CB-03-01 - new antiandrogenic

[BaldingJugZ]

Anyone ever heard of a supposed new anti-androgenic drug called CB-03-01?

I've looked into it and read a few threads on the subject.

Apparently, it is still in the next phase of testing. However, there is a few Chinese labs producing it at a hefty price.

So, was just wondering if anyone has bought it from China and how they went about getting it into a topical solution? (as it's in crystal form)

Any thoughts on it?

[mlao]

At this stage I think it's a bad idea. All those guys on *** and HLH never post a lot of pictures of their success on things like RU58841. Now they are trying to go in on a group buy for CB-03-01 from the same labs that they buy the RU from.
Don't get me wrong I hope it works and they show great results but even Cosmos the company that owns the patent and is doing the clinical trials hasn't released any photo evidence of results. Nor is there an established method on how to use it. I would wait.

[Kirby_]

Update from Cosmo.

http://www.cosmopharma.com/~/media/Files/C/Cosmo-Pharmaceuticals/ir/presentations/25-01-2013/RDDAY_25JAN13_v5.pdf

[Thinning87]

very interesting, this would be a topical application and wouldn't affect the 5 alpha reductase, in that way causing less side effects (correct me if I'm wrong)

[NotBelievingIt]

very interesting, this would be a topical application and wouldn't affect the 5 alpha reductase, in that way causing less side effects (correct me if I'm wrong)

Nope, you read that correctly. What it reads like it does is binds to the androgen receptors in hair follicile where it is applied, thereby basically taking the place of DHT on the hair follicile.

Fin/Dut bind with 5AR and prevent that enzyme from converting T to DHT, hence side effects. This basically does the same thing, but bypasses the hormone altering.

Who knows what side effects it might have. Your hair might stop falling out, but it might degrade hair quality if active androgen receptors are decreased, thereby decreasing potential protein uptake....

Something interesting to follow.

[Thinning87]

yeah, or virtually this may be a cure in the sense that if it doesn't have side effects it would pretty much save all the hair or highly slow down MPB.

I see some people were getting some shipped from China, these people are in very early stages of development so I definitely wouldn't try it!

[burtandernie]

Interesting for all the different timelines people say their projection is early 2015 to be on the market if all goes well. Also for all the talk about vehicles they mention the vehicle they are looking at for the 5% cream.
Nothing is ever certain with this stuff, but I doubt the androgen receptors interact with proteins uptake. They say this chemical gets converted into a natural substance in the blood stream so it seems like sides will be pretty minimal, but again its unpredictable in nature given how complicated this all is.

[Kiwi]

At this stage I think it's a bad idea. All those guys on *** and HLH never post a lot of pictures of their success on things like RU58841. Now they are trying to go in on a group buy for CB-03-01 from the same labs that they buy the RU from.
Don't get me wrong I hope it works and they show great results but even Cosmos the company that owns the patent and is doing the clinical trials hasn't released any photo evidence of results. Nor is there an established method on how to use it. I would wait.

Except people are posting pictures of RU results...

[Pate]

Good find thanks Kirby... I saw that R&D day was coming up, I was hoping they'd release a presentation with it.

New info: they FINALLY named the CB partner - Medicis, now Valeant. Never heard of them, time for some research.

On the basis of skin permeation test results and of stability test results,
CB-03-01 5% anhydrous solution was selected as the candidate drug
product for the treatment of alopecia.

They have a vehicle for alopecia!!! Excellent news. Anhydrous, which could mean just about anything.

Interesting that they went with the 5% solution even though their POC study indicated there was no significant difference between the 1% and 5% formulation.

March 2014 target for end of Phase II for acne.

For alopecia, March 2015 is end of POC study. From what I can tell "Proof of Concept" clinical trials encompass Phase I and Phase IIa.

That's a bit disappointing. It will be at least 2017 before CB comes out for alopecia. But at least they have a clear path to commercialisation.

[burtandernie]

Oh I thought since the slides ended at 2015 that is the date it came out. Really not until 2017? Good lord I better go see a derm and get on finasteride or I will never have hair left by then 2017 is a long long time.
If this comes out and is on the shelf next to rogain with minor sides I see this selling a ton and becoming the gold standard. Heck it will answer questions on if stopping T and DHT at the receptor can stop MPB or not and how T affects hair growth for say facial hair or unwanted body hair. It might stop MPB completely forever I mean who really knows.

[lilpauly]

cb-03-01 is easy to get! its the dam vehicle thats the problem. when i bought cb-03-01 from finfighter it was 340 per gram noe we can get for 150 per gram or cheaper. we trying to find the best possible vehicle for cb

[Knockin on NW4]

cb-03-01 is easy to get! its the dam vehicle thats the problem. when i bought cb-03-01 from finfighter it was 340 per gram noe we can get for 150 per gram or cheaper. we trying to find the best possible vehicle for cb

And we have PICS of a member who used cb + minox for a whole year, he has had good regrowth using a cream vehicle at 1% . PM lilpauly aka mark if u want to join our community and get in on our Group Buys. We can get CB for $105 per g if we get a large enough order. Everything gets tested. 1 gram will last 100 days @ 1% in a 1ml application. 2% would even be affordable at $105 per gram. We can get any research chem. SABA Gel, vitamin D analogue, RU, ect. We are even working on getting BNP and CNP, plus a HSC alternative. We have a super organized forum with full text libraries on the latest hairloss advancements (not misleading abstracts and bro science). There are no fees, nor requirements to buy products, just rules and etiquette to keep us sufferers civilized. PM Lilpauly, you will regret not joining us.

[Troy]

And we have PICS of a member who used cb + minox for a whole year, he has had good regrowth using a cream vehicle at 1% . PM lilpauly aka mark if u want to join our community and get in on our Group Buys. We can get CB for $105 per g if we get a large enough order. Everything gets tested. 1 gram will last 100 days @ 1% in a 1ml application. 2% would even be affordable at $105 per gram. We can get any research chem. SABA Gel, vitamin D analogue, RU, ect. We are even working on getting BNP and CNP, plus a HSC alternative. We have a super organized forum with full text libraries on the latest hairloss advancements (not misleading abstracts and bro science). There are no fees, nor requirements to buy products, just rules and etiquette to keep us sufferers civilized. PM Lilpauly, you will regret not joining us.

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This community has made me change the way i see the future of hair loss treatments...everything seems to be closer now...

Together we are stronger...as the community evolves, as more people that really try to be proactive about this "disease" join, more possibilities and more effective treatments we achieve!

This community has given us the possibility to better understand other possible treatments, while also given us the possibility to use some of them in the correct way...

As the community grows more and better treatments will be within our reach...

As knockin said if you are interested in get more knowledge about other treatments or be able to get them...contact someone from the community (like lilpauly / marklc2004)

[clandestine]

Knockin; How is PSI fairing for you? Anything notable since the last update?

[Knockin on NW4]

Knockin; How is PSI fairing for you? Anything notable since the last update?

My Labpe sponsored trial of preloaded resin PSI is freely discussed @ PHG! anyone who wishes to see my results and discussion, please join our community. Dont let paranoia prevent you from expanding your hairloss knowledge and resources. Labpe supplied me with free psi. Why would any supplier do this if they were scamming? Most research chems are so expensive, people drop them in 2 months, then give negative feedback. Hairloss is one tough cookie. At PHG we dip that bitch in milk. PM Mark.