Replicel

The video was pretty interesting. I think their process might be the one. If the trials go as well or better than planned maybe 2013 or 2014 will be the year it's released. I bet this process costs $10,000 at least.

I don't care if it costs an arm or a leg.

As long as the results are there, I'll find a way to finance it.

Cost was never an issue. If this process works (which doesn't leave scars all over your head), I would even pay $20,000. Having my hair back is absolutely priceless for me. I believe that there are so many people out there like myself who would pay anything to get their hair back, but they don't want their head permanently scarred for life.

It's my understanding that conventional hair transplants are expensive due to the fact that the procedure requires a significant number of man-hours by technicians trained in microsurgery. This technique seems fundamentally simpler less labour intensive, which could mean hair restoration doctors could charge less, lower the treatment price and treat more patients to gain an overall increase in revenue.

I know this is slightly off topic but does anyone know anything about the PRP doctor in Canada offering treatment? They have pics on their site and say it's $600 per treatment and you go 3 months after your first treatment and then possibly once a year for maintenance. Check it out at the PRP thread under the histogen thing on the top of the threads. Sounds interesting but I'm skeptical

Wait, replicel is what TrichoScience used to be, right? When did they say it'sgoing to come on the market?

Quote:

---

Originally Posted by Dutch_Dude

Wait, replicel is what TrichoScience used to be, right? When did they say it'sgoing to come on the market?

---

If everything goes as planned, they might be out before anyone. They are not going through FDA. They can come out as soon as 2013-14!

so what are replicel planning on doing just doing 2 clinical trials and offering it outside the us.. Lik canada or something.

Quote:

---

Originally Posted by CVAZBAR

If everything goes as planned, they might be out before anyone. They are not going through FDA. They can come out as soon as 2013-14!

---

That seems early, do you think they are able to release it that soon with good results...or do we have to wait for later generations?

I'm actually really excited about Replicel, because their solution is planned to be a real cure. That's at least the way I have been informed about them. Hope it's gonna work out :)

Quote:

---

Originally Posted by BoSox

That seems early, do you think they are able to release it that soon with good results...or do we have to wait for later generations?

---

Well I also think it's real early but based on their testing timeline it's a possibility. I personally not expecting it to be that early but I think I remember reading they would be done with trials around late 2013. Maybe I'm wrong but I also remember that being brought up in the TBT show. Maybe someone can verify that.

Are they all really aiming for 2014 or do they just have to say 2014 to get investors, especially as company x and company y are aiming for 2014. If we knew for sure there would be a good solution by 2014 many of us could rest a little better. They all sound overly optimistic to me. I could understand if Aderans had a product available by 2014 as they've been at this for ages.

Quote:

---

Originally Posted by Follicle Death Row

Are they all really aiming for 2014 or do they just have to say 2014 to get investors, especially as company x and company y are aiming for 2014. If we knew for sure there would be a good solution by 2014 many of us could rest a little better. They all sound overly optimistic to me. I could understand if Aderans had a product available by 2014 as they've been at this for ages.

---

I know... Ive been following Aderans since 2004.

Someone kill me.

Quote:

---

Originally Posted by CVAZBAR

If everything goes as planned, they might be out before anyone. They are not going through FDA. They can come out as soon as 2013-14!

---

Is not going through the FDA necessarily a good thing? I know the FDA isn't popular around here but the list of products that haven't gone through the FDA is not a list I would want to be on. Also, is there a reason that the Histogen thread is getting a lot more activity? Seems like Replicel is just as likely to work according to their theory.

Quote:

---

Originally Posted by Bronson

Is not going through the FDA necessarily a good thing? I know the FDA isn't popular around here but the list of products that haven't gone through the FDA is not a list I would want to be on. Also, is there a reason that the Histogen thread is getting a lot more activity? Seems like Replicel is just as likely to work according to their theory.

---

Getting an approval from the FDA isn't really worth anything these days. They are more famous for their incompetence and corruption than their dedication and moral convictions.

As far as Histogen getting more attention it's simply a matter of Histogen having actually proven that they can grow hair on human scalp. Replicel is for the time being an unproven theory. It does have very sound research behind it and animal studies suggest that it will be an effective treatment for human hair loss but it still remains to be proven in clinical trials.

I have to agree, Histogen provided some tangible results in the pre-clinical with humans, whilst replicel are yet to produce any human results.

Quote:

---

Originally Posted by Losing_It

I have to agree, Histogen provided some tangible results in the pre-clinical with humans, whilst replicel are yet to produce any human results.

