JAK Inhibitors and Hair Loss - Dr. Angela Christiano Interview

[Link Mahboi]

So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




(sorry, had to get this off my chest)

[allTheGoodNamesAreTaken]

So, this won't do JAK shit for AGA, eh? Why am I not ****ing surprised? God, I might just end this miserable life already, there will be no cure, and even if something comes out, it will provide marginal results like 20% regrowth which, guess what, it won't make any ****ing difference at all. Maintenace IS NOT and it WILL NEVER BE a cure, most of us will be high norwoods by the time something better comes and it will be the same thing as paying high amounts ofmoney to mantain an old, ugly and broken Cadillac, just for the sake of saying you have one.
God Damn it, I hate nature with all my guts and I wish I could kick that slut in the ****ing ****, ****ing bitch lol




(sorry, had to get this off my chest)

Histogen undeniably works and the necessary trials will be completed in an acceptable timeframe. And it will cost only a fraction of a transplant. And bimatoprost works. And SM04554 seems to work. And Replicel/Shiseido claim a working product and have specified a not-too-distant release date too. Not sure why these facts haven't really been recognised yet but that's what they are. And these things also make transplants a viable option since requiring repeated operations and possibly running out of donor hair won't be an issue. The topic of this video is old news too, it was announced ages ago.

[jjo]

3 to 5 years...again

too late for many

[Thinning87]

Relax people.

Very interesting interview, thank you Spencer.

[champpy]

she was really beating around the bush when it came to answering that question. she did not want to give a definitive answer, although for some reason I think she knows. my guess, and this is my guess only, is that she is trying to prolong this as much as she can to get research money over the next five to ten years. as far as I know she doesn't own the rights to these drugs and wouldn't make any money if this is a cure or a fix. she's only getting money as a researcher, correct? if that's the case then the only way she makes money is by constantly researching.

again to me it seems like these rare problems (AA, vitiligo) are what's being addressed but it hits a small percentage of the population. These findings keep everyone interested about the drugs potential but MPB is not being touched. that's because MPB the big payday right and once that solved they are out of a job

there has been no information as to what concentration would work in a topical right? I would really love to ask my dermatologist to have this compounded but I have no idea what percentage to use

[Hemo]

she was really beating around the bush when it came to answering that question. she did not want to give a definitive answer, although for some reason I think she knows. my guess, and this is my guess only, is that she is trying to prolong this as much as she can to get research money over the next five to ten years. as far as I know she doesn't own the rights to these drugs and wouldn't make any money if this is a cure or a fix. she's only getting money as a researcher, correct? if that's the case then the only way she makes money is by constantly researching.

again to me it seems like these rare problems (AA, vitiligo) are what's being addressed but it hits a small percentage of the population. These findings keep everyone interested about the drugs potential but MPB is not being touched. that's because MPB the big payday right and once that solved they are out of a job

there has been no information as to what concentration would work in a topical right? I would really love to ask my dermatologist to have this compounded but I have no idea what percentage to use

She answered pretty clearly - there are simply no solid plans to look into its effectiveness for AGA. She said a company would have to decide to invest in testing it for AGA, refining its delivery, etc.

I would have rather heard her opinion on other drugs in testing (especially Samumed's, since I think she has helped with phase II in some sense). This isn't really much of an issue considering it would probably be 10 years to market if they started testing today (unless they can skip phase I due to the amount of data on Jak inhibitors, but it seems they have limited information on topical delivery).

[sdsurfin]

I don't get it. Why can Christiano test this in her lab for areata and not do preliminary studies for AGA? I get that funding a full on clinical trial is more complicated, but they didnt do a clinical trial for areata either, they just went for it. ??? confusing- anyone have any clarity on this? Also, this seems like way more of a no brainer for a pharma to jump on than the PGD2 stuff, the fact that they tested this on DP spheres and it had such a huge impact means that there's no way this doesnt have some positive effect for aga. JAK inhibitors clearly impact the follicle positively either way. Come on drug compaines- get on this!! Makes no sense that pharma wuld fund things like bimatoporst, which has such limited efficacy, and not this. Does anyone know of forum members trialling a JAK inhibitor topically? It didn't seem like christiano was particularly concerned about that, seems the drugs are really pretty safe. If I had the money, I'd do it.

[joachim]

I don't get it. Why can Christiano test this in her lab for areata and not do preliminary studies for AGA? I get that funding a full on clinical trial is more complicated, but they didnt do a clinical trial for areata either, they just went for it. ??? confusing- anyone have any clarity on this? Also, this seems like way more of a no brainer for a pharma to jump on than the PGD2 stuff, the fact that they tested this on DP spheres and it had such a huge impact means that there's no way this doesnt have some positive effect for aga. JAK inhibitors clearly impact the follicle positively either way. Come on drug compaines- get on this!! Makes no sense that pharma wuld fund things like bimatoporst, which has such limited efficacy, and not this. Does anyone know of forum members trialling a JAK inhibitor topically? It didn't seem like christiano was particularly concerned about that, seems the drugs are really pretty safe. If I had the money, I'd do it.

totally agreed! nothing will come out of it if we don't trial this on our own. we need to get our hands on JAK inhibitors asap! only thing is, we need some professional chemists who are able to create a nice formulation for absorbtion.
this JAK stuff seems promising and we have to wait another 3 to 5 years for first results? screw that! where are the pros of the usual group buys, with chemical know how? we need that stuff on our heads now!

[champpy]

I don't get it. Why can Christiano test this in her lab for areata and not do preliminary studies for AGA? I get that funding a full on clinical trial is more complicated, but they didnt do a clinical trial for areata either, they just went for it. ??? confusing- anyone have any clarity on this? Also, this seems like way more of a no brainer for a pharma to jump on than the PGD2 stuff, the fact that they tested this on DP spheres and it had such a huge impact means that there's no way this doesnt have some positive effect for aga. JAK inhibitors clearly impact the follicle positively either way. Come on drug compaines- get on this!! Makes no sense that pharma wuld fund things like bimatoporst, which has such limited efficacy, and not this. Does anyone know of forum members trialling a JAK inhibitor topically? It didn't seem like christiano was particularly concerned about that, seems the drugs are really pretty safe. If I had the money, I'd do it.

this is also been my point all along. they have tested it on people with AA, vitilgo, people that cannot grow eyebrows and I believe one other skin condition... All without an official clinical trial!

why can't they try it on people with AGA without a trial??

she even said in the interview, it either works or it won't and it won't take a long time to find out. so why not try it on a few people for a month or two, especially when the risk of side effects is solo topically.

screw this I'm making an appointment with my dermatologist next week to see what she thinks about this

[ShookOnes]

3 to 5 years...again

too late for many

Or none if you're on fin...if you're one if those people debating it, only old balding men who are bitter spread the fact it kills dick lol.