I think I've hacked it
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I've been trying so many different things. It's a one man thing. I'm sorry, I assure you I want to do thin more than probably anyone in the world. If you want a picture though after editing it, I will update the one that I have soon. It's just basically, few black dots showing in a small area that didn't exist before. I don't think any of you will find that impressive, but those of you who are more life tech savvy will know what I'm talking about.
To let you know what I've been up to, remember the problems:
1st) It was very expensive and time consuming to make the siRNA's.
2nd) It needed daily injection so after like a week, you would develop wounds.
3rd) you needed quite a lot of material, and could develop side effects.
Right?
So I've been able to solve all of them, and soon I will try a complete trial on myself.
I'm using a way to permanently deliver genes to my head to kill Androgen Receptor, not just daily injection but once in 2 or 3 month injections. what follows is hard for lay people to understand, so that's why I don't bother updating here, because no one actually knows what I'm writing. Anyways, here is quick update:
I'm using AAV type 2 virus. It's a virus that can efficiency (100%) transfect hair follicles with the gene of interest. I've developed a vector, that has a human shRNA with in it, and it's under a specific promoter, that only get's activated in the skin.
This virus is absolutely safe. It's called Aden-associated virus. A one time injection of this genetically engineered virus will be able to knockout Androgen Receptor for more than a year, so you don't basically need to take any pills or experience side effects for a year. It also will be very cheap may be about 2000-3000 dollar each year.
Something like this, is already being sold, but for research. It's hard to explain what I'm about to do in lay terms, and I won't explain everything here as I'm starting my own biotech start-up actually.
something like this: http://www.vectorbiolabs.com/RVS/shA...n-AR-shRNA-AAV
Three things: I believe in what I do, but you guys should know that a small article you see is published takes four years. I'm just a one person doing my best. But I'm progressing very fast.Comment
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What I'm about to do, at the least will be EXTREMELY more effective than fiansteride, RU, and even the post potent anti androgens out there. You don't need to take it daily (but once a year) and it has almost zero side effects.
I'm also building my own start-up, Some very respectable people have actually offered me some money. But I have so much going on in my life. It takes time. But stay tuned. Maybe you hear a news soon in one of the newspapersComment
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Holy shit, that is impressive, I hope you will be fine and I wish you success, can't wait to hear from you again.Comment
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What I'm about to do, at the least will be EXTREMELY more effective than fiansteride, RU, and even the post potent anti androgens out there. You don't need to take it daily (but once a year) and it has almost zero side effects.
I'm also building my own start-up, Some very respectable people have actually offered me some money. But I have so much going on in my life. It takes time. But stay tuned. Maybe you hear a news soon in one of the newspapersComment
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There are still many many problems ahead.Comment
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That's where the technology I'm using comes in. My gene delivery consists of infection of genes to the scalp, and activating it later with another mechanism (chemical). That's as much information as I can give now. Also, the whole system is under a specific promoter that is only active in skin.Comment
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Also, the reason upon balding skin gets more oily and itchy, is that AR cause lineage differentiation of stem cells from hair follicle towards SG. Anyways, I've got to go.Comment
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What I'm about to do, at the least will be EXTREMELY more effective than fiansteride, RU, and even the post potent anti androgens out there. You don't need to take it daily (but once a year) and it has almost zero side effects.
I'm also building my own start-up, Some very respectable people have actually offered me some money. But I have so much going on in my life. It takes time. But stay tuned. Maybe you hear a news soon in one of the newspapersComment
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I have read papers about prostate cancer wherein AAV-mediated shRNA was used for AR knockdown
AR knockdown would be godly, like really godly.
Long term lasting 100% preventative treatment. AGA would be eradicated. One can only dream and fantasize about that dude..
But... Can you show some pictures dude? Your set-up or anything convincing, more people will take you seriously.
Putting it into practice is on a whole different level.Comment
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