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  1. #541
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    Ah feck it anyway. Ken Washenik is probably telling porkies. Here's the timeline copied from the link below.

    http://tressless.com/learn/Hair_Multiplication

    •1941 Lillie and Wang demonstrate new feathers can be created by implanting dermal papillae in the skin. (Note: feather follicles and hair follicles are extremely similar.)

    •1954 Breedis shows, under certain conditions, after complete destruction or removal of hair follicles in adult mammals, new follicles can grow in the skin.

    •1956 Montagna & Chase purposely damage follicles by X-radiating the scalp. Remaining dermal papilla and ORS cells repair and regrow the hair follicles.

    •1961 Cohen pioneers the use of large rat vibrissa follicles to isolate dermal and epidermal follicular components for transplantation experiments. He demonstrates implanted dermal papillae are capable of producing new follicles in the skin.

    •1966 Oliver shows DP cells are responsible for regenerating new end bulbs in amputated follicles.

    •1981 Oliver and Jahoda culture rat DP cells and show implanting them in wounded rat skin results in follicles that produce hair fiber resembling that of DP cell's host follicle.

    •1984 Messenger shows cultured human DP cells behave in vitro very similarly to cultured rat vibrissa DP cells.

    •1992 Jahoda and Reynolds demonstrate cultured dermal papilla cell induction of hair in glabrous skin (rat foot pad)

    •1993 Jahoda reveals he has been successful growing new follicles in humans using cultured human DP cells. No research papers are forthcoming.

    •1996 Cooley cultures his DP cells and implants them into is arm. One new hair grows as a result. The hair is later shed.

    •1996 Yoshizato et al demonstrate long-term culture of hair inductive dermal papilla cells

    •1997 Gho begins hair multiplication experiments. After discovering DP cells have extreme limitations, he begins using ORS and stem cells extracted from plucked hair to rejuvenate shrunken MPB human follicles.

    •1999 Jahoda implants his intact dermal sheath in wife's arm and grows hair. However, he discovers his cultured DP cells fail to result in hair growth.

    •1999 Intercytex is formed. Paul Kemp is Chief Scientific Officer.

    •2001 Barrows of BioAmide presents paper documenting having grown hair in a human patient using cultured DP cells.

    •2001 Gho states he’s aiming to introduce HM within 5 years.

    •2002 Aderans Research Institute is formed. Notable hair scientist Kurt Stenn is recruited as Chief Scientific Officer. BioAmide is purchased as basis of research and Barrows is taken aboard. Washenik says he thinks it will take 5 years to have a commercially available product.

    •2002 Kemp announces in best case scenario product submission could be as early as 2005.

    •2003 Washenik says it will take 5 more years to release a product. Onlookers wonder why cure is always 5 more years away.

    •2003 Intercytex begins phase I trials in England.

    •2005 Gho continues to struggle with growing hair consistently in his human test patients. He cannot figure out why some patients respond well to the treatment and others barely respond at all. Many baldness sufferers shift hopes to Intercytex.

    •2005 Intercytex completes phase I studies well behind schedule. Results appear promising. 5 of 7 patients grow hair. Kemp grows 66 new hairs from 100 injections and refers to it as an average response to treatment.

    •2006 Gho misses 5-year prediction.

    •2006 Intercytex begins phase II studies in England.

    •2007 Aderans begins phase I studies in England. Interestingly, they use a two-cell approach compared to Intercytex’ one-cell approach.

    •2008 Intercytex announces it will cease financing the development of ICX-TRC after completion of phase II completes and attempt to find a partner to finish the research and distribute the product. Many see this as a sign of product ineffectiveness. On the bright side, all patients who received pre-stimulation of the epidermis had increased hair counts. HM works in everybody. The question is, how well it works?

    •2009 Aderans launched Phase II trials (April 24, 2009). Phase II of the study is being conducted in six U.S. cities: Atlanta, Boston, New York, Raleigh, Houston, and Washington DC. Currently phase II trials are taking place and it’s expected to be completed by the end of 2009. Talking about the avaliability of the HM i have heard that within 5 years. If we look back here to 2003 then Washenik told that after 5 years (2008) but now is already september 2009 and they still need 5 more years. Timline is moving and we don't know exactly when they can bring this cure to market. Hopefully by the end of 2009 we have more information about their phase 2 studies.

    •2009 TrichoScience started human hair cloning clinical trials (Phase I) in Europe September 2009. It's interesting that we can see from their website the cost of the cure for the patient which is approx $16,500 - $29,500

    •2009 Intercytex closes its doors.

    •2010 Researchers Develop First Successful Hair Cloning Technique (with MatriStem® MicroMatrix(regenerative medicine by Acell) by Gary Hitzig, M.D. and Jerry Cooley )

    •2010 Aderans Research Treats One-Hundredth Subject in Clinical Study. Aderans Research Institute Inc. (ARI) recently (February 28, 2010) achieved a significant milestone in its Phase 2 clinical study of cell-based hair regeneration, treating the trial’s 100th subject. With clinical sites expected to double in the coming months, the study will likely add dozens of additional subjects to its enrollment.

    •2010 Aderans Research Institute Inc. (ARI) said today (May 4, 2010) it has expanded its clinical trials on hair regeneration by an additional seven cities in the United States. Las Vegas, NV; Los Angeles, CA; and New Hyde Park, NY, have been added through clinical site company Impact Clinical Trials. Tucson, AZ; St. Louis, MO; Birmingham, AL; and St. Petersburg, FL, have been added through clinical site company Radiant Research. Collectively, the Radiant and Impact sites will add around 80 new subjects to the study. Combined with at least twenty new additions at a site hosted by TKL Research, the second phase of ARI’s clinical study will surpass 200 subjects in total, a remarkable number of participants for a Phase 2 trial.


