CB-03-01 - new antiandrogenic

[inbrugge]

lilpauly, can we assume cb gives great results with no side effects if it is used the same way it was used in cosmo's first set-up with iontophoresis (i think it was once a week application! no?)

why not replicate that set-up? iontophoresis devicss aren't that expensive (200$-500$) and at one application per week with those results it'll definitely be worth it (and cb will be affordable at that low amount of usage).

in fact, iontophoresis can also improve other existing applications like minox, ru, dut, fin, etc.

so why don't we find a way to replicate cosmo's first application? do you know anyone who can help us achieve this? maybe kane has some knowledge about this?

[lilpauly]

lilpauly, can we assume cb gives great results with no side effects if it is used the same way it was used in cosmo's first set-up with iontophoresis (i think it was once a week application! no?)

why not replicate that set-up? iontophoresis devicss aren't that expensive (200$-500$) and at one application per week with those results it'll definitely be worth it (and cb will be affordable at that low amount of usage).

in fact, iontophoresis can also improve other existing applications like minox, ru, dut, fin, etc.

so why don't we find a way to replicate cosmo's first application? do you know anyone who can help us achieve this? maybe kane has some knowledge about this?

to be honest with bro I'm not that convinced with the ionto . I'm not even that convinced that much with the first trail they did . What do all these trials have in common ? They all grow trendnous amount of hair !!! It's to get investors .

[lilpauly]

look at this study


Background

Latanoprost is a prostaglandin analogue used to treat glaucoma. It can cause adverse effects, such as iridial and periocular hyperpigmentation, and eyelash changes including pigmentation and increased thickness, length, and number. Latanoprost has been used to treat eyelash alopecia, but knowledge on its effects on human scalp hair growth is not available.

Objective

The primary objectives were to assess the efficacy of latanoprost on hair growth and pigmentation. The secondary objectives were to assess the effect on scalp pigmentation; investigate the treatment duration needed to affect hair growth, hair pigmentation, and scalp pigmentation; and assess safety of latanoprost.

Methods

Sixteen men with mild androgenetic alopecia (Hamilton II-III) were included. Latanoprost 0.1% and placebo were applied daily for 24 weeks on two minizones on the scalp. Measurements on hair growth, density, diameter, pigmentation, and anagen/telogen ratio were performed throughout the study.

Results

At 24 weeks, an increased hair density on the latanoprost-treated site was observed compared with baseline (n = 16, P < .001) and placebo-treated site (P = .0004).

Limitations

Only young men with mild androgenetic alopecia were included. The results may not be applicable to other patient groups. Choice of investigational site may have affected the results.

Conclusions

Latanoprost significantly increased hair density (terminal and vellus hairs) at 24 weeks compared with baseline and the placebo-treated area. Latanoprost could be useful in stimulating hair follicle activity and treating hair loss.

[lilpauly]

look at this study


Background

Latanoprost is a prostaglandin analogue used to treat glaucoma. It can cause adverse effects, such as iridial and periocular hyperpigmentation, and eyelash changes including pigmentation and increased thickness, length, and number. Latanoprost has been used to treat eyelash alopecia, but knowledge on its effects on human scalp hair growth is not available.

Objective

The primary objectives were to assess the efficacy of latanoprost on hair growth and pigmentation. The secondary objectives were to assess the effect on scalp pigmentation; investigate the treatment duration needed to affect hair growth, hair pigmentation, and scalp pigmentation; and assess safety of latanoprost.

Methods

Sixteen men with mild androgenetic alopecia (Hamilton II-III) were included. Latanoprost 0.1% and placebo were applied daily for 24 weeks on two minizones on the scalp. Measurements on hair growth, density, diameter, pigmentation, and anagen/telogen ratio were performed throughout the study.

Results

At 24 weeks, an increased hair density on the latanoprost-treated site was observed compared with baseline (n = 16, P < .001) and placebo-treated site (P = .0004).

Limitations

Only young men with mild androgenetic alopecia were included. The results may not be applicable to other patient groups. Choice of investigational site may have affected the results.

Conclusions

Latanoprost significantly increased hair density (terminal and vellus hairs) at 24 weeks compared with baseline and the placebo-treated area. Latanoprost could be useful in stimulating hair follicle activity and treating hair loss.

*********With 6 months of 0.1% latanoprost in a 5/3/2 ethanol/pg/water vehicle on 16 living, breathing AGA men they achieved a 22% density increase********

[lilpauly]

that study is flawed . that study was from 3 years ago and it went no where .

[burtandernie]

hi man its in the clincal trials. http://clinicaltrials.gov/ct2/show/NCT02279823


i talked to some1 from cosmo last year and he mentioned it was going to be a gel.

Ah okay so its this recent trial they were doing they said that.

[lilpauly]

Ah okay so its this recent trial they were doing they said that.

Yes man they conclude in summer

[inbrugge]

i see what you mean about the cosmo trial but ionto in general, you don't think it has a lot of potential? you can guarantee direct delivery so you can use to much lower amounts of application and dosage meaning very little side effects. imagine topical dut with no side effects.

[lifelonglearning]

Is their anyone currently using CB? If so can you state your source , vehicle and experience using it

[chongmet]

Nobody has any method of verifying the results or lack thereof. Everything everyone has done so far has basically been just a shot in the dark. I'm not even fully convinced that the CB people are buying either from Iron Dragon, Kane or elsewhere is 100% real, I have my doubts.

So.We are in late 2015. Have you tried CB anyhow? I really want to give it a shot, but for a proper period of time, Like 1 year. Have you heard about someone who used it? Is the vehicle really an issue?