---

so did renokin

Quote:

---

Originally Posted by NeedHairASAP

so did renokin

---

I don't know Renokin, but I think you may be comparing apple to oranges

I too do not trust the FDA and entities like that. I mean it can be useful as far as side effects go, but I fear that they are there to look out for the interests of big pharmaceutical companies.

Quote:

---

Originally Posted by Losing_It

I don't know Renokin, but I think you may be comparing apple to oranges

---

lol so true.

Quote:

---

Originally Posted by Bronson

Is not going through the FDA necessarily a good thing? I know the FDA isn't popular around here but the list of products that haven't gone through the FDA is not a list I would want to be on. Also, is there a reason that the Histogen thread is getting a lot more activity? Seems like Replicel is just as likely to work according to their theory.

---

If I'm correct, I believe everything is derived from human body. This does not require FDA strict trials. It's not a drug. The setbacks would come from efficacy I guess.

that's settled then :). it's weird that they are doing it in georgia...i mean...no offense haha...i didn't expect georgia to be the scientific center of replicel :P.

anyways...too bad they don't have photos...

Well of course they don't have photos, they just begun clinical trials, which in their case means one treatment session and then they invite the patients back 6 months later to evaluate the results.

I think they're doing it in Georgia for the same reason Histogen is doing it in Singapore; Some countries have loose regulations and restrictions which makes it faster and easier to conduct scientific research and clinical trials there.

All the better for us then. Replicel is going to work I feel. As for when they'll perfect it and get it out to us is anyone's guess. I do have one problem with the procedure outlined: Why take a 4mm diameter punch? Could they not get the DSC from taking perhaps 4 1mm diameter punches. I'd rather have a few small dots than a little button scar. I'm getting way ahead of myself here. :D

The country of Georgia is actually trying to promote itself as something of a medical tourism destination where people can get cutting edge treatments before they become available elsewhere. I wonder if Replicel might be released in Georgia following initial trials before it is released in other parts of the world

I think we need an interview with Replicel!!!! It's been a while since we've had another. We need a Histogen, Lauster, Aderans, Follica ANYTHING new. It's been a while.

i didn't know that about georgia. cool. we definately need an interview...sounds very promising.

New videos from Replicel!

The Science behind Replicel :
https://www.youtube.com/watch?v=0tHDKT7uZp4

Replicel's Vision :
https://www.youtube.com/watch?v=n8kMghojZw4

Their original video :
https://www.youtube.com/watch?v=cCe5mg7X6zg

Thanks for this to Freddie555 from Hairsite

Quote:

---

Originally Posted by Sogeking

New videos from Replicel!

The Science behind Replicel :
https://www.youtube.com/watch?v=0tHDKT7uZp4

Replicel's Vision :
https://www.youtube.com/watch?v=n8kMghojZw4

Their original video :
https://www.youtube.com/watch?v=cCe5mg7X6zg

Thanks for this to Freddie555 from Hairsite

---

I wish they'd put some results out instead of pixar movies

or some kind of tangible date

anything but pixar clips and "experts"

Is it possible for replicel to have one successful trial and release this to the public.. Is long as it works and is safe i would have no problem spending my money on this.

Quote:

---

Originally Posted by Curlybill99

Is it possible for replicel to have one successful trial and release this to the public.. Is long as it works and is safe i would have no problem spending my money on this.

---

I don't think its possible... years of testing... even in lax countries in asia

Quote:

---

Originally Posted by Follicle Death Row

All the better for us then. Replicel is going to work I feel. As for when they'll perfect it and get it out to us is anyone's guess. I do have one problem with the procedure outlined: Why take a 4mm diameter punch? Could they not get the DSC from taking perhaps 4 1mm diameter punches. I'd rather have a few small dots than a little button scar. I'm getting way ahead of myself here. :D

---

I gotta say if this procedure works perfectly I am 100% cool with a 4mm punch. haha.

Awww the videos are saying 'private.' I saw this on my phone earlier as I was out walking around and I was going to watch it now but unfortunately I can't. :(

Its is interesting that Replicel notes only Phase 1 and 2 trials on their Website. Does this mean that if successful they could launch after Phase 2?

What i don't understand is why this has taken so long for it to get to the human trials stage this was found to be safe and effective years ago in mice, so why only now are human trials being done ? I'm not sure if it was an issue of funding, know how, or my worst fear just not worth the hassle for them if someone could explain i would be grateful.

