New Topical Finasteride: Anchoring liposomes at the skin level (serum levels: 1/18th) - Page 8 - BaldTruthTalk.com
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  1. #71
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    Quote Originally Posted by Mountinvan View Post
    It is true that Trump is making it harder to get anything into US, but given the state of his hair, he might allow some topical fin. He does it orally Time for H&W to take pity on US follicularly challenged bloats.
    No http://www.nbcnews.com/health/health...dy-did-n715481 , trump is speeding FDA trials up

  2. #72
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    I called the 1-800 number on H&W's website to see if it is available in the U.S. and I was told that it was and that U.S. patients need to contact the Vancouver office and have a prescription faxed over to them, as the blog article suggested. I specifically asked if it were available to U.S. patients since the blog article suggests otherwise (but was also written almost a year ago) and the office confirmed that they do indeed handle U.S. customers. Idk I'm skeptical so I will call the Vancouver office and talk to them also. The office also claimed that they have yet to see side effects in their patients who use the liposomal solution and that the doctors themselves currently use it.

    Guys, I am really considering trying it. I think it would be cool if several of us on the forum gave it a shot and did before/after bloodwork rather than debate it so hotly. We are just trying to answer a simple question, right? Within a month of use, is there a significant impact on serum DHT and/or are any side effects experienced? If not we may continue to see if there is significant improvement in hair. If there is no change in serum DHT, then maybe that doesn't necessarily mean that finasteride has not gone systemic but I think if a change is noted, we can strongly suspect that the prostate is affected as well. It's a bit frustrating that all of the "data" shown are for a single dose or a short duration because one should fully expect tissue accumulation as this is well known about finasteride. There's a great chance that the serum levels of finasteride are only low for the first few doses so it would really be important wait long enough to reach a steady state before testing serum levels again. I often wonder if all the people studying topical finasteride deliberately avoid investigating that in order to make the product look more promising than it is. It really seems like common sense to not look at single dose data in order to formulate a conclusion about drug efficacy for chronic use.

    I think the concept makes sense. Cage the drug in a vesicle that is functionalized to become entrapped in the skin and offers diffusion resistance against finasteride, resulting in very slow release of the drug from the vesicle. If there is infinite mass transfer resistance, you can imagine that the drug can never diffuse out of the vesicle. If there is no mass transfer resistance, it goes systemic immediately like with finasteride just dissolved in a small molecule solvent. Presumable, this can be tuned. My main concern is the dose; one can also imagine that if the concentration of finasteride in the vesicle is extremely high, there is enough of a driving force for the drug to eventually make its way into the body. Thus even if the general idea of liposomal delivery can be made to work, it seems to me that it might not work if the parameters aren't appropriately tuned (for example, the liposomes do not release the drug at an appropriate rate or they do not anchor well into the skin, etc.). To that extent, I have no idea if H&W found good working conditions or not because there isn't any literature released. All I have is what the office claims and what's on the blog. Either way, I think it's worth while for a few of us to try - the worst thing that can happen is that the treatment devolves into the equivalent of taking oral finasteride. I think $70/mo is pretty reasonable if the topical really does significantly protect against systematic absorption.

  3. #73
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    It may not be too much. The liposomal formula is not intended to be adsorbed. Try it first and if you get side effects stop it. If product is made properly you should see little side effects.....for anyone who cannot get an erection because of Finasteride I found Cialis 5mg (get Canadian made generic not their other generics) solved my complaints. Just the erection part, not sperm production which may be another concern for some, but not me.

  4. #74
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    Hey guys I've just purchased some 1% and 2.5%, I was on normal propecia for a year about 6 years ago but couldn't handle the sides.. Been on Minoxidil but recently started losing a lot of ground.. So thought I try the topical, I'm just worried on the strength of the mixes I got from the Italian company. Also how do I use it? Just rub it on it doesn't state dosage or anything?

  5. #75
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    Anyway contacted hw, so the dose is what one pump provides which isn't a lot and you spread with your fingers on your scalp. Anyone else using the topical at the moment?

  6. #76
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    I hate the brain fog and impaired cognition sides from Oral Fin. Might give this a try .

  7. #77
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    Really unsure if I should post this ... but anyway:

    So for everybody who is asking about if this works (as advertised): IT WORKS!

    I am using this since day one, I was in contact with the Italian pharmacy before they even started shipping since I bugged H&W for so long till they tipped me off in an e-mail. How do I know if it works? Well, I had really really good results from fin but had to stop taking it many years ago due to side effects (gynaecomastia - if you don’t know that google it, its very common with these kind off drugs). I tried cycling the drug, I tried reducing the dose, I tried taking days off. It all did not work and in the end my body was hyper sensitive to Fin and I got sides even from a tiny amount after two or tree weeks.

    As I said, I am using this topical formulation since beginning of 2016. 0 side effects and even better results when I was on fin.

    So if you had problems with fin in the past, try it!

    Why I was hesitant of posting this? Because I recently tried to re-order and it took them over 4 weeks to ship it! They said they are super busy - then I checked this forum and someone bumped the topic ... great … that’s why …

    Anyway, I hope it helps people out there.

    Cheers

  8. #78
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    Hey appreciate the reply, I haven't started it yet as libido has been bit off so been hesitant, probably psychological due to split from the wife.. What dosage are you on 2.5%?

  9. #79
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    Quote Originally Posted by TheTruthIsBald View Post
    Really unsure if I should post this ... but anyway:

    So for everybody who is asking about if this works (as advertised): IT WORKS!

    I am using this since day one, I was in contact with the Italian pharmacy before they even started shipping since I bugged H&W for so long till they tipped me off in an e-mail. How do I know if it works? Well, I had really really good results from fin but had to stop taking it many years ago due to side effects (gynaecomastia - if you don’t know that google it, its very common with these kind off drugs). I tried cycling the drug, I tried reducing the dose, I tried taking days off. It all did not work and in the end my body was hyper sensitive to Fin and I got sides even from a tiny amount after two or tree weeks.

    As I said, I am using this topical formulation since beginning of 2016. 0 side effects and even better results when I was on fin.

    So if you had problems with fin in the past, try it!

    Why I was hesitant of posting this? Because I recently tried to re-order and it took them over 4 weeks to ship it! They said they are super busy - then I checked this forum and someone bumped the topic ... great … that’s why …

    Anyway, I hope it helps people out there.

    Cheers
    Don't want to sound rude but you only have 2 posts, and it sounds as if you were advertising this stuff...
    A non proven 50€ a month topical drug.

    You must admit it sounds rather suspicious.

  10. #80
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    It's available in Canada, but not in the U.S. It could be they didn't want to spend the
    money to get it approved in the United States.

    In "theory" .1 % topical Finasteride is supposed to be one milligram, if a gram is taken.

    We don't really know how much gets absorbed in the skin or not. If it is .25%, it should be equivalent
    to two and a half milligrams of Finasteride.

    Part of me wants to try it.

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