PGD2 causes hair loss according to Dr. Cotsarelis

**kaandereli** · 03-21-2012, 03:57 PM

no mention about dht.so we are dumping the dht thesis?
or maybe we will combine finasteride with the new drug

**Mojo Risin** · 03-21-2012, 04:18 PM

My trolling friend strikes again.

Guess who's behind a treatment ? Merck.

Love this industry.

**Scoots** · 03-21-2012, 05:41 PM

Here's an interview from Cotsarelis on the recent discovery. I don't want to get my hopes up too quickly, but if these medications in phase 3 could work in a topical solution like he predicts might be possible...it would be like a miracle out of nowhere.

Research identifies inhibitor causing male pattern baldness and target for hair-loss treatments

http://medicalxpress.com/news/2012-03-inhibitor-male-pattern-baldness-hair-loss.html

Researchers from the Perelman School of Medicine at the University of Pennsylvania have identified an abnormal amount a protein called Prostaglandin D2 in the bald scalp of men with male pattern baldness, a discovery that may lead directly to new treatments for the most common cause of hair loss in men. In both human and animal models, researchers found that a prostaglandin known as PGD2 and its derivative, 15-dPGJ2, inhibit hair growth. The PGD2-related inhibition occurred through a receptor called GPR44, which is a promising therapeutic target for androgenetic alopecia in both men and women with hair loss and thinning. The study is published in Science Translational Medicine.

**Mojo Risin** · 03-21-2012, 05:49 PM

''It'll take a while to figure out but we'll have to partner with a company to generate more research funding so we can answer that question.''

Typical Cotsarelis.

**clandestine** · 03-21-2012, 05:50 PM

May, might, maybe; Meh.

**Kirby_** · 03-21-2012, 06:53 PM

Originally posted by kaandereli

no mention about dht.so we are dumping the dht thesis?

IIRC, it's known that DHT is involved in causing MPB, somehow, rather than known to be specifically the trigger for it. If that makes sense.

**Maradona** · 03-21-2012, 07:08 PM

Originally posted by Kirby_

IIRC, it's known that DHT is involved in causing MPB, somehow, rather than known to be specifically the trigger for it. If that makes sense.

if this works you won't even have to wait for the product...after the release the details of their studies people will find a way to make their own solutions like in ************.

hopefully it buy us some time.

edit: hair loss talk is a bad word lol.

**Smega** · 03-21-2012, 07:56 PM

Was going to post this story. Check it out here too:

MSN

http://health.msn.com/health-topics/skin-and-hair/articlepage.aspx?cp-documentid=100288313

**jgold** · 03-21-2012, 09:33 PM

im so happy that they found this out. SO MUCH MORE POTENTIAL NOW

**Gubter_87** · 03-21-2012, 11:49 PM

This does not in any way exclude DHT from the picture - as hormones are involved in regulating genexpression. It could very well be DHT that regulates PGD2 synthesis in the follicles that are prone to MPB.

**Mojo Risin** · 03-22-2012, 12:51 AM

This won't give hair back to a Norwood 7.

Just a minoxidil on steroids.

**Gubter_87** · 03-22-2012, 03:14 AM

Mojo: What makes you say that?

Truth is we have no idea what significance this will have today. If the hair follicles are actively inhibited by PGD2, and we are able to inhibit that inhibition - then there is no saying if the hair will grow back or not.
It could give a NW7 a full head of hair, and just as well it could be of minimal significance to hair loss.

There is no logic in comparing this to minoxidil, which stimulated potassium channels. They have nothing in common.

**Mojo Risin** · 03-22-2012, 03:30 AM

Maybe you should read this : http://health.msn.com/health-topics/...ntid=100288313

And Dr. Sanusi Umar version of the story.

Come on guys, are you really going to fall into Cotsarelis trap again ? Isn't it obvious enough that the guy is just seaking easy fundings ? Seriously we're more intelligent than that, I'm not buying into Cotsarelis BS again. The guy comes out every year or so with a new piece of the puzzle ...

He comes up with a new hypothesis every year or so ... it gets so redundant. I just have no reason to trust this guy honesty anymore.

Couple weeks ago, someone tried to get Cotsarelis in an interview to talk about Follica ... and he refused. And now all of a sudden, he's all over the media. Come on ...

**Pate** · 03-22-2012, 03:42 AM

Originally posted by Gubter_87

There is no logic in comparing this to minoxidil, which stimulated potassium channels. They have nothing in common.

Actually they have a lot in common, namely the fact they act on prostaglandins. We know the potassium channels aren't the cause of hair growth in minox because other K channel drugs and other vasodilators have no hair growth effects. It is thought that minox regrows (some) hair because... surprise surprise, it stimulates a certain prostaglandin. Latisse stimulates another one. This discovery is about inhibiting a third.

I think this is fascinating. No immediate joy for hair loss sufferers, even these asthma drugs in Phase III will need to go back through clinical trials for hair loss. The only real benefit is probably that they won't have to do the pre-clinical toxicology research etc, plus there will be less red tape with the FDA.

But Cotsarelis is doing some amazing work. This led directly from his discovery about the inactivated stem cells. They figured something be preventing the activation of the stem cells so they went out and looked for it, and in a pretty short space of time found something.

It just sucks this work isn't likely to lead to viable treatments in time for most of us.

PGD2 causes hair loss according to Dr. Cotsarelis

PGD2 causes hair loss according to Dr. Cotsarelis

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