    So back in 2002, Ken Washenik said 5 years. Then again in 2003. Then in 2009 they said 5 years. Here's how the next interview goes with Spencer:

    Spencer: So what progress have you guys made? I hear you're coming to the end of phase 2? Any chance we'll see a product out in 2014 to meet the timeline?

    Ken: Yeah about that...ah...We're still modifying the process for optimal results so we're going to run another 4 protocols so we're probably looking at midway through 2016 before we've got a workable treatment to bring to market.

    Spencer: So the FDA process will be complete by 2016.

    Ken: Well we'll have a product that could go to market but we'll have to go actually go through phase 3 to get FDA approval.

    Spencer: How long will that take?

    Ken: 2020...ish

    Spencer 2020ish?

    Ken: Then we have to train in the Bosley team so it's more likely that it will be 2022.

  2. #542
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    11 more years wtf! Shoot me now. Basically aderans is for my grand-kids then.

  3. #543
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    Quote Originally Posted by CAlex View Post
    11 more years wtf! Shoot me now. Basically aderans is for my grand-kids then.
    Hell I don't know. One thing though, these things always take longer than anticipated. Just the way it is I guess. If it doesn't happen in time for me personally I'm ok with that as long as it does come along eventually to help all those that probably have no idea yet that hair loss is going to creep up on them. I sometimes get caught up in all this optimism but I suppose 2022 is more reasonable than 2014. If it came in 2017/2018 I think they'd be doing very well in all honesty. I know last year they said 2014 but Ken Washenik has done some presentations this year and he's just said "in the future" this will be a new non invasive form of HT. Who really knows, we're just pulling dates out of the air here.

    Let's face it, Aderans can give many some more density but it's not going to reverse a norwood 6 or 7 back to a strong 2. Not in the early running anyway. I see it as an adjunct to traditional HTs. A density top up if you will. If it could give us an extra 25FU/cm2 we'd be laughing. Let the big 3 serve as a bridge to something better. Maybe PRP+Acell injections will be proven to work but I'm not so sure. Possibly retard loss I think.

    I'm still convinced that the synergistic effect of multiple treatments will be the way to go initially when this thing lands. Ideally if Acell provides the 54% donor regrowth from FUE that Dr. Cole is claiming, then FUE+Acell combined with Aderans can give you some pretty damn good density. As Aderans get's cheaper you could always top up the density over time. I hope FUE before Aderans doesn't affect growth in from the injected stem cells. If I had to guess I'd imagine that Aderans would work better on a virgin scalp. But then again that's just conjecture.

  4. #544
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    Quote Originally Posted by Follicle Death Row View Post
    Well it's going to happen eventually. You're right not to get too optimistic though. This is all just conjecture until it actually arrives. Phase 2 results from both Histogen and Aderans will tell us where we're really at. Until then it's just a guessing game I suppose. In 2 years those phase 2 results will be out and then we can truly evaluate where we're at with this whole thing.
    I agree. When Histogen, Aderans, and TrichoScience/RelpiCel release their results, and when Drs. Bernstein and Cooley share theirs (regarding ACell) — all of which, I believe, are to happen by the end of 2012 — we should have a sense of where we are. In the meantime, I expect some more bull-shit will come around — pills, elixers, and the such — but, unless it's from a reputable source, I think I'll try to curb my enthusiasm.

  5. #545
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    Quote Originally Posted by HairTalk View Post
    I agree. When Histogen, Aderans, and TrichoScience/RelpiCel release their results, and when Drs. Bernstein and Cooley share theirs (regarding ACell) — all of which, I believe, are to happen by the end of 2012 — we should have a sense of where we are. In the meantime, I expect some more bull-shit will come around — pills, elixers, and the such — but, unless it's from a reputable source, I think I'll try to curb my enthusiasm.
    I'm with you on this. End of 2012, like December 21st or something lol. But yeah end of 2012 we should know. Plenty of bullshit between now and then though.

  6. #546
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    These threads will make any balding man go crazy.

    I can not post in here every day for my own sake, yet I torture myself and read all the comments and all the "10 years away", "2 years away", "5 billion light years away".

  7. #547
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    I almost don't even care about all this Histogen/Aderans talk. It's obviously not happening any time soon. I'm more interested in Acell, which does seem to be happening soon.

  8. #548
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    Quote Originally Posted by Flowers View Post
    I almost don't even care about all this Histogen/Aderans talk. It's obviously not happening any time soon. I'm more interested in Acell, which does seem to be happening soon.
    Acell is surgical right?

  9. #549
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    film

    I haven't even been in this forum a year but quickly noticed how people change opinions daily. It is frustrating and you don't even know what to think. What's funny is that no matter what people say, whether it's 5 or 20 years away, we all live in this ****ing forum.

  10. #550
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    I think the most important question now is how effective these treatments will be.

    To be honest, if they were real "cures" I would not mind to wait 5 or 10 years for them to come true.

    The problem is that we do not know if they are gonna be better than minoxidil with propecia. So far it seems that for some they might not to be, if they do not compound.

    Efficiancy is imho most important. Once they have something that works and is better than minox and propecia or HTs then time doesnt rly matter much. Once it works well, the investors will do anything and everything to make sure it will be on the market in less than 5 years imho.

    But are histogen or aderans rly better than propecia? Aderans first protocol in phase 2 seems to be on par with propecia results for 40-50 or more percent of ppl atm but other half would be better on propecia. Histogen? Who knows how that compares.

    And most importantly. Do multiple treatments compound? We dont know yet. They may or well may not.

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