Acceleration in iPS cells clinical applications!!

[lacazette]

Interesting! A kind of peptide like that would be perfect to activate our hair stem cells!

Few articles I read and little hopeful:

Build to precisely control the cell functions at the "artificial circuit" With RNA https://translate.google.com/transla...ml&prev=search

"Furthermore, an artificial RNA is introduced into cells in culture on a petri dish, cancer cells only successfully leading to cell death. Precisely detects the state of the cell, because it can control the fate, identification and removal of cancer cells in response to intracellular conditions"

"The combination of these artificial circuits, because it can operate the fate of safely and precisely human cells, expected to be closer to the future medical applications."


-Using a genome-wide screening approach, scientists from Singapore identified novel regulators of human stem cells differentiation.
http://www.asianscientist.com/2015/0...nt-stem-cells/

"While previous studies were mainly performed in mouse embryonic stem cells, data from this work provides a starting point for future studies in the understanding of human embryonic stem cell differentiation. Furthermore, their mechanistic study provided an alternative view on the current understanding of the relationship between stem cell differentiation and cell cycle regulators"

"“Knowledge from this screen can be exploited to enhance differentiation protocols used to derive specific cell types from human embryonic stem cells,” Gonzales said."


-From pluripotency to totipotency
http://www.sciencedaily.com/releases...0804142955.htm

"While it is already possible to obtain in vitro pluripotent cells (i.e., cells capable of generating all tissues of an embryo) from any cell type, researchers have pushed the limits of science even further. They managed to obtain totipotent cells with the same characteristics as those of the earliest embryonic stages and with even more interesting properties. "

"Just after fertilization, when the embryo is comprised of only 1 or 2 cells, cells are "totipotent," that is to say, capable of producing an entire embryo as well as the placenta and umbilical cord that accompany it.
"For some years, it has been possible to re-programme differentiated cells into pluripotent ones, but not into totipotent cells. Now, the team of Maria-Elena Torres-Padilla has studied the characteristics of totipotent cells of the embryo and found factors capable of inducing a totipotent-like state."

[seanway]

Hey guys - Whilst on the subject of stem cells and regen medicine, take a read of this http://www.nature.com/labinvest/jour...t2015103a.html This peptide seems to activate stem cells... so urr would be awesome to see if it had any effect on the hair!

I know that the peptide is used in gastrointestinal damage but to target actual stem cells to activate is awesome.

I hope this can represent the cure

[JayM]

In terms of the peptide - It could be similar to what follicum are producing. Could also explain why they have the ability to kill hair and grow hair with only small changes.

[lacazette]

Yes you right Jaym, follicum seems to be a kind like that.


Regarding Singapore researchers, it may be more important that i thought:
http://www.sciencedaily.com/releases...0805141333.htm

"Singapore scientists from A*STAR's Genome Institute of Singapore (GIS) have, for the first time, found further evidence of how the differentiation of pluripotent cells is tied to and controlled by the cell cycle clock. This deeper understanding of how cells become differentiated is extremely important when considering therapeutic potentials."

There's a national skin center in Singapore and a research area regarding hair biology and regeneration:

https://www.nsc.com.sg/Research/Page...rch-Areas.aspx

Hair Biology and regeneration is a new niche area of research for NSC given its high prevalence and clinical relevance. The core aims to establish a cohort of patients with various hair diseases for genetic, epidemiological and clinical research .

It could be interesting there, aswell as South korea with sung jan li, who recently induced hair follicle neogenesis without the help of inductive hair follicle dermal papilla cells or newborn dermal cells:

http://www.nibs.ac.cn/en/lecture/Lin...n20150817.html

[JayM]

http://www.medicalnewstoday.com/releases/298753.php some good news for iPSC's

[lacazette]

Damn Jay , it's the biggest thing of the summer!the best new that we could ever had!

Fear of DNA mutations was the last major issue that was slowing every iPSC therapy to enter human clinical trial

the two others were:
-simply and cheaper methods for mass iPSCs production: already solved
-kill all the cells that failed to differentiate during the reprogramming process to have tumor free risk cells: solved by japanese researchers this july

The fear of DNA damage that could lead to mutations was the last and biggest problem that was slowing the process for mass clinical trials with iPSC treatments
(macular degenerence was the first and only one accepted and already taking place in trial in japan and usa, the slow process was ONLY because of that DNA damage fear)

Now this spanish team have just made the biggest progress on iPSCs since 2006 and it's discovery! It's huge huge huge


"A finding reveals why the transformation process of differentiated cells into stem cells results in significant damage to the DNA. Researchers have managed to rectify this damage using a simple modification to the culture medium

While the fact that the method damaged the DNA of iPS cells was known, the reasons were not.

According to an article published this week in Nature Communications, the team headed by Fernández-Capetillo states that the damage to the genome of iPS cells lies in a very specific kind of stress that the cells are subjected to during cell reprogramming: replication stress, which occurs when the cells increase the pace of division. In addition, and based on these findings, the authors of the paper have managed to develop strategies to reduce this type of stress, resulting in pluripotent stem cells with less damage to their genome.

