Replicel

[oracle]

We need to see the data stratified by sex before getting down on the numbers. 9 of the 19 subjects were female. It seems to me that this treatment would more effective in men due to the quality cells in the male donor area. I don't think women have this stable donor area to pull cells from which, which could compromise their results.

[NotDyingBald]

I know how much we want to hear 500% regrowth guys.

But we need to interpretate the numbers released. We are not talking about regrowth after the use of Minox, Fin, or whatever, where the follicles producing hair are already there, hair strucutures are already formed. Don´t forget that this is introduncing new cells into the scalp, so it takes time for the body to establish them, evolve and finally start working(producing hair)

So, if from Minox we need at least 6 months to start seeing(if they are) results, and 1 year or more, from Fin, i think that having hair growth from new structures only 6 months after injection(and in phase 1), its definitely good news.

Oh, and with that little tiny detail: without having to take the chances of having your dick dead.

[NotDyingBald]

I know how much we want to hear 500% regrowth guys.

But we need to interpretate the numbers released. We are not talking about regrowth after the use of Minox, Fin, or whatever, where the follicles producing hair are already there, hair strucutures are already formed. Don´t forget that this is introduncing new cells into the scalp, so it takes time for the body to establish them, evolve and finally start working(producing hair)

So, if from Minox we need at least 6 months to start seeing(if they are) results, and 1 year or more, from Fin, i think that having hair growth from new structures only 6 months after injection(and in phase 1), its definitely good news.

Oh, and with that little tiny detail: without having to take the chances of having your dick dead.

I just quoted my own reply. Just because it seems to me that is one of the most sense replys about Replicel, and no one noticed it. Or maybe i´m just stupid.

[TrueGround]

I just quoted my own reply. Just because it seems to me that is one of the most sense replys about Replicel, and no one noticed it. Or maybe i´m just stupid.

I think that is one of the most sensible of the positive replies I've seen to this situation as well. It's exactly my thought process and how I wanted to respond to the results, but I couldn't think of how to put it into words at that moment, got busy, and said screw it after all the overwhelming bashing started pouring in.

I never jumped the Replicel ship, even after being disappointed in not seeing crazy regrowth. But after I washed away my sorrows with a couple ****tails and shrugged it off the next day, it almost started to make sense that there wasn't much regrowth at 6 months.

For instance, posters here have been referring to Histogen as possibly being "Minox on steroids" - coaxing follicles out of telogen phase into anagen via a potent dose of growth factors. However, Replicel took the approach of addressing the issue at a very early step in follicle genesis (as I understand it) with replicated ("brand new") DSC cells - at least one, if not several steps before Histogen's growth factor approach even comes into play. Essentially, the treatment is restarting from scratch or close to it. It only seems to make sense that it will take significant time for brand new follicle genesis, for that follicle to go through multiple "cycles" or processes we may not be aware of and then to be capable of generating a terminal hair (like in a baby's scalp^). It could also make sense that any vellous hair follicles would take considerable time to recruit DSC cells and tare down/rebuild, where as Histogen's growth factors are immediately, and unnaturally available - thus the hasty new or "coaxed" hair growth.

The above has been theorized with very little bio knowledge. But shit man, they grew hair on mice ears and feet! Plus D. Hall said a mouse's biological processes cycle much faster than a human's. I know they were mice, but it was approached at the cellular level. I don't see why it shouldn't work in humans once the (seemingly many) kinks are worked out.

I'm over being pissed about the prelim efficacy. I'd just be legitimately surprised if Replicel doesn't develop into SOMETHING viable, whatever those results might entail.

[Maradona]

I think that is one of the most sensible of the positive replies I've seen to this situation as well. It's exactly my thought process and how I wanted to respond to the results, but I couldn't think of how to put it into words at that moment, got busy, and said screw it after all the overwhelming bashing started pouring in.

I never jumped the Replicel ship, even after being disappointed in not seeing crazy regrowth. But after I washed away my sorrows with a couple ****tails and shrugged it off the next day, it almost started to make sense that there wasn't much regrowth at 6 months.

