Hasson & Wong now prescribing topical Finasteride

[lilpauly]

clinical data proves its just as good as taking 1 mg

[hdude46]

Where are you getting this info?

[FearTheLoss]

I know they are prescribing topical fin, but I didn't hear anything about it being as good as one 1mg other than a small study.

[the_dude78]

I found this:

"Pharmacodynamic of P-3074 (finasteride 0.25% topical solution) in subjects with androgenetic alopecia
M Caserini1, R Palmieri1, M Radicioni2 and E Terragni2 1Polichem S.A., Lugano, Switzerland and 2Cross Research S.A., Arzo, Switzerland
A new proprietary topical formulation, P-3074, containing finasteride 0.25% as active ingredient and hydroxypropyl-chitosan (HPCH) as film-forming agent, was developed for androgenetic alopecia. The present study was aimed at investigating the pharmacodynamic profile of finasteride in terms of dihydrotestosterone (DHT) concentrations in the scalp and in serum after multiple topical application of P-3074 or oral finasteride intake in subjects with androgenetic alopecia. Eighteen healthy men were randomly allocated to P-3074 or oral treatment after providing written informed consent. Twelve volunteers applied P-3074 topical solution for 7 days: six subjects once daily (o.d.) in the morning and the others twice daily (b.i.d.) in the morning and in the evening. The third group of six volunteers was administered 1 mg oral finasteride once daily in the morning for 1 week. Scalp (vertex) biopsies were collected at baseline and 6 hours after last dose administration, while serum samples were collected at baseline, before last administration, and 6 and 12 hours after the last multiple dose. A marked decrease in scalp DHT levels was observed: by 47.22% with P-3074 b.i.d., from 1.91 (±0.54) to 1.01 ng ml−1 (±0.39), by 71.20% with P-3074 o.d., from 1.52 (±0.41) to 0.44 ng ml−1 (±0.08), and by 51.11% with the oral formulation, from 1.39 (±0.25) to 0.68 ng ml−1 (±0.34). Serum DHT was reduced by 69.3–74.0% with P-3074 b.i.d., 67.6–80.4% with P-3074 o.d., and 69.7–76.1% with the oral formulation. These results showed a similar inhibition of serum DHT after 1 week of finasteride administration with the three dose regimens and were consistent with the results obtained in a previous P-3074 PK study. These findings show that DHT concentration in the scalp, after 7-day treatment course of P-3074 o.d., was more reduced (about 40%) than after 1 mg oral finasteride administration for the same treatment period."

Source: http://www.nature.com/jid/journal/v1...d2013110a.html

[the_dude78]

If this becomes available in EU, I will definitely try it out.

[FearTheLoss]

You have to go to them to see it. They are having a local pharmacy make it for their patients who cannot tolerate oral fin, I believe. I'm going to pay a visit to them within the coming months to obtain some.

[hellouser]

If this becomes available in EU, I will definitely try it out.

If the vehicle is known, you could probably do it now.

[efedrez]

Do we know anything about sides with topical? it sounds like good news unless chances of going systemic are also high and same horrible sides

[Jazz1]

You guys are jokers, genhair was way ahead of the game with their topical formula that worked, it all ends up going back into the bloody stream like 1mg FIN, personally nothing beats internal results.

[burtandernie]

Yeah it might just end up going internal anyways. Thats why something like CB with a different chemical structure is the only way a topical might work. I still have high hopes CB might be the first real topical with little sides.