Here is his lab research Renee :
http://homepage.ntu.edu.tw/~d99548008/
His last studies Jun 2015:
Enhancing Hair Follicle Regeneration by Nonablative Fractional Laser
http://www.researchgate.net/publicat...ATION_BY_LASER
and this very very interesting one
A Two-Stepped Culture Method for Efficient Production of Trichogenic Keratinocytes
http://www.researchgate.net/publicat..._Keratinocytes
In tissue engineering,
the maintenance of trichogenic potential of adult epidermal cells while expanding them remains a
challenging issue. We found that though hair follicle outer root sheath keratinocytes could be expanded for more than 100 passages as clonogenic cells without losing the proliferative potential with a 3T3J2 fibroblast feeder layer, these keratinocytes were unable to form new hair follicles when combined with inductive hair follicle dermal papilla cells. However, when these high passage keratinocytes were co-cultured with hair follicle dermal papilla cells for 4 days in vitro,
they regained the trichogenic ability to form new hair follicles after transplantation. We found that the short-term co-culture with dermal papilla cells both
enhanced Wnt/β-catenin signaling, a signaling cascade key to hair follicle development, and upregulated the expression of hair follicle
specific genes, including K6, K16, K17 and K75, in keratinocytes, indicating these cells were poised toward a hair follicle fate. Hence,
efficient production of trichogenic keratinocytes can be obtained by a two-stepped procedure with initial cell expansion with a 3T3J2 fibroblast feeder followed by short-term co-culture with dermal papilla cells. "
05/2015
trichogenicity is a major issue in hair regeneration! Sounds good
ps: B catenin pathway= a signaling
cascade key #IamSAMUMED
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