For instance, posters here have been referring to Histogen as possibly being "Minox on steroids" - coaxing follicles out of telogen phase into anagen via a potent dose of growth factors. However, Replicel took the approach of addressing the issue at a very early step in follicle genesis (as I understand it) with replicated ("brand new") DSC cells - at least one, if not several steps before Histogen's growth factor approach even comes into play. Essentially, the treatment is restarting from scratch or close to it. It only seems to make sense that it will take significant time for brand new follicle genesis, for that follicle to go through multiple "cycles" or processes we may not be aware of and then to be capable of generating a terminal hair (like in a baby's scalp^). It could also make sense that any vellous hair follicles would take considerable time to recruit DSC cells and tare down/rebuild, where as Histogen's growth factors are immediately, and unnaturally available - thus the hasty new or "coaxed" hair growth.

The above has been theorized with very little bio knowledge. But shit man, they grew hair on mice ears and feet! Plus D. Hall said a mouse's biological processes cycle much faster than a human's. I know they were mice, but it was approached at the cellular level. I don't see why it shouldn't work in humans once the (seemingly many) kinks are worked out.

I'm over being pissed about the prelim efficacy. I'd just be legitimately surprised if Replicel doesn't develop into SOMETHING viable, whatever those results might entail.

You guys are tripping ! Replicel doesn't have a good record and even if these results were true, who the hell needs microscopic hairs and unnoticeable increased density which are not even consistent on all patients.

Growing hair a mouse feet? Replicel's not the only one who has done it, all HM companies can do it. Replicel used their "patented" procedure consisting of DSC cells and DP cells, the latter used by ARI, and they got the exact same result on mouses feet.

The results were also the same in mouse's ear but the only difference is that the DSC cells did not cluster. This is the reason why replicel was born, they thought these DSC cells were the progenitor cells capable of regenerating the entire hair structure even affecting the AGA tissue around it for it's survival but it has FAILED to produce what they thought it could do.

This is all ADERANS all over again and aderans has solved the clustering problem with some tweaks.

Aderans is way ahead of replicel and want to market their procedure and they are trying to cure advanced stage pattern baldness.

Replicel's just trying to impress investors by growing some stuff on thinning areas to get some good results, sell their stuff and get paid. Wether they come to market or not, they do not care.

However all these companies will not cure MPB, they are not solving the root of the problem but simply prolonging the inevitable and for how long? apparently not enough to market it.

You guys need a reality check. Don't get me wrong I want this shit to be cured I am in no treatment whatsover but nothing is impressive so far.

Histogen results are somewhat impressive and lets hope they can last.

[BoSox]

Aderans is way ahead of replicel and want to market their procedure and they are trying to cure advanced stage pattern baldness.

What's a realistic release date for Aderans?

[67mph]

...Damn it!

Positivity didn't last long eh ...they're back!!

Once the threads get bumped, the 'know-it-alls' (minus the lab coats i notice??!) come crawling over for a sniff around.

This is a Replicel thread, Rep-li-cel.

Now go and fill in some wikipedia pages yeah.

[Follicle Death Row]

What's a realistic release date for Aderans?

If it's anything like other trials I'm thinking 2017. 5 years off.

Sure that's just speculating. I don't know how long it will take Aderans to get the infrastructure in place and how long a phase 3 trial they intend to run. It's complete guess work at this point but 2017 seems reasonable if they really are to wrap up phase 2 towards the end of this year or early next.

[UK_]

What's a realistic release date for Aderans?

id probably say 6780.

[Nilli57211]

We need to see the data stratified by sex before getting down on the numbers. 9 of the 19 subjects were female. It seems to me that this treatment would more effective in men due to the quality cells in the male donor area. I don't think women have this stable donor area to pull cells from which, which could compromise their results.

Actually if anything, I think it would work better in women, just as Rogaine has been shown to - the reason for this being that women's hair follicles aren't as "far gone" as men's. As for unstable donor cells, even if that were an issue, it doesn't seem like that would have an effect on these initial results (though possibly those hairs might fall out faster in the long run).

I think the negativity is ridiculous. They've produced results (though fairly small), they proved safety - and people are blasting them because they haven't cured baldness in their PHASE I trial. We all want a cure, so the negative comments aren't helping anyone, especially when they're not based on anything. Let the scientists do their jobs, live your lives, and understand that it's more about the big picture than every little set of seemingly disappointing results. Remember Histogen produced impressive results as well - there's more than one company working on this, and we really only need one of them to get it right.