Sm04554

[It's2014ComeOnAlready]

Just felt like posting something about the trials, in case people missed something.

They used 3 different formulations for their phase 1 testing: 0.05%, 0.15%, and 0.45%. Participants were required to use the medication for 14 days. Anagen entry takes 7-9 days. 14 days after use (28 days since start), all hair-related measurements etc were taken.

In the phase 2 study, they recruited 300 participants, the maximum allowed for phase 2. They're also only testing at 0.15% and 0.25%. 0.45% and 0.05% were dropped, presumably because they found the most effective/safest range. The good news is, that they most likely saw an effect, because they decided not only to go through with phase 2 studies, limited the concentration range for effectiveness and safety, but they also recruited the largest group possible, at the highest cost.

We all (hopefully) now know how crucial the WNT pathway is to hair follicle formulation and cycling, so if this drug enters phase 3, get VERY excited. If anyone has any qualms about this company, keep in mind they are experts in the WNT pathway, and drugs that effect the WNT pathway. They're also trailing drugs for more serious conditions like cancer and osteoarthritis that are also WNT related. Pfizer has various agreements with this company, and have their own people working with them in R&D.

[Keki]

The first product which goes to phase 3 is our next treatment, no doubt about that, i have a good feeling about CB and SM, we could replace propecia in a couple of years

[It's2014ComeOnAlready]

I wonder, if this drug makes it to phase 3, could they have a quicker trial than usual? The medication is only used for 90 days, and they have 300 previously recruited participants. Why not trial them altogether to quicken the process?

Hopefully SM makes it there. They just finished getting all their 300 recruits for phase 2, and have pushed the end of the trial another month to October.

[runrunrun]

I always read your article cafefully. Thanks 2014 Are they(SM, CB, BIM and Replicel)feasible?? I do not want to believe fake hope any more....

[It's2014ComeOnAlready]

I always read your article cafefully. Thanks 2014 Are they(SM, CB, BIM and Replicel)feasible?? I do not want to believe fake hope any more....

Hey runrunrun, they are all feasible in their own way, all different approaches, too. SM and CB are in phase 2, and we'll know in the fall if they'll proceed to phase 3. If they do, then they will almost certainly enter the market after. For those two different approaches, it should be about 2 more years till market because they will need to get through phase 3 (approx 1 year), and then FDA approval (approx 10 months).

Bimatoprost definitely works on hair, we just don't know the results of their last trial. Hopefully the results were good enough to have them move forward, but things have been very secretive since there are legal issues with other companies making the same drug. If they've continued trials, then we should see BIM sometime in late fall or winter. They haven't updated their clinical trial page to say if they're going with a phase 3, but like I said, they could be hiding the results and maybe their current testing. Hard to know for sure, but we should find out the results of phase 2b sometime during late summer. Keep your fingers crossed.

As for Replicel, this looks like a really good treatment, and Shiseido has thrown a lot of money and research into it. They have their own shiny, new facility in Japan dedicated to this alone. Because of Japan's fast track process, they expect this will be available in Japan by 2018. So, if you have a good amount of money saved up, you could fly to Japan and have this done.

There's also Kythera's Setipiprant, which should prove very effective. That's the PGD2 hypothesis driven by Dr. Cotsarelis from UPenn. That particular drug should become available in 3-4 years.

So, there are a lot of upcoming options and new effective treatments in the very near future. All of these have a lot of research behind them. No current hair loss drug was the result of research or science, they occurred by accident. Other angles have been figured out (WNT, PGD2, PGF2a, side effect-free topical anti-androgens, cellular replacement), and are now being trialled. Nothing will come tmr or a few months from now, but there should be a lot to smile about in the next few years.

[brocktherock]

Hey runrunrun, they are all feasible in their own way, all different approaches, too. SM and CB are in phase 2, and we'll know in the fall if they'll proceed to phase 3. If they do, then they will almost certainly enter the market after. For those two different approaches, it should be about 2 more years till market because they will need to get through phase 3 (approx 1 year), and then FDA approval (approx 10 months).

Bimatoprost definitely works on hair, we just don't know the results of their last trial. Hopefully the results were good enough to have them move forward, but things have been very secretive since there are legal issues with other companies making the same drug. If they've continued trials, then we should see BIM sometime in late fall or winter. They haven't updated their clinical trial page to say if they're going with a phase 3, but like I said, they could be hiding the results and maybe their current testing. Hard to know for sure, but we should find out the results of phase 2b sometime during late summer. Keep your fingers crossed.

As for Replicel, this looks like a really good treatment, and Shiseido has thrown a lot of money and research into it. They have their own shiny, new facility in Japan dedicated to this alone. Because of Japan's fast track process, they expect this will be available in Japan by 2018. So, if you have a good amount of money saved up, you could fly to Japan and have this done.

There's also Kythera's Setipiprant, which should prove very effective. That's the PGD2 hypothesis driven by Dr. Cotsarelis from UPenn. That particular drug should become available in 3-4 years.

So, there are a lot of upcoming options and new effective treatments in the very near future. All of these have a lot of research behind them. No current hair loss drug was the result of research or science, they occurred by accident. Other angles have been figured out (WNT, PGD2, PGF2a, side effect-free topical anti-androgens, cellular replacement), and are now being trialled. Nothing will come tmr or a few months from now, but there should be a lot to smile about in the next few years.

Its good to see someone has both does their homework and is on here with the intent to help people.

[runrunrun]

Thank you for your kindness!!

[GSD]

wrong post...delete pls

[KO1]

Cots and Samumed need to put their noodles together.

[cr1mson]

Its good to see someone has both does their homework and is on here with the intent to help people.

+1 always appreciate your posts. Good to see veterans keeping it unbiased and helping newbies out.