Any comment on this theory?
I just read a thread in *** forum about MPB. That bro says hair follicle can be enlarged again in a suitable enviroment. He says hair follicles are prevented from re-enlargement by 2 main issue: fluid pressure and fibrosis around. Maybe I have misleading presentation in just few sentences so please have a look on the long thread posted by S.Foote. Maybe a cure is there.
Electric current-induced lymphatic activation.
Abstract
The lymphatic system in skin plays important roles in drainage of wastes and in the afferent phase of immune response. We previously showed that activation of vascular endothelial growth factor receptor (VEGFR), specifically the VEGFC/VEGFR-3 pathway, attenuates oedema and inflammation by promoting lymphangiogenesis, suggesting a protective role of lymphatic vessels against skin inflammation. However, it remains unknown how physical stimuli promote lymphatic function. Here, we show that lymphatic endothelial cells (LECs) are activated by direct-current (DC) electrical stimulation, which induced extension of actin filaments of LECs, increased calcium influx into LECs, and increased phosphorylation of p38 mitogen-activated protein kinase (MAPK). An inhibitor of focal adhesion kinase, which plays a role in cellular adhesion and motility, diminished the DC-induced extension of F-actin and abrogated p38 phosphorylation. Time-lapse imaging revealed that pulsed-DC stimulation promoted proliferation and migration of LECs. Overall, these results indicate that electro-stimulation activates lymphatic function by activating p38 MAPK.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Could you post this for S. foote to see?