New Treatment from Turkey
Collapse
X
-
-
Comment
-
I am from that turkish forum and i am not the creater or seller of that lotion. Someone posted this link on forum this morning then i came here to help about anything, not just about cellegance lotion. I have a membership with same name on turkish forum too,i am 19 and if you check you can see that i am just a regular member on there.There are not so many people who knows english so that is why i came here.
Anyway, we, "forum members" all do not know what are the ingredients of this Cellgeance lotion. Miracle, creater of lotion, sent to some of the forum members free for them to try. I think he is still working on that lotion and he says he will put this lotion in market and start to sell. He says that he set and decided the components and its rates based on scientific articles.
There arent any side effects informed by users i think, i havent checked the treads properly but they all say about smell of the lotion.It seems prety nasty. Users are all happy and pleased about the results. They all say that they see new hairs popping from the skin. They say that they hair quality and number increased.
You can all check the results from this thread. If you have any question you can ask
Comment
-
You would have to be incredibly gullible and silly to even consider some random thing like this until they show studies and proof it works other than testimony and pictures. It just feels like we have been through this kind of thing before. Some new exciting thing pops up and has little or no real evidence it works yet. Its called snake oil until proven otherwise.Comment
-
Int J Pharm. 2002 Jun 20;240(1-2):55-66.
Iontophoretic estradiol skin delivery and tritium exchange in ultradeformable liposomes.
Essa EA1, Bonner MC, Barry BW.
Author information
Abstract
This work evaluated the in vitro transdermal iontophoretic delivery of tritiated estradiol from ultradeformable liposomes compared with saturated aqueous solution (control). Effects of current density and application time on tritium exchange with water were also determined. Penetration studies used three Protocols. Protocol I involved occluded passive steady state estradiol penetration from ultradeformable liposomes and control. The effect of current densities on drug penetration rates was also assessed (Protocol II). In Protocol III, three consecutive stages of drug penetration (first passive, iontophoresis and second passive) through the same human epidermal membranes were monitored. Such an experimental design investigated the possible effect of high current density (0.8 mA/cm(2)) on skin integrity. The tritium exchange study showed that extent of exchange correlated well with current density and time of application, with some shielding of estradiol by the liposomal structure. Liposomes enhanced estradiol passive penetration after occlusion. Protocol II showed that estradiol flux increased linearly with current density, although being delivered against electroosmotic flow. In Protocol III, reduction in flux of the second passive stage to near that of the first reflected a reversibility of the structural changes induced in skin by current.
Enhanced transdermal permeability of estradiol using combination of PLGA nanoparticles system and iontophoresis.
Tomoda K1, Watanabe A, Suzuki K, Inagi T, Terada H, Makino K.
Author information
Abstract
Estradiol is a therapeutic agent for treatment of perimenopausal symptoms and osteoporosis. Conventional oral or intravenous administration of estradiol has many problems, such as, metabolization in gastrointestinal tract and liver, pain by using an injection needle, rapid increase of drug levels in blood and fast clearance with unwanted side effects including thrombosis, endometriosis and uterus carcinoma. The use of nanocarriers for transdermal delivery has been studied because of their ability to deliver therapeutic agents for long time with a controlled ratio, escaping from the first pass effect by liver. In this study, permeability of estradiol-loaded PLGA nanoparticles through rat skin was studied. Higher amount of estradiol was delivered through skin when estradiol was loaded in nanoparticles than estradiol was free molecules. Also, iontophoresis was applied to enhance the permeability of nanoparticles. When iontophoresis was applied, permeability of estradiol-loaded PLGA nanoparticles was much higher than that obtained by simple diffusion of them through skin, since they have negative surface charges. They were found to penetrate through follicles mainly. Also, enhanced permeability effect of estradiol by using nanoparticle system and iontophoresis were observed in vivo. The combination of charged nanoparticle system with iontophoresis is useful for effective transdermal delivery of therapeutic agents.
Copyright © 2012 Elsevier B.V.Comment
-
Int J Pharm. 2002 Jun 20;240(1-2):55-66.
Iontophoretic estradiol skin delivery and tritium exchange in ultradeformable liposomes.
Essa EA1, Bonner MC, Barry BW.
Author information
Abstract
This work evaluated the in vitro transdermal iontophoretic delivery of tritiated estradiol from ultradeformable liposomes compared with saturated aqueous solution (control). Effects of current density and application time on tritium exchange with water were also determined. Penetration studies used three Protocols. Protocol I involved occluded passive steady state estradiol penetration from ultradeformable liposomes and control. The effect of current densities on drug penetration rates was also assessed (Protocol II). In Protocol III, three consecutive stages of drug penetration (first passive, iontophoresis and second passive) through the same human epidermal membranes were monitored. Such an experimental design investigated the possible effect of high current density (0.8 mA/cm(2)) on skin integrity. The tritium exchange study showed that extent of exchange correlated well with current density and time of application, with some shielding of estradiol by the liposomal structure. Liposomes enhanced estradiol passive penetration after occlusion. Protocol II showed that estradiol flux increased linearly with current density, although being delivered against electroosmotic flow. In Protocol III, reduction in flux of the second passive stage to near that of the first reflected a reversibility of the structural changes induced in skin by current.
Enhanced transdermal permeability of estradiol using combination of PLGA nanoparticles system and iontophoresis.
Tomoda K1, Watanabe A, Suzuki K, Inagi T, Terada H, Makino K.
Author information
Abstract
Estradiol is a therapeutic agent for treatment of perimenopausal symptoms and osteoporosis. Conventional oral or intravenous administration of estradiol has many problems, such as, metabolization in gastrointestinal tract and liver, pain by using an injection needle, rapid increase of drug levels in blood and fast clearance with unwanted side effects including thrombosis, endometriosis and uterus carcinoma. The use of nanocarriers for transdermal delivery has been studied because of their ability to deliver therapeutic agents for long time with a controlled ratio, escaping from the first pass effect by liver. In this study, permeability of estradiol-loaded PLGA nanoparticles through rat skin was studied. Higher amount of estradiol was delivered through skin when estradiol was loaded in nanoparticles than estradiol was free molecules. Also, iontophoresis was applied to enhance the permeability of nanoparticles. When iontophoresis was applied, permeability of estradiol-loaded PLGA nanoparticles was much higher than that obtained by simple diffusion of them through skin, since they have negative surface charges. They were found to penetrate through follicles mainly. Also, enhanced permeability effect of estradiol by using nanoparticle system and iontophoresis were observed in vivo. The combination of charged nanoparticle system with iontophoresis is useful for effective transdermal delivery of therapeutic agents.
Copyright © 2012 Elsevier B.V.
Zer0. As you can tell people will always be sceptical. There is also clearly the big gap in being able to communicate. But look guys no one is trying to sell anything yet. They seem to be collecting pictures and documenting. From what I can tell the guy isn't going to sell without providing what's in the product so can we like cut the insane racism down and not scare away someone who can bridge this gap?
If he tries to sell without a lot more pictures and not saying what's in the stuff then any normal person will just leave it at that and move on. I'm even sure he would be happy to let us conduct our own trials with it.Comment
-
It just boggles my mind. As soon as anyone comes here and tries to sell this product without including what's in it and without documentation of pictures then I will be the first to lose it.
I would love to get more information about this miracle guy. Do you think there is a possible way to open communication not just with him but the well respected members of your community?
I mean I gather people look at BTT and assume it's american but really this has got to be the biggest forum for America/U.K and a good mix of European so if he ever did want to sell this is the place to come.
As a disclaimer of course it's important to point out this community is and will always be very suspicious - Including me. But if we can set up communication's then at least the "get hair or die trying people" can take the first step.Comment
-
Yeah guys, I know people will be sceptical and i am sceptical too. I have been losing my hair for 5 years. My hair loss started when i was 14 so i want more then anyone that there will be a big amazing spectecular treatment about our problem, believe me. No one will ever buy that product,including me without knowing what is in it.
So "Miracle", he did some preety good lotion by using regular drugs. We call it miracle lotion. You can all see the ingredients from this thread i think and the results. He found out and created this lotion based on researches and articles. That is why our community trust him.He always come with scientific resarches and helps us about our problem.He saved some of members hair by this mixture.Not mine though, i am still trying
So i will inform miracle about this tread and invite him here to give more information about this lotion to this community
PS: There is time difference between US and Turkey so , sorry about the delay of postsComment
-
I posted this because the turks may be able to use iontophersis method instead of their miracle lotion.... iontophersis would let them use way less estroidal than their current topical formula/method (i.e. then you get less sides).
This is also why pilox can use such small amounts of zinc and copper... because iontophesis is so good at getting molecules across the skin... it works for pilox (maybe) and it definitely worked for CB.....
so it should DEFINITELY be tried with the turks formula (estradoil)Comment
-
No mate, the link i posted is different lotion, not cellegance. We call it "miracle" lotion. We do not know about cellegance ingredients.%80 of forum members use this miracle lotion and its effective.I did try but i had side effects so i quit.Comment
Comment