The results represent a significant step forward regarding the possible use of iPS cells, because after almost a decade since they were developed, there is now a more efficient way of obtaining them, with less damage to the DNA, making them potentially safer.


The nature of the damage to the DNA observed in iPS cells has been intensely discussed for some years, due to the fact that it is linked to the rearrangement of large fragments of chromosomes which could lead to potentially dangerous mutations if used clinically

Now the team headed by Fernández-Capetillo has not only identified the origin of the damage, replication stress, but has managed to reduce it significantly; potentially improving the safety of induced stem cells for use in biomedicine

The simplicity of this nucleoside-based strategy means that it can be implemented easily by laboratories around the world working with iPS cells, and thus contribute significantly to the field of regenerative biology, one of the greatest aspirations of biomedicine this century.



With this incredible new jay combined with the tumor free risk cells new of july, that mean for Terskish team from S&B could have the autorisation to test his technique on human in a just a few weeks!!

Cause before the summer he was saying that he would need 2 years before enter clinical trial because of the safety issues. Now with those two major breaktrhoughs from this summer, it changes everything in the timelines!

Sisheido, regience, sung jan lin and all the others in the world could now planning for government authorisation for iPSC human trial testing in the coming weeks/months!! For the septics who don't believe it , just ask them directly (company/researchers) how these two breakthroughs of the summer change everything in term of timeline

and it's huge not only for our hair in the really near future, but it will also save a lot of us from death and major diseases that we were programmed to have in 10/20 years

So now let's just be careful when we drive our car,etc stupid accidents like this, cause we will really soon be able to enjoy our life at 100% with a beautiful Nwd 0 and without that baldness feeling in our stomach anymore

[JayM]

Man I love your optimism lacazette it's good news indeed. Were you in contact with any of these guys? It would be fantastic to know whether they are that excited about it. The funny thing is if you just think about it, the actual process is so simple to reduce mutations.

[lacazette]

Hehe how can I not be optimist when in one summer the major issues for clinical translation are being solved

With that new easy technique, many iPSC treatments will alreday have far more easily the government permission to enter human trials (of course even more in japan, but also South korea, china, Singapore, taiwan, usa, russia, etc)

But it will be even more bigger,cause now that they found the origin of the DNA damage (replication stress) and show an easy and cheap method to reduce it significantly, it's just a matter of days before the same team or another one in the world published the 2.0 method for 100% free DNA damage, that would lead to a big rush to enter and complete human trials from all the ones in the world who work on the iPSC hair cure

I'm sure it's already what happening now since that spanish discovery, but at more lower rate as when they will found the 100% zero genome damage method

Just a matter of days

With those major news in iPSCs and also bioengineering, IMO at least one trial will begin before the end of 2015 or beginning 2016. So 2017 would be the year for a japan temporally approval for one/some cure and 2020/22 for the definitive approval there and asian market

ps: for the septics, you have to fight against your aderans trauma life of science is exponential progress, not an infinite infernal circle

[JayM]

I hope you're right lacazette I wonder if I try to contact some of these guys and ask them what this means ect. Might say I write a blog or something :')

[Hairismylife]

Hehe how can I not be optimist when in one summer the major issues for clinical translation are being solved

With that new easy technique, many iPSC treatments will alreday have far more easily the government permission to enter human trials (of course even more in japan, but also South korea, china, Singapore, taiwan, usa, russia, etc)

But it will be even more bigger,cause now that they found the origin of the DNA damage (replication stress) and show an easy and cheap method to reduce it significantly, it's just a matter of days before the same team or another one in the world published the 2.0 method for 100% free DNA damage, that would lead to a big rush to enter and complete human trials from all the ones in the world who work on the iPSC hair cure

I'm sure it's already what happening now since that spanish discovery, but at more lower rate as when they will found the 100% zero genome damage method

Just a matter of days

With those major news in iPSCs and also bioengineering, IMO at least one trial will begin before the end of 2015 or beginning 2016. So 2017 would be the year for a japan temporally approval for one/some cure and 2020/22 for the definitive approval there and asian market

ps: for the septics, you have to fight against your aderans trauma life of science is exponential progress, not an infinite infernal circle

2017 temp approval but 2022 for full approval?
5 years time…but i know you're just speculating.
Not going to be negative but I just don't know why the DELAY always appears in hairloss world. Just see the Pilofocus, the trial was scheduled to start at July but it turned out to be a lie. Where is Wesley? Keep us waiting and waiting and their supporters tell us to be patient. Replicel still hasn't begun their phase2 trial. A delay happens even in a treatment simple as transplant, how can I be optimistic when they're playing with cells? I'm tired of hearing they've found the missing puzzle and accelarate the process and in whatever years they'll blah blah blah…is that really so funny to play with our hopes? If they can't stick to what they said please STFU!