. If you don't have the right genes you can't develop AGA.