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Seyed Babak Mahjour and Hongjun Wang
these two researchers will be presenting this technology at the '4th International Conference and Exhibition on Materials Science & Engineering '
September 14-16, 2015 Florida
Title: Formation of hair follicle using 3D biomimetic nanofibers constructs.
Here is a patent of 2012 from this two researchers:
'Creation of hair follicles in tissue-engineered skin grafts '
'The skin graft has dermal and epidermal layers and provides a biomimetic environment to promote healing and hair growth.
Further, a proto hair structure 82 can be observed, having a round end 84 that has the appearance of a DP aggregate. FIG. 18 is an enlarged view of the proto hair of FIG. 17, showing a partially keratinized proto hair shaft 86, similar to a hair follicle. This result shows that DP aggregates can develop into hair follicle-like structures in skin grafts.
The skin graft and method of its making are also cost-effective, in that the average cost for hair transplantation under current practices (April 2012) can be in the range of from $2,500 to $9,000 for a 5×5 cm skin graft and individual hair implantation costs of $3 to $8. In contrast, the expected cost of transplanting a 5×5 cm skin graft of the present invention, which includes hair follicles grown in the graft, would be less than about $1,000.
Here is a little pdf from them that explain their work in 2013:
"Biomimetic nanofiber enabled layer-by-layer assembly for creation of proto-hair structures"
This study was aimed to explore the possibility of
regenerating hair follicles in healed wounds by incorporating hair
follicle-like structures in TESGs. A novel and highly controllable
layering approach was developed to include pre-cultured dermal
papillae cell aggregates into the skin grafts
method:Hair follicle cells were isolated from rat and cultured in hanging
droplets to form aggregates. These aggregates were then included
between layers of the assembled 3D cell/nanofiber constructs with
dermal fibroblasts and epidermal keratinocytes. The resulting constructs
were cultured for up to 14 days.
showing L-b-L cell assembly and proto hair formation
showing hair shaft production in vivo on week 5
Conclusion
1. With the “layer-by-layer” assembly approach, skin grafts could be
rapidly fabricated within 7 days at a low cost.
2. Engineered skin grafts showed structural complexity with the presence
of dermal and epidermal compartments and proto hairs and mechanical
strength similar to the native skin.
3. These biomimetic tissue-engineered skin grafts have the potential for
treating deep wounds and serving as a suitable in vitro testing model for
cosmetic and pharmaceutical industry.
4. The ability to develop discrete architecture with multiple cell types and
proto-hair follicles in tissue-engineered skin grafts.
5. The layer-by-layer cell assembly technique, as a whole, was effective in
producing a follicle-containing constructs, allowing the hair formation in
vivo.
Nobody is in Florida in september? ^^
Those guys talk about a possible hair transplant solution in their patent so they don't forget us! The whole thing is more for burns victims at a first view( as us army and Toronto team), but in 2012 they were already showing formation of proto hair follicles, now they presenting their method in conferences, so in 3 years they surely enhanced the protocol and could have a great thing in their hand to test in clinical trial
these two researchers will be presenting this technology at the '4th International Conference and Exhibition on Materials Science & Engineering '
September 14-16, 2015 Florida
Title: Formation of hair follicle using 3D biomimetic nanofibers constructs.
Here is a patent of 2012 from this two researchers:
'Creation of hair follicles in tissue-engineered skin grafts '
'The skin graft has dermal and epidermal layers and provides a biomimetic environment to promote healing and hair growth.
Further, a proto hair structure 82 can be observed, having a round end 84 that has the appearance of a DP aggregate. FIG. 18 is an enlarged view of the proto hair of FIG. 17, showing a partially keratinized proto hair shaft 86, similar to a hair follicle. This result shows that DP aggregates can develop into hair follicle-like structures in skin grafts.
The skin graft and method of its making are also cost-effective, in that the average cost for hair transplantation under current practices (April 2012) can be in the range of from $2,500 to $9,000 for a 5×5 cm skin graft and individual hair implantation costs of $3 to $8. In contrast, the expected cost of transplanting a 5×5 cm skin graft of the present invention, which includes hair follicles grown in the graft, would be less than about $1,000.
Here is a little pdf from them that explain their work in 2013:
"Biomimetic nanofiber enabled layer-by-layer assembly for creation of proto-hair structures"
This study was aimed to explore the possibility of
regenerating hair follicles in healed wounds by incorporating hair
follicle-like structures in TESGs. A novel and highly controllable
layering approach was developed to include pre-cultured dermal
papillae cell aggregates into the skin grafts
method:Hair follicle cells were isolated from rat and cultured in hanging
droplets to form aggregates. These aggregates were then included
between layers of the assembled 3D cell/nanofiber constructs with
dermal fibroblasts and epidermal keratinocytes. The resulting constructs
were cultured for up to 14 days.
showing L-b-L cell assembly and proto hair formation
showing hair shaft production in vivo on week 5
Conclusion
1. With the “layer-by-layer” assembly approach, skin grafts could be
rapidly fabricated within 7 days at a low cost.
2. Engineered skin grafts showed structural complexity with the presence
of dermal and epidermal compartments and proto hairs and mechanical
strength similar to the native skin.
3. These biomimetic tissue-engineered skin grafts have the potential for
treating deep wounds and serving as a suitable in vitro testing model for
cosmetic and pharmaceutical industry.
4. The ability to develop discrete architecture with multiple cell types and
proto-hair follicles in tissue-engineered skin grafts.
5. The layer-by-layer cell assembly technique, as a whole, was effective in
producing a follicle-containing constructs, allowing the hair formation in
vivo.
Nobody is in Florida in september? ^^
Those guys talk about a possible hair transplant solution in their patent so they don't forget us! The whole thing is more for burns victims at a first view( as us army and Toronto team), but in 2012 they were already showing formation of proto hair follicles, now they presenting their method in conferences, so in 3 years they surely enhanced the protocol and could have a great thing in their hand to test in clinical trial
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