If i could choose out of all the current trials going on right now which one i would want to succeed it would be this one as is seems very simple and non invasive, but of course efficacy hasn't even been shown in the trial data as of yet so i don't want to get too far ahead of myself. And i'm at the stage now where i just need to know if any of these potential treatments will work and we will know pretty soon within around 6 - 8 months, if it turns out that they don't work i'm just going to accept the fact that i need to buzz my head down and get on with life the best i can, but i will admit this is destroying my confidence and i have dealt with a lot of things in my life and got through them, this however i'm finding very very hard to deal with.

Quote:

---

Originally Posted by Losing_It

Its is interesting that Replicel notes only Phase 1 and 2 trials on their Website. Does this mean that if successful they could launch after Phase 2?

---

it means we still haven't seen one actual human result... just pixar movies of magic chemicals that float around under your scalp and find sleeping hair follicles

Quote:

---

Originally Posted by MrRyan

What i don't understand is why this has taken so long for it to get to the human trials stage this was found to be safe and effective years ago in mice, so why only now are human trials being done ? I'm not sure if it was an issue of funding, know how, or my worst fear just not worth the hassle for them if someone could explain i would be grateful.

If i could choose out of all the current trials going on right now which one i would want to succeed it would be this one as is seems very simple and non invasive, but of course efficacy hasn't even been shown in the trial data as of yet so i don't want to get too far ahead of myself. And i'm at the stage now where i just need to know if any of these potential treatments will work and we will know pretty soon within around 6 - 8 months, if it turns out that they don't work i'm just going to accept the fact that i need to buzz my head down and get on with life the best i can, but i will admit this is destroying my confidence and i have dealt with a lot of things in my life and got through them, this however i'm finding very very hard to deal with.

---

It's hard to know since they've released no statement regarding it but if I were to make a guess I'd say that their problem was not in finding out how to activate the hair follicles but in finding out how to reach the hair follicles to activate them, and being able to do so consistently and safely. It would make sense if the method of delivery was the problem as once they had solved that problem they could begin clinical trials to prove its potency and then move onto commercial release.

There are many reasons why I believe it has taken a long time to get to the clinical trial stage. One reason is that it takes time to raise the necessary funding. Another reason is that it is a lot more complicated than it appears to set up and execute a clinical trial. If you remember, Replicel was over a year late in beginning it's clinical trial after it had raised the necessary funding. If the trial is not set up correctly with the proper protcols and safeguards, the trial results may be useless in the eyes of the regulatory body that is charged with reviewing them. It seems that almost all of the players in this game have had delays in setting up & starting their clinical trials. But I believe the major reason that it has taken so long is that Replicel had to perfect a method of multiplying the cells taken from the punch biopsy into millions of cells for reinjection. If you have read any of the research in this area, one of the problems that had to be overcome was that after a certain number of passes, the cells start to loose their potency and take on an irregular shape. So I think the trick here is turning 1 DSC cell into many DSC cells such that they retain all of their characteristics and potency. Based on everything I have read, I believe Replicel has indentified the correct cell. It remains to be seen how effective their method of replicating these cells will be. One key point that I find highly suggestive of the confidence they have in their possibility of success is that they raised their funding and seemingly came from nowhere, after Aderans was already well into Phase II of their trials.

Please forgive my ignorance, but how exactly do the cells know what to do once they are injected is it simply that a cell just does what it does, or does it need other signals from the body to do their job like chemical signals or such like. If so how do they get around this do they use other factors in the injection, i'm sorry if this question sounds stupid, but i'm not very knowledgeable when it comes to human biology.

And one other question i can not for the life of me find one straight answer to is, do the hair follicles die or are they just dormant i'm hoping it's the latter as i'm sure many of you do, i ask this because i think this is massively important for things like Replicel and Histogen in regards to their efficacy.

Quote:

---

Originally Posted by MrRyan

Please forgive my ignorance, but how exactly do the cells know what to do once they are injected is it simply that a cell just does what it does, or does it need other signals from the body to do their job like chemical signals or such like. If so how do they get around this do they use other factors in the injection, i'm sorry if this question sounds stupid, but i'm not very knowledgeable when it comes to human biology.

And one other question i can not for the life of me find one straight answer to is, do the hair follicles die or are they just dormant i'm hoping it's the latter as i'm sure many of you do, i ask this because i think this is massively important for things like Replicel and Histogen in regards to their efficacy.

---

Q1 = Because cells are encoded with DNA -

Q2 = Yes, as opposed to scarring alopecia, male pattern hair loss does not destroy the stem cells needed to regenerate the hair follicle, hairs still exist but they are miniaturised even on NW 7